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Seizures elicited by transcorneal 6 Hz stimulation in developing rats.

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Title: Seizures elicited by transcorneal 6 Hz stimulation in developing rats.
Authors: Mareš, Pavel1 (AUTHOR) maresp@biomed.cas.cz, Metcalf, Cameron S.2 (AUTHOR), Baloun, Jiří3 (AUTHOR), Kubová, Hana1 (AUTHOR)
Source: PLoS ONE. 1/3/2025, Vol. 20 Issue 1, p1-12. 12p.
Subject Terms: *AGE groups, *TEMPORAL lobe, *SEIZURES (Medicine), *ADULTS, *RATS
Abstract: Seizures elicited by corneal 6-Hz stimulation are widely acknowledged as a model of temporal lobe seizures. Despite the intensive research in rodents, no studies hint at this model in developing animals. We focused on seven age groups of both male and female rats. Biphasic pulses with 0.3 ms duration and current intensities from 20 to 80 mA were applied transcorneally for 3 s to calculate threshold intensities for individual age groups. Threshold stimulation intensity necessary for elicitation of clonic seizures was highly age- and sex-dependent. The highest threshold was observed in the youngest (15-day-old) group then it decreased to the age of 25 days and increased again up to adulthood. The threshold current tended to be lower in females of all age groups. The incidence of convulsive seizures increased with stimulation intensity up to postnatal day 25 in either sex. In rats of 31 days old and older convulsions occurred irregularly regardless of the stimulation current and sex. For subsequent analysis, the animals were categorized into two groups: juveniles, aged 15 to 25 days, and adolescents/adults, aged 31 days and older. Our statistical analyses revealed an increased risk of convulsions after the stimulation with higher intensities in juvenile but not adolescent/adult rats. Females tended to be more sensitive to the stimulation with lower currents than males. Seizure severity was higher in females 18- to 25-day old compared to males of the same age and the seizure duration increased with stimulation intensities in juvenile but not adolescent/adult animals. The data extend the use of the rat 6 Hz model to immature animals and may be useful as a model of pediatric temporal lobe seizures. [ABSTRACT FROM AUTHOR]
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Seizures elicited by transcorneal 6 Hz stimulation in developing rats.
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  Data: <searchLink fieldCode="AR" term="%22Mareš%2C+Pavel%22">Mareš, Pavel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> maresp@biomed.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Metcalf%2C+Cameron+S%2E%22">Metcalf, Cameron S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baloun%2C+Jiří%22">Baloun, Jiří</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kubová%2C+Hana%22">Kubová, Hana</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22PLoS+ONE%22">PLoS ONE</searchLink>. 1/3/2025, Vol. 20 Issue 1, p1-12. 12p.
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  Data: *<searchLink fieldCode="DE" term="%22AGE+groups%22">AGE groups</searchLink><br />*<searchLink fieldCode="DE" term="%22TEMPORAL+lobe%22">TEMPORAL lobe</searchLink><br />*<searchLink fieldCode="DE" term="%22SEIZURES+%28Medicine%29%22">SEIZURES (Medicine)</searchLink><br />*<searchLink fieldCode="DE" term="%22ADULTS%22">ADULTS</searchLink><br />*<searchLink fieldCode="DE" term="%22RATS%22">RATS</searchLink>
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  Label: Abstract
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  Data: Seizures elicited by corneal 6-Hz stimulation are widely acknowledged as a model of temporal lobe seizures. Despite the intensive research in rodents, no studies hint at this model in developing animals. We focused on seven age groups of both male and female rats. Biphasic pulses with 0.3 ms duration and current intensities from 20 to 80 mA were applied transcorneally for 3 s to calculate threshold intensities for individual age groups. Threshold stimulation intensity necessary for elicitation of clonic seizures was highly age- and sex-dependent. The highest threshold was observed in the youngest (15-day-old) group then it decreased to the age of 25 days and increased again up to adulthood. The threshold current tended to be lower in females of all age groups. The incidence of convulsive seizures increased with stimulation intensity up to postnatal day 25 in either sex. In rats of 31 days old and older convulsions occurred irregularly regardless of the stimulation current and sex. For subsequent analysis, the animals were categorized into two groups: juveniles, aged 15 to 25 days, and adolescents/adults, aged 31 days and older. Our statistical analyses revealed an increased risk of convulsions after the stimulation with higher intensities in juvenile but not adolescent/adult rats. Females tended to be more sensitive to the stimulation with lower currents than males. Seizure severity was higher in females 18- to 25-day old compared to males of the same age and the seizure duration increased with stimulation intensities in juvenile but not adolescent/adult animals. The data extend the use of the rat 6 Hz model to immature animals and may be useful as a model of pediatric temporal lobe seizures. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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              Text: 1/3/2025
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