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Neonatal Feeding Practices and SARS-CoV-2 Transmission in Neonates with Perinatal SARS-CoV-2 Exposure: A Systematic Review and Meta-Analysis.

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Title: Neonatal Feeding Practices and SARS-CoV-2 Transmission in Neonates with Perinatal SARS-CoV-2 Exposure: A Systematic Review and Meta-Analysis.
Authors: Babata, Kikelomo1 (AUTHOR) kikelomo.babata@utsouthwestern.edu, Sultana, Rehena2 (AUTHOR) rehena.sultana@duke-nus.edu.sg, Hascoët, Jean-Michel3 (AUTHOR) j.hascoet@chru-nancy.fr, Albert, Riya1 (AUTHOR) christina.chan@utsouthwestern.edu, Chan, Christina1 (AUTHOR) kelly.mazzarella@utsouthwestern.edu, Mazzarella, Kelly1 (AUTHOR) luc.brion@utsouthwestern.edu, Muhamed, Tanaz4 (AUTHOR) tanaz.k.muhamed.26@dartmouth.edu, Yeo, Kee Thai5 (AUTHOR) yeo.kee.thai@singhealth.com.sg, Kong, Juin Yee5 (AUTHOR) kong.juin.yee@singhealth.com.sg, Brion, Luc P.1 (AUTHOR)
Source: Journal of Clinical Medicine. Jan2025, Vol. 14 Issue 1, p280. 18p.
Subject Terms: *PREGNANT women, *RANDOM effects model, *NEONATAL infections, *BREAST milk, *VERTICAL transmission (Communicable diseases)
Abstract: Background: The risk of neonatal SARS-CoV-2 infection from the mother's own milk (MoM) in neonates who are exposed to maternal SARS-CoV-2 during the perinatal period remains unclear. We conducted a systematic review to assess the association between MoM feeding and neonatal SARS-CoV-2 infection in neonates who were born to SARS-CoV-2-positive pregnant persons. Methods: PubMed Central and Google Scholar were searched for studies published by 14 March 2024 that reported neonatal SARS-CoV-2 infection by feeding type. This search, including Scopus, was updated on 17 December 2024. The primary outcome was neonatal SARS-CoV-2 infection. The meta-analysis was conducted using a random effects model with two planned subgroup analyses: time of maternal PCR testing (at admission vs. previous 2 weeks) and dyad handling (isolation vs. some precautions vs. variable/NA). Results: The primary outcome was available in both arms of nine studies, including 5572 neonates who received MoM and 2215 who received no MoM. The GRADE rating was low quality, because the studies were observational (cohorts). The frequency of SARS-CoV-2 infection was similar in both arms (2.7% MoM vs. 2.2% no MoM), with a common risk ratio of 0.82 (95% confidence interval 0.44, 1.53, p = 0.54). No significant differences were observed in the subgroup analyses. Limitations include observational and incomplete data, other possible infection sources, small sample sizes for subgroup analyses, and neonates with more than one feeding type. Conclusions: Feeding MoM was not associated with an increased risk of neonatal SARS-CoV-2 infection among neonates who were born to mothers with perinatal infection. These data, along with reports showing a lack of active replicating SARS-CoV-2 virus in MoM, further support women with perinatal SARS-CoV-2 infection feeding MoM. Registration: PROSPERO ID CRD42021268576. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Neonatal Feeding Practices and SARS-CoV-2 Transmission in Neonates with Perinatal SARS-CoV-2 Exposure: A Systematic Review and Meta-Analysis.
