Academic Journal
View in EDS
HTML Full Text

The Influence of Physical Training on Breast Cancer: The Role of Exercise-Induced Myokines in Regulating Breast Cancer Cell Growth and Survival.

Bibliographic Details
Title: The Influence of Physical Training on Breast Cancer: The Role of Exercise-Induced Myokines in Regulating Breast Cancer Cell Growth and Survival.
Authors: Natarajan, Anirudh1,2 (AUTHOR) anirudh.natarajan@uk-erlangen.de, Pradhan, Rashmita1,2 (AUTHOR) rashmita.pradhan@uk-erlangen.de, Dieterich, Walburga1,2 (AUTHOR) walburga.dieterich@uk-erlangen.de, Schwappacher, Raphaela1,2 (AUTHOR) dejan.reljic@uk-erlangen.de, Reljic, Dejan1,2 (AUTHOR) hans.herrmann@uk-erlangen.de, Herrmann, Hans J.1,2 (AUTHOR) markus.neurath@uk-erlangen.de, Neurath, Markus F.1 (AUTHOR), Hack, Carolin C.3 (AUTHOR) carolin.hack@uk-erlangen.de, Beckmann, Matthias W.3 (AUTHOR) fk-direktion@uk-erlangen.de, Zopf, Yurdagül1,2 (AUTHOR) yurdaguel.zopf@uk-erlangen.de
Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11379. 18p.
Subject Terms: *EXERCISE physiology, *STRENGTH training, *RESISTANCE training, *CANCER cell growth, *MYOKINES
Abstract: The beneficial impact of physical training in lowering cancer risk is well known. However, the precise mechanisms linking physical training and cancer are not fully understood. Skeletal muscle releases various myokines that seem to possess a direct anti-tumor effect. Although breast cancer (BC) is the prevalent form of cancer among women on a global scale, only limited data are available about the secretion of myokines following exercise in patients with BC. To study the effects of exercise on BC, the blood samples of patients with varied stages of BC were analyzed after 12 weeks of resistance training with whole-body electromyostimulation (WB-EMS). Following the training period, we observed that resistance training helps these patients to improve their physical characteristics and performance function by increasing skeletal muscle mass and strengthening their hand grip. Notably, the patient's serum was found to inhibit the growth and promote the apoptosis of BC cells in vitro. Moreover, the conditioned medium collected from in vitro stimulated human myotubes using electric pulse stimulation (EPS), an in vitro simulation of WB-EMS training, induced the cell death of BC cells. These results highlighted the direct cancer-protective effects of activated skeletal muscle. In line with our observed effects of serum from exercise-trained pancreatic and prostate cancer patients, the growth of BC cells was notably inhibited when supplemented directly with recombinant myokines C-X-C motif ligand 1 (CXCL1), Interleukin 10 (IL10), and C-C motif chemokine ligand 4 (CCL4). Notably, treatment with these myokines also increased the expression of caspase 3/7 (Casp3/7), resulting in enhanced BC cell death. Our data strongly suggest that physical exercise has a positive impact on skeletal muscle mass and hand grip strength in BC patients, along with a significant anti-tumor effect in BC cells. This shows promising potential for considering sports and physical training as supportive therapies for achieving more impactful cancer treatment. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=16616596&ISBN=&volume=25&issue=21&date=20241101&spage=11379&pages=11379-11396&title=International Journal of Molecular Sciences&atitle=The%20Influence%20of%20Physical%20Training%20on%20Breast%20Cancer%3A%20The%20Role%20of%20Exercise-Induced%20Myokines%20in%20Regulating%20Breast%20Cancer%20Cell%20Growth%20and%20Survival.&aulast=Natarajan%2C%20Anirudh&id=DOI:10.3390/ijms252111379
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 180779865
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The Influence of Physical Training on Breast Cancer: The Role of Exercise-Induced Myokines in Regulating Breast Cancer Cell Growth and Survival.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Natarajan%2C+Anirudh%22">Natarajan, Anirudh</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> anirudh.natarajan@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Pradhan%2C+Rashmita%22">Pradhan, Rashmita</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> rashmita.pradhan@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Dieterich%2C+Walburga%22">Dieterich, Walburga</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> walburga.dieterich@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Schwappacher%2C+Raphaela%22">Schwappacher, Raphaela</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> dejan.reljic@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Reljic%2C+Dejan%22">Reljic, Dejan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> hans.herrmann@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Herrmann%2C+Hans+J%2E%22">Herrmann, Hans J.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> markus.neurath@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Neurath%2C+Markus+F%2E%22">Neurath, Markus F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hack%2C+Carolin+C%2E%22">Hack, Carolin C.