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Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES).

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Title: Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES).
Authors: Benito-Rodríguez, Carla María1 (AUTHOR) cbenirod@myuax.com, Bermejo-Pareja, Félix2 (AUTHOR) fbermejop@h12o.es, Berbel, Angel1,3 (AUTHOR) angel.berbel@salud.madrid.org, Lapeña-Motilva, José2,4 (AUTHOR) lapena@salud.madrid.org, Benito-León, Julián2,4,5,6 (AUTHOR) julian.benito@salud.madrid.org
Source: Journal of Clinical Medicine. Jan2025, Vol. 14 Issue 2, p498. 18p.
Subject Terms: *PROPORTIONAL hazards models, *PARKINSON'S disease, *CEREBROVASCULAR disease, *OLDER people, *CAUSES of death, CAUSE of death statistics
Abstract: Background: Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a comprehensive 23-year mortality analysis in a Spanish population. Methods: In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994–1995) and follow-up (1997–1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables. Results: Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31–2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24–3.89). Early-onset PD (<65 years) showed heightened mortality risk (HR = 2.11; 95% CI = 1.22–3.64). Cardiovascular and cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD patients compared to the reference group (14.7% vs. 0.4%, p < 0.001). Conclusions: PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings underscore the importance of a multidisciplinary approach to PD care, targeting both motor and non-motor symptoms to enhance long-term outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Twenty-Three-Year Mortality in Parkinson&#39;s Disease: A Population-Based Prospective Study (NEDICES).
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Clinical+Medicine%22&quot;&gt;Journal of Clinical Medicine&lt;/searchLink&gt;. Jan2025, Vol. 14 Issue 2, p498. 18p.
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  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PROPORTIONAL+hazards+models%22&quot;&gt;PROPORTIONAL hazards models&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PARKINSON&#39;S+disease%22&quot;&gt;PARKINSON&#39;S disease&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CEREBROVASCULAR+disease%22&quot;&gt;CEREBROVASCULAR disease&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22OLDER+people%22&quot;&gt;OLDER people&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CAUSES+of+death%22&quot;&gt;CAUSES of death&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CAUSE+of+death+statistics%22&quot;&gt;CAUSE of death statistics&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Parkinson&#39;s disease (PD) is one of the most prevalent neurodegenerative disorders among older adults, yet its long-term impact on mortality within population-based cohorts remains insufficiently characterized. This study leverages data from the Neurological Disorders in Central Spain (NEDICES) cohort to provide a comprehensive 23-year mortality analysis in a Spanish population. Methods: In this prospective cohort study, 5278 individuals aged 65 years and older were evaluated across two waves: baseline (1994–1995) and follow-up (1997–1998). At baseline, 81 prevalent PD cases were identified, while 30 incident cases, likely in the premotor phase at baseline, were detected during follow-up. Mortality was tracked over 23 years, and Cox proportional hazard models were employed to estimate hazard ratios (HRs) for mortality, adjusting for relevant demographic and clinical variables. Results: Fifty-three individuals from the cohort in the reference group (without PD) were excluded due to unreliable mortality data. Among 111 PD cases, 109 (98.2%) died during follow-up compared to 4440 (86.8%) of 5114 without the disease. PD was associated with a significantly increased mortality risk (adjusted HR = 1.62; 95% confidence interval [CI] = 1.31–2.01). Patients with both PD and dementia had an even higher risk (HR = 2.19; 95% CI = 1.24–3.89). Early-onset PD (&lt;65 years) showed heightened mortality risk (HR = 2.11; 95% CI = 1.22–3.64). Cardiovascular and cerebrovascular diseases were the leading causes of death in both PD and non-PD participants. PD was significantly more often listed as the primary cause of death in PD patients compared to the reference group (14.7% vs. 0.4%, p &lt; 0.001). Conclusions: PD significantly increases mortality risk over 23 years, particularly among those with early onset and dementia. These findings underscore the importance of a multidisciplinary approach to PD care, targeting both motor and non-motor symptoms to enhance long-term outcomes. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3390/jcm14020498
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 498
    Subjects:
      – SubjectFull: PROPORTIONAL hazards models
        Type: general
      – SubjectFull: PARKINSON'S disease
        Type: general
      – SubjectFull: CEREBROVASCULAR disease
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      – SubjectFull: OLDER people
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      – SubjectFull: CAUSES of death
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      – SubjectFull: CAUSE of death statistics
        Type: general
    Titles:
      – TitleFull: Twenty-Three-Year Mortality in Parkinson's Disease: A Population-Based Prospective Study (NEDICES).
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            NameFull: Benito-Rodríguez, Carla María
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              Text: Jan2025
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