Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells.
| Title: | Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells. |
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| Authors: | Siles-Sánchez, María de las Nieves1 (AUTHOR), Fernández-Jalao, Irene1 (AUTHOR), Jaime De Pablo, Laura1 (AUTHOR), Santoyo, Susana1 (AUTHOR) susana.santoyo@uam.es |
| Source: | Drug Delivery. Dec2024, Vol. 31 Issue 1, p1-11. 11p. |
| Subject Terms: | *COMMON yarrow, *PHENOLS, *MOLECULAR weights, *COLORECTAL cancer, *YARROW, *CHLOROGENIC acid, *SPRAY drying, *GELATION |
| Abstract: | In this study, chitosan low molecular weight (LCH) and chitosan medium molecular weight (MCH) were employed to encapsulate a yarrow extract rich in chlorogenic acid and dicaffeoylquinic acids (DCQAs) that showed antiproliferative activity against colon adenocarcinoma cells. The design of CH micro/nanoparticles to increase the extract colon delivery was carried out by using two different techniques: ionic gelation and spray drying. Ionic gelation nanoparticles obtained were smaller and presented higher yields values than spray-drying microparticles, but spray-drying microparticles showed the best performance in terms of encapsulation efficiency (EE) (> 94%), also allowing the inclusion of a higher quantity of extract. Spray-drying microparticles designed using LCH with an LCH:extract ratio of 6:1 (1.25 mg/mL) showed a mean diameter of 1.31 ± 0.21 µm and EE values > 93%, for all phenolic compounds studied. The release profile of phenolic compounds included in this formulation, at gastrointestinal pHs (2 and 7.4), showed for most of them a small initial release, followed by an increase at 1 h, with a constant release up to 3 h. Chlorogenic acid presented the higher release values at 3 h (56.91% at pH 2; 44.45% at pH 7.4). DCQAs release at 3 h ranged between 9.01- 40.73%, being higher for 1,5- and 3,4-DCQAs. After gastrointestinal digestion, 67.65% of chlorogenic and most DCQAs remained encapsulated. Therefore, spray-drying microparticles can be proposed as a promising vehicle to increase the colon delivery of yarrow phenolics compounds (mainly chlorogenic acid and DCQAs) previously described as potential agents against colorectal cancer. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Siles-Sánchez%2C+María+de+las+Nieves%22">Siles-Sánchez, María de las Nieves</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fernández-Jalao%2C+Irene%22">Fernández-Jalao, Irene</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jaime+De+Pablo%2C+Laura%22">Jaime De Pablo, Laura</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Santoyo%2C+Susana%22">Santoyo, Susana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> susana.santoyo@uam.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Drug+Delivery%22">Drug Delivery</searchLink>. Dec2024, Vol. 31 Issue 1, p1-11. 11p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22COMMON+yarrow%22">COMMON yarrow</searchLink><br />*<searchLink fieldCode="DE" term="%22PHENOLS%22">PHENOLS</searchLink><br />*<searchLink fieldCode="DE" term="%22MOLECULAR+weights%22">MOLECULAR weights</searchLink><br />*<searchLink fieldCode="DE" term="%22COLORECTAL+cancer%22">COLORECTAL cancer</searchLink><br />*<searchLink fieldCode="DE" term="%22YARROW%22">YARROW</searchLink><br />*<searchLink fieldCode="DE" term="%22CHLOROGENIC+acid%22">CHLOROGENIC acid</searchLink><br />*<searchLink fieldCode="DE" term="%22SPRAY+drying%22">SPRAY drying</searchLink><br />*<searchLink fieldCode="DE" term="%22GELATION%22">GELATION</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In this study, chitosan low molecular weight (LCH) and chitosan medium molecular weight (MCH) were employed to encapsulate a yarrow extract rich in chlorogenic acid and dicaffeoylquinic acids (DCQAs) that showed antiproliferative activity against colon adenocarcinoma cells. The design of CH micro/nanoparticles to increase the extract colon delivery was carried out by using two different techniques: ionic gelation and spray drying. Ionic gelation nanoparticles obtained were smaller and presented higher yields values than spray-drying microparticles, but spray-drying microparticles showed the best performance in terms of encapsulation efficiency (EE) (> 94%), also allowing the inclusion of a higher quantity of extract. Spray-drying microparticles designed using LCH with an LCH:extract ratio of 6:1 (1.25 mg/mL) showed a mean diameter of 1.31 ± 0.21 µm and EE values > 93%, for all phenolic compounds studied. The release profile of phenolic compounds included in this formulation, at gastrointestinal pHs (2 and 7.4), showed for most of them a small initial release, followed by an increase at 1 h, with a constant release up to 3 h. Chlorogenic acid presented the higher release values at 3 h (56.91% at pH 2; 44.45% at pH 7.4). DCQAs release at 3 h ranged between 9.01- 40.73%, being higher for 1,5- and 3,4-DCQAs. After gastrointestinal digestion, 67.65% of chlorogenic and most DCQAs remained encapsulated. Therefore, spray-drying microparticles can be proposed as a promising vehicle to increase the colon delivery of yarrow phenolics compounds (mainly chlorogenic acid and DCQAs) previously described as potential agents against colorectal cancer. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Drug Delivery is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/10717544.2024.2372285 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: COMMON yarrow Type: general – SubjectFull: PHENOLS Type: general – SubjectFull: MOLECULAR weights Type: general – SubjectFull: COLORECTAL cancer Type: general – SubjectFull: YARROW Type: general – SubjectFull: CHLOROGENIC acid Type: general – SubjectFull: SPRAY drying Type: general – SubjectFull: GELATION Type: general Titles: – TitleFull: Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Siles-Sánchez, María de las Nieves – PersonEntity: Name: NameFull: Fernández-Jalao, Irene – PersonEntity: Name: NameFull: Jaime De Pablo, Laura – PersonEntity: Name: NameFull: Santoyo, Susana IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 10717544 Numbering: – Type: volume Value: 31 – Type: issue Value: 1 Titles: – TitleFull: Drug Delivery Type: main |
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