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> carolin.hack@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Beckmann%2C+Matthias+W%2E%22">Beckmann, Matthias W.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> fk-direktion@uk-erlangen.de</i><br /><searchLink fieldCode="AR" term="%22Zopf%2C+Yurdagül%22">Zopf, Yurdagül</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> yurdaguel.zopf@uk-erlangen.de</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Molecular+Sciences%22">International Journal of Molecular Sciences</searchLink>. Nov2024, Vol. 25 Issue 21, p11379. 18p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22EXERCISE+physiology%22">EXERCISE physiology</searchLink><br />*<searchLink fieldCode="DE" term="%22STRENGTH+training%22">STRENGTH training</searchLink><br />*<searchLink fieldCode="DE" term="%22RESISTANCE+training%22">RESISTANCE training</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+cell+growth%22">CANCER cell growth</searchLink><br />*<searchLink fieldCode="DE" term="%22MYOKINES%22">MYOKINES</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The beneficial impact of physical training in lowering cancer risk is well known. However, the precise mechanisms linking physical training and cancer are not fully understood. Skeletal muscle releases various myokines that seem to possess a direct anti-tumor effect. Although breast cancer (BC) is the prevalent form of cancer among women on a global scale, only limited data are available about the secretion of myokines following exercise in patients with BC. To study the effects of exercise on BC, the blood samples of patients with varied stages of BC were analyzed after 12 weeks of resistance training with whole-body electromyostimulation (WB-EMS). Following the training period, we observed that resistance training helps these patients to improve their physical characteristics and performance function by increasing skeletal muscle mass and strengthening their hand grip. Notably, the patient's serum was found to inhibit the growth and promote the apoptosis of BC cells in vitro. Moreover, the conditioned medium collected from in vitro stimulated human myotubes using electric pulse stimulation (EPS), an in vitro simulation of WB-EMS training, induced the cell death of BC cells. These results highlighted the direct cancer-protective effects of activated skeletal muscle. In line with our observed effects of serum from exercise-trained pancreatic and prostate cancer patients, the growth of BC cells was notably inhibited when supplemented directly with recombinant myokines C-X-C motif ligand 1 (CXCL1), Interleukin 10 (IL10), and C-C motif chemokine ligand 4 (CCL4). Notably, treatment with these myokines also increased the expression of caspase 3/7 (Casp3/7), resulting in enhanced BC cell death. Our data strongly suggest that physical exercise has a positive impact on skeletal muscle mass and hand grip strength in BC patients, along with a significant anti-tumor effect in BC cells. This shows promising potential for considering sports and physical training as supportive therapies for achieving more impactful cancer treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=180779865
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/ijms252111379
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 11379
    Subjects:
      – SubjectFull: EXERCISE physiology
        Type: general
      – SubjectFull: STRENGTH training
        Type: general
      – SubjectFull: RESISTANCE training
        Type: general
      – SubjectFull: CANCER cell growth
        Type: general
      – SubjectFull: MYOKINES
        Type: general
    Titles:
      – TitleFull: The Influence of Physical Training on Breast Cancer: The Role of Exercise-Induced Myokines in Regulating Breast Cancer Cell Growth and Survival.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Natarajan, Anirudh
      – PersonEntity:
          Name:
            NameFull: Pradhan, Rashmita
      – PersonEntity:
          Name:
            NameFull: Dieterich, Walburga
      – PersonEntity:
          Name:
            NameFull: Schwappacher, Raphaela
      – PersonEntity:
          Name:
            NameFull: Reljic, Dejan
      – PersonEntity:
          Name:
            NameFull: Herrmann, Hans J.
      – PersonEntity:
          Name:
            NameFull: Neurath, Markus F.
      – PersonEntity:
          Name:
            NameFull: Hack, Carolin C.
      – PersonEntity:
          Name:
            NameFull: Beckmann, Matthias W.
      – PersonEntity:
          Name:
            NameFull: Zopf, Yurdagül
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 16616596
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 21
          Titles:
            – TitleFull: International Journal of Molecular Sciences
              Type: main
ResultId 1