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CXCR4 promotes migration, invasion, and epithelial–mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway.

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Title: CXCR4 promotes migration, invasion, and epithelial–mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway.
Authors: Hu, Yajie1 (AUTHOR), Xu, Zhipeng1,2 (AUTHOR), Zhou, Dongsheng3 (AUTHOR), Hou, Haitao4 (AUTHOR), Liu, Bin4 (AUTHOR), Long, Houlong4 (AUTHOR), Hu, Wenxin2 (AUTHOR), Tang, Yuanqi5 (AUTHOR), Wang, Jianning2 (AUTHOR), Wei, Dan1,5 (AUTHOR) 77weidan@163.com, Zhao, Quanlin1 (AUTHOR) 18516188617@163.com
Source: Journal of Cancer Research & Therapeutics. Aug2024, Vol. 20 Issue 4, p1241-1250. 10p.
Subject Terms: *CXCR4 receptors, *CYTOSKELETON, *CELL migration, *CELL motility, *LYMPHATIC metastasis
Abstract: Aims: Papillary thyroid cancer (PTC) is a serious threat to human health worldwide, while metastasis in the early phase limits therapeutic success and leads to poor survival outcomes. The CXC chemokine receptor type 4 (CXCR4) plays an important role in many cellular movements such as transcriptional modulation, cell skeleton rearrangement, and cell migration, and the change in CXCR4 levels are crucial in various diseases including cancer. In this study, we explored the role of CXCR4 in the migration and invasion of PTC and investigated the potential mechanisms underlying its effects. Subjects and Methods: We analyzed the expression levels of CXCR4 in PTC tissues and cell lines. Would healing migration, Transwell invasion assay in vitro , and tail-vein lung metastasis assay In vivo were performed to evaluated the migration and invasion abilities of PTC cells with stable CXCR4 knockdown or overexpression. Signal transducers and activators of transcription (STAT3) signaling pathway-related protein expressions were examined by Western blotting assays. Results: The results showed that CXCR4 was highly expressed in PTC cell lines and PTC tissues. CXCR4 knockdown in PTC cells dampened the migration, invasion, and epithelial–mesenchymal transition (EMT), whereas CXCR4 overexpression enhanced these properties. In vivo , we also found that CXCR4 promoted the metastasis of PTC. Mechanistic studies showed that CXCR4 played these vital roles through the STAT3 signaling pathway. Furthermore, PTC patients with high CXCR4 or p-STAT3 expression correlated with aggressive clinical characteristics such as extrathyroidal extension (ETE), and lymph node metastasis (LNM). Conclusions: We provided evidence that CXCR4 might activate the STAT3 signaling pathway and further promote PTC development. Thus, CXCR4 might be a novel therapeutic target for PTC. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Cancer Research & Therapeutics is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: CXCR4 promotes migration, invasion, and epithelial–mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway.
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  Data: <searchLink fieldCode="AR" term="%22Hu%2C+Yajie%22">Hu, Yajie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Zhipeng%22">Xu, Zhipeng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Dongsheng%22">Zhou, Dongsheng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hou%2C+Haitao%22">Hou, Haitao</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Bin%22">Liu, Bin</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Long%2C+Houlong%22">Long, Houlong</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Wenxin%22">Hu, Wenxin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Yuanqi%22">Tang, Yuanqi</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jianning%22">Wang, Jianning</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Dan%22">Wei, Dan</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<i> 77weidan@163.com</i><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Quanlin%22">Zhao, Quanlin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> 18516188617@163.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Cancer+Research+%26+Therapeutics%22">Journal of Cancer Research & Therapeutics</searchLink>. Aug2024, Vol. 20 Issue 4, p1241-1250. 10p.
– Name: Subject
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  Data: *<searchLink fieldCode="DE" term="%22CXCR4+receptors%22">CXCR4 receptors</searchLink><br />*<searchLink fieldCode="DE" term="%22CYTOSKELETON%22">CYTOSKELETON</searchLink><br />*<searchLink fieldCode="DE" term="%22CELL+migration%22">CELL migration</searchLink><br />*<searchLink fieldCode="DE" term="%22CELL+motility%22">CELL motility</searchLink><br />*<searchLink fieldCode="DE" term="%22LYMPHATIC+metastasis%22">LYMPHATIC metastasis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aims: Papillary thyroid cancer (PTC) is a serious threat to human health worldwide, while metastasis in the early phase limits therapeutic success and leads to poor survival outcomes. The CXC chemokine receptor type 4 (CXCR4) plays an important role in many cellular movements such as transcriptional modulation, cell skeleton rearrangement, and cell migration, and the change in CXCR4 levels are crucial in various diseases including cancer. In this study, we explored the role of CXCR4 in the migration and invasion of PTC and investigated the potential mechanisms underlying its effects. Subjects and Methods: We analyzed the expression levels of CXCR4 in PTC tissues and cell lines. Would healing migration, Transwell invasion assay in vitro , and tail-vein lung metastasis assay In vivo were performed to evaluated the migration and invasion abilities of PTC cells with stable CXCR4 knockdown or overexpression. Signal transducers and activators of transcription (STAT3) signaling pathway-related protein expressions were examined by Western blotting assays. Results: The results showed that CXCR4 was highly expressed in PTC cell lines and PTC tissues. CXCR4 knockdown in PTC cells dampened the migration, invasion, and epithelial–mesenchymal transition (EMT), whereas CXCR4 overexpression enhanced these properties. In vivo , we also found that CXCR4 promoted the metastasis of PTC. Mechanistic studies showed that CXCR4 played these vital roles through the STAT3 signaling pathway. Furthermore, PTC patients with high CXCR4 or p-STAT3 expression correlated with aggressive clinical characteristics such as extrathyroidal extension (ETE), and lymph node metastasis (LNM). Conclusions: We provided evidence that CXCR4 might activate the STAT3 signaling pathway and further promote PTC development. Thus, CXCR4 might be a novel therapeutic target for PTC. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Cancer Research & Therapeutics is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.4103/jcrt.jcrt_2395_22
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 1241
    Subjects:
      – SubjectFull: CXCR4 receptors
        Type: general
      – SubjectFull: CYTOSKELETON
        Type: general
      – SubjectFull: CELL migration
        Type: general
      – SubjectFull: CELL motility
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      – SubjectFull: LYMPHATIC metastasis
        Type: general
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      – TitleFull: CXCR4 promotes migration, invasion, and epithelial–mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway.
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            – D: 01
              M: 08
              Text: Aug2024
              Type: published
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