Bibliographic Details
| Title: |
Clinical efficacy of various resuscitation fluids in the management of sepsis in postoperative surgical and trauma patients: a systematic review and meta-analysis. |
| Authors: |
Yongjie Wang1, Kewu Chen2, Xiaolu Li3, Jianing Guan4 guanjn9249@sina.com |
| Source: |
Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i Inne Techniki Mało Inwazyjne. 2024, Vol. 19 Issue 3, p275-288. 14p. |
| Subject Terms: |
*HYDROXYETHYL starch, *TREATMENT effectiveness, *DEGREES of freedom, *MORTALITY, *DATABASES |
| Abstract: |
INTRODUCTION Fluid resuscitation is the primary sepsis management strategy aimed at reducing mortality and achieving better treatment outcomes in critically hypotensive patients. Still, there are significant ambiguities regarding the most suitable fluid type that would ensure optimization of patient outcomes. AIM The aim of this systematic review and meta-analysis was to assess the clinical effectiveness of different resuscitation fluids for sepsis management in critically hypotensive patients. MATERIALS AND METHODS A systematic search of 4 electronic databases (PubMed, EMBASE, Scopus, and Cochrane Library) was conducted to identify relevant papers published in peer-reviewed journals since database inception until June 30, 2024. Odds ratios (ORs) with 95% CIs were calculated to evaluate the impact of individual resuscitation fluids on improvements in hemodynamic parameters and all-cause mortality. Heterogeneity was assessed using the Cochran Q, I2 statistic, and the appropriate P value. RESULTS Our meta-analysis included 18 randomized controlled trials comparing the efficacy of different resuscitation fluids for sepsis management in 14 469 critically hypotensive patients. We found that Ringer's lactate solution was more effective than saline in reducing mortality (OR, 0.53; 95% CI, 0.41-0.7; χ²= 3.47; degree of freedom [df] = 6; Z = 4.6; I² = 0%; P <0.001) and improving hemodynamic parameters (OR, 2.64; 95% CI, 2.45-2.86; χ² = 48.36; df = 6; Z = 24.84; I² = 18%; P <0.001). However, saline was superior to albumin and hydroxyethyl starch in reaching these end points. CONCLUSION We showed that in critically hypotensive septic patients, Ringer's lactate solution reduces all-cause mortality and improves hemodynamic parameters more effectively than saline, hydroxyethyl starch, and albumin solutions. [ABSTRACT FROM AUTHOR] |
|
Copyright of Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i Inne Techniki Mało Inwazyjne is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
