Three decades of research in lymphatic filariasis-lessons learned.
| Title: | Three decades of research in lymphatic filariasis-lessons learned. |
|---|---|
| Authors: | Krishnasastry, Suma1 (AUTHOR) sumatk@gmail.com |
| Source: | Tropical Parasitology. Jul-Dec2024, Vol. 14 Issue 2, p65-70. 6p. |
| Subject Terms: | *FILARIASIS, *DRUG efficacy, *SOCIOECONOMIC factors, *DISEASE management, *INFECTIOUS disease transmission |
| Abstract: | Lymphatic filariasis (LF), one of the 21 Neglected Tropical Diseases (NTD) which is the second leading cause for disability globally. Wuchereria Bancrofti , Brugia malayi and Brugia timori are the parasites causing this infection. World Health Assembly in 1997 declared LF to be eliminated and the Global Program to eliminate LF (GPELF) was launched by WHO in 2000 with the two strategies viz, 1) stop transmission of infection through Mass Drug Administration (MDA) and 2) to alleviate the suffering of the people affected with the disease through Morbidity Management and Disability Prevention (MMDP. The 'Filariasis research unit' recommended by WHO TDR and ICMR was established in Alappuzha, Kerala in 1989 for research studies related to LF. Over the last three decades 23 studies have been completed, which included different trials to find out the dose, effectiveness and safety of the various drugs used in preventive chemotherapy as single drug or combinations, for treatment of microfilaraemia,, various studies related to morbidity management in filarial disease, socio-economic aspects of filarial disability, Pharmacokinetic study of antifilarial drugs, Study on lymphatic filariasis in children, Studies on dignostics of LF, efficacy of drugs in management of lymphedema etc. In this article an attempt is made to explain the lessons learned from these studies and its importance in development of policy decision making for GPELF. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Three decades of research in lymphatic filariasis-lessons learned. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Krishnasastry%2C+Suma%22">Krishnasastry, Suma</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sumatk@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Tropical+Parasitology%22">Tropical Parasitology</searchLink>. Jul-Dec2024, Vol. 14 Issue 2, p65-70. 6p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22FILARIASIS%22">FILARIASIS</searchLink><br />*<searchLink fieldCode="DE" term="%22DRUG+efficacy%22">DRUG efficacy</searchLink><br />*<searchLink fieldCode="DE" term="%22SOCIOECONOMIC+factors%22">SOCIOECONOMIC factors</searchLink><br />*<searchLink fieldCode="DE" term="%22DISEASE+management%22">DISEASE management</searchLink><br />*<searchLink fieldCode="DE" term="%22INFECTIOUS+disease+transmission%22">INFECTIOUS disease transmission</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Lymphatic filariasis (LF), one of the 21 Neglected Tropical Diseases (NTD) which is the second leading cause for disability globally. Wuchereria Bancrofti , Brugia malayi and Brugia timori are the parasites causing this infection. World Health Assembly in 1997 declared LF to be eliminated and the Global Program to eliminate LF (GPELF) was launched by WHO in 2000 with the two strategies viz, 1) stop transmission of infection through Mass Drug Administration (MDA) and 2) to alleviate the suffering of the people affected with the disease through Morbidity Management and Disability Prevention (MMDP. The 'Filariasis research unit' recommended by WHO TDR and ICMR was established in Alappuzha, Kerala in 1989 for research studies related to LF. Over the last three decades 23 studies have been completed, which included different trials to find out the dose, effectiveness and safety of the various drugs used in preventive chemotherapy as single drug or combinations, for treatment of microfilaraemia,, various studies related to morbidity management in filarial disease, socio-economic aspects of filarial disability, Pharmacokinetic study of antifilarial drugs, Study on lymphatic filariasis in children, Studies on dignostics of LF, efficacy of drugs in management of lymphedema etc. In this article an attempt is made to explain the lessons learned from these studies and its importance in development of policy decision making for GPELF. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Tropical Parasitology is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.4103/tp.tp_22_24 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 65 Subjects: – SubjectFull: FILARIASIS Type: general – SubjectFull: DRUG efficacy Type: general – SubjectFull: SOCIOECONOMIC factors Type: general – SubjectFull: DISEASE management Type: general – SubjectFull: INFECTIOUS disease transmission Type: general Titles: – TitleFull: Three decades of research in lymphatic filariasis-lessons learned. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Krishnasastry, Suma IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul-Dec2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 22295070 Numbering: – Type: volume Value: 14 – Type: issue Value: 2 Titles: – TitleFull: Tropical Parasitology Type: main |
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