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  Data: <searchLink fieldCode="AR" term="%22Babata%2C+Kikelomo%22">Babata, Kikelomo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kikelomo.babata@utsouthwestern.edu</i><br /><searchLink fieldCode="AR" term="%22Sultana%2C+Rehena%22">Sultana, Rehena</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> rehena.sultana@duke-nus.edu.sg</i><br /><searchLink fieldCode="AR" term="%22Hascoët%2C+Jean-Michel%22">Hascoët, Jean-Michel</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> j.hascoet@chru-nancy.fr</i><br /><searchLink fieldCode="AR" term="%22Albert%2C+Riya%22">Albert, Riya</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> christina.chan@utsouthwestern.edu</i><br /><searchLink fieldCode="AR" term="%22Chan%2C+Christina%22">Chan, Christina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kelly.mazzarella@utsouthwestern.edu</i><br /><searchLink fieldCode="AR" term="%22Mazzarella%2C+Kelly%22">Mazzarella, Kelly</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> luc.brion@utsouthwestern.edu</i><br /><searchLink fieldCode="AR" term="%22Muhamed%2C+Tanaz%22">Muhamed, Tanaz</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> tanaz.k.muhamed.26@dartmouth.edu</i><br /><searchLink fieldCode="AR" term="%22Yeo%2C+Kee+Thai%22">Yeo, Kee Thai</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> yeo.kee.thai@singhealth.com.sg</i><br /><searchLink fieldCode="AR" term="%22Kong%2C+Juin+Yee%22">Kong, Juin Yee</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> kong.juin.yee@singhealth.com.sg</i><br /><searchLink fieldCode="AR" term="%22Brion%2C+Luc+P%2E%22">Brion, Luc P.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+Medicine%22">Journal of Clinical Medicine</searchLink>. Jan2025, Vol. 14 Issue 1, p280. 18p.
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  Data: *<searchLink fieldCode="DE" term="%22PREGNANT+women%22">PREGNANT women</searchLink><br />*<searchLink fieldCode="DE" term="%22RANDOM+effects+model%22">RANDOM effects model</searchLink><br />*<searchLink fieldCode="DE" term="%22NEONATAL+infections%22">NEONATAL infections</searchLink><br />*<searchLink fieldCode="DE" term="%22BREAST+milk%22">BREAST milk</searchLink><br />*<searchLink fieldCode="DE" term="%22VERTICAL+transmission+%28Communicable+diseases%29%22">VERTICAL transmission (Communicable diseases)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The risk of neonatal SARS-CoV-2 infection from the mother's own milk (MoM) in neonates who are exposed to maternal SARS-CoV-2 during the perinatal period remains unclear. We conducted a systematic review to assess the association between MoM feeding and neonatal SARS-CoV-2 infection in neonates who were born to SARS-CoV-2-positive pregnant persons. Methods: PubMed Central and Google Scholar were searched for studies published by 14 March 2024 that reported neonatal SARS-CoV-2 infection by feeding type. This search, including Scopus, was updated on 17 December 2024. The primary outcome was neonatal SARS-CoV-2 infection. The meta-analysis was conducted using a random effects model with two planned subgroup analyses: time of maternal PCR testing (at admission vs. previous 2 weeks) and dyad handling (isolation vs. some precautions vs. variable/NA). Results: The primary outcome was available in both arms of nine studies, including 5572 neonates who received MoM and 2215 who received no MoM. The GRADE rating was low quality, because the studies were observational (cohorts). The frequency of SARS-CoV-2 infection was similar in both arms (2.7% MoM vs. 2.2% no MoM), with a common risk ratio of 0.82 (95% confidence interval 0.44, 1.53, p = 0.54). No significant differences were observed in the subgroup analyses. Limitations include observational and incomplete data, other possible infection sources, small sample sizes for subgroup analyses, and neonates with more than one feeding type. Conclusions: Feeding MoM was not associated with an increased risk of neonatal SARS-CoV-2 infection among neonates who were born to mothers with perinatal infection. These data, along with reports showing a lack of active replicating SARS-CoV-2 virus in MoM, further support women with perinatal SARS-CoV-2 infection feeding MoM. Registration: PROSPERO ID CRD42021268576. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/jcm14010280
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        Text: English
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        Type: general
      – SubjectFull: RANDOM effects model
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      – SubjectFull: BREAST milk
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      – SubjectFull: VERTICAL transmission (Communicable diseases)
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      – TitleFull: Neonatal Feeding Practices and SARS-CoV-2 Transmission in Neonates with Perinatal SARS-CoV-2 Exposure: A Systematic Review and Meta-Analysis.
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              Text: Jan2025
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