Bibliographic Details
| Title: |
S6K2 in Focus: Signaling Pathways, Post-Translational Modifications, and Computational Analysis. |
| Authors: |
Khalil, Mahmoud I.1,2 (AUTHOR) m.khalil@bau.edu.lb, Helal, Mohamed3,4 (AUTHOR) mhelal@biology.sdu.dk, El-Sayed, Ahmed F.5,6 (AUTHOR) ahmedfikry.nrc@gmail.com, El Hajj, Rana1 (AUTHOR), Holail, Jasmine7,8 (AUTHOR) rb22182@bristol.ac.uk, Houssein, Marwa9 (AUTHOR) housseinmarwa@gmail.com, Waraky, Ahmed10,11,12 (AUTHOR) ahmed.waraky@gu.se, Pardo, Olivier E.13 (AUTHOR) m.khalil@bau.edu.lb |
| Source: |
International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 1, p176. 31p. |
| Subject Terms: |
*POST-translational modification, *POLLUTANTS, *MOLECULAR docking, *BINDING sites, *MOLECULAR dynamics |
| Abstract: |
S6 Kinase 2 (S6K2) is a key regulator of cellular signaling and is crucial for cell growth, proliferation, and survival. This review is divided into two parts: the first focuses on the complex network of upstream effectors, downstream modulators, and post-translational modifications (PTMs) that regulate S6K2 activity. We emphasize the dynamic nature of S6K2 regulation, highlighting its critical role in cellular homeostasis and its potential as a therapeutic target in diseases like cancer. The second part utilizes in silico analyses, employing computational tools to model S6K2's three-dimensional structure and predict its interaction networks. Molecular dynamics simulations and docking studies reveal potential binding sites and interactions with novel known inhibitors. We also examine the effects of environmental contaminants that potentially disrupt S6K2 function and provide insights into the role of external factors that could impact its regulatory mechanisms. These computational findings provide a deeper understanding of the conformational dynamics of S6K2 and its interactions with its inhibitors. Together, this integrated biochemical and computational approach enhances our understanding of S6K2 regulation and identifies potential new therapeutic strategies targeting S6K2 in the oncology setting. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
