Academic Journal
View in EDS

Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-a]pyrimidine hybrids attached to arene units via methylene or azo linkage.

Bibliographic Details
Title: Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-a]pyrimidine hybrids attached to arene units via methylene or azo linkage.
Authors: Sanad, Sherif M. H.1 (AUTHOR) sherif_hamed1980@cu.edu.eg, Mekky, Ahmed E. M.1 (AUTHOR)
Source: Synthetic Communications. 2024, Vol. 54 Issue 21, p1857-1870. 14p.
Subject Terms: *ESCHERICHIA coli, *AZO compounds, *BENZOFURAN, *METHICILLIN-resistant staphylococcus aureus, *ANTIBACTERIAL agents, *LINEZOLID
Abstract: MRSA, a resistant bacteria causing severe infections, is targeted by researchers developing new anti-resistance compounds. The study aimed to investigate the MRSA inhibitory activity of two series of benzofuran-pyrazolo[1,5-a]pyrimidines 1 and 2, attached to arene units via methylene or azo linkage, respectively. The desired products were prepared, in 82–92% yields, by reacting benzofuran-based enaminone 4 with the appropriate 1H-pyrazole-3,5-diamines 5 in pyridine at reflux for 5–6 h. The new hybrids showed a wide spectrum of antibacterial activity against different ATCC strains. Products with azo linkage and para-substituted arene units with electron-releasing groups demonstrated higher antibacterial activity. 3-((4-Methoxyphenyl)diazenyl)-linked pyrazolo[1,5-a]pyrimidine 2e demonstrates activity that exceeded the reference ciprofloxacin with MIC/MBC values of 1.8/3.6 µM against S. aureus and E. coli strains. Also, it demonstrated more effective MRSA inhibitory activity than the reference linezolid, with MIC/MBC values of 3.6/14.4 and 1.8/7.2 µM against MRSA ATCC:33591 and ATCC:43300 strains, respectively. [ABSTRACT FROM AUTHOR]
Copyright of Synthetic Communications is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=00397911&ISBN=&volume=54&issue=21&date=20241101&spage=1857&pages=1857-1870&title=Synthetic Communications&atitle=Potential%20MRSA%20inhibitory%20activity%20of%20some%20new%20benzofuran-pyrazolo%5B1%2C5-a%5Dpyrimidine%20hybrids%20attached%20to%20arene%20units%20via%20methylene%20or%20azo%20linkage.&aulast=Sanad%2C%20Sherif%20M.%20H.&id=DOI:10.1080/00397911.2024.2409875
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 180406289
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-a]pyrimidine hybrids attached to arene units via methylene or azo linkage.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Sanad%2C+Sherif+M%2E+H%2E%22">Sanad, Sherif M. H.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sherif_hamed1980@cu.edu.eg</i><br /><searchLink fieldCode="AR" term="%22Mekky%2C+Ahmed+E%2E+M%2E%22">Mekky, Ahmed E. M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Synthetic+Communications%22">Synthetic Communications</searchLink>. 2024, Vol. 54 Issue 21, p1857-1870. 14p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22ESCHERICHIA+coli%22">ESCHERICHIA coli</searchLink><br />*<searchLink fieldCode="DE" term="%22AZO+compounds%22">AZO compounds</searchLink><br />*<searchLink fieldCode="DE" term="%22BENZOFURAN%22">BENZOFURAN</searchLink><br />*<searchLink fieldCode="DE" term="%22METHICILLIN-resistant+staphylococcus+aureus%22">METHICILLIN-resistant staphylococcus aureus</searchLink><br />*<searchLink fieldCode="DE" term="%22ANTIBACTERIAL+agents%22">ANTIBACTERIAL agents</searchLink><br />*<searchLink fieldCode="DE" term="%22LINEZOLID%22">LINEZOLID</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: MRSA, a resistant bacteria causing severe infections, is targeted by researchers developing new anti-resistance compounds. The study aimed to investigate the MRSA inhibitory activity of two series of benzofuran-pyrazolo[1,5-a]pyrimidines 1 and 2, attached to arene units via methylene or azo linkage, respectively. The desired products were prepared, in 82–92% yields, by reacting benzofuran-based enaminone 4 with the appropriate 1H-pyrazole-3,5-diamines 5 in pyridine at reflux for 5–6 h. The new hybrids showed a wide spectrum of antibacterial activity against different ATCC strains. Products with azo linkage and para-substituted arene units with electron-releasing groups demonstrated higher antibacterial activity. 3-((4-Methoxyphenyl)diazenyl)-linked pyrazolo[1,5-a]pyrimidine 2e demonstrates activity that exceeded the reference ciprofloxacin with MIC/MBC values of 1.8/3.6 µM against S. aureus and E. coli strains. Also, it demonstrated more effective MRSA inhibitory activity than the reference linezolid, with MIC/MBC values of 3.6/14.4 and 1.8/7.2 µM against MRSA ATCC:33591 and ATCC:43300 strains, respectively. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Synthetic Communications is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=180406289
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00397911.2024.2409875
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 1857
    Subjects:
      – SubjectFull: ESCHERICHIA coli
        Type: general
      – SubjectFull: AZO compounds
        Type: general
      – SubjectFull: BENZOFURAN
        Type: general
      – SubjectFull: METHICILLIN-resistant staphylococcus aureus
        Type: general
      – SubjectFull: