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Venetoclax-based induction therapy for primary plasma cell leukemia with high BCL-2 expression.

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Title: Venetoclax-based induction therapy for primary plasma cell leukemia with high BCL-2 expression.
Authors: Charalampous, Charalampos1 (AUTHOR), Doucette, Kimberley1,2 (AUTHOR), Chappell, Aimee1,2 (AUTHOR), Vesole, David H.1,2,3 (AUTHOR) david.vesole@hmhn.org
Source: Leukemia & Lymphoma. Dec2024, Vol. 65 Issue 12, p1901-1904. 4p.
Subject Terms: *PLASMA cell leukemia, *PLASMA cell diseases, *IMMUNOGLOBULIN light chains, *POSITRON emission tomography computed tomography, *PLASMA cells
Abstract: The article discusses the use of venetoclax, a BCL-2 inhibitor, in the treatment of primary plasma cell leukemia (PCL) with high BCL-2 expression. PCL is a rare and aggressive form of plasma cell dyscrasias with a poor prognosis. The case study presented in the article shows a patient with primary PCL who achieved a durable complete response to a venetoclax-based induction regimen without autologous stem cell transplant. The study suggests that venetoclax may be an effective and tolerable treatment option for PCL patients, especially those with high BCL-2 expression. Further research is needed to validate these findings and explore new treatment avenues for PCL patients. [Extracted from the article]
Copyright of Leukemia & Lymphoma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Venetoclax-based induction therapy for primary plasma cell leukemia with high BCL-2 expression.
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  Data: <searchLink fieldCode="AR" term="%22Charalampous%2C+Charalampos%22">Charalampous, Charalampos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doucette%2C+Kimberley%22">Doucette, Kimberley</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chappell%2C+Aimee%22">Chappell, Aimee</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vesole%2C+David+H%2E%22">Vesole, David H.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> david.vesole@hmhn.org</i>
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  Data: <searchLink fieldCode="JN" term="%22Leukemia+%26+Lymphoma%22">Leukemia & Lymphoma</searchLink>. Dec2024, Vol. 65 Issue 12, p1901-1904. 4p.
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  Data: *<searchLink fieldCode="DE" term="%22PLASMA+cell+leukemia%22">PLASMA cell leukemia</searchLink><br />*<searchLink fieldCode="DE" term="%22PLASMA+cell+diseases%22">PLASMA cell diseases</searchLink><br />*<searchLink fieldCode="DE" term="%22IMMUNOGLOBULIN+light+chains%22">IMMUNOGLOBULIN light chains</searchLink><br />*<searchLink fieldCode="DE" term="%22POSITRON+emission+tomography+computed+tomography%22">POSITRON emission tomography computed tomography</searchLink><br />*<searchLink fieldCode="DE" term="%22PLASMA+cells%22">PLASMA cells</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article discusses the use of venetoclax, a BCL-2 inhibitor, in the treatment of primary plasma cell leukemia (PCL) with high BCL-2 expression. PCL is a rare and aggressive form of plasma cell dyscrasias with a poor prognosis. The case study presented in the article shows a patient with primary PCL who achieved a durable complete response to a venetoclax-based induction regimen without autologous stem cell transplant. The study suggests that venetoclax may be an effective and tolerable treatment option for PCL patients, especially those with high BCL-2 expression. Further research is needed to validate these findings and explore new treatment avenues for PCL patients. [Extracted from the article]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Leukemia & Lymphoma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/10428194.2024.2381647
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 1901
    Subjects:
      – SubjectFull: PLASMA cell leukemia
        Type: general
      – SubjectFull: PLASMA cell diseases
        Type: general
      – SubjectFull: IMMUNOGLOBULIN light chains
        Type: general
      – SubjectFull: POSITRON emission tomography computed tomography
        Type: general
      – SubjectFull: PLASMA cells
        Type: general
    Titles:
      – TitleFull: Venetoclax-based induction therapy for primary plasma cell leukemia with high BCL-2 expression.
        Type: main
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            NameFull: Charalampous, Charalampos
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            NameFull: Doucette, Kimberley
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            NameFull: Chappell, Aimee
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            NameFull: Vesole, David H.
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          Dates:
            – D: 01
              M: 12
              Text: Dec2024
              Type: published
              Y: 2024
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              Value: 65
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              Value: 12
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            – TitleFull: Leukemia & Lymphoma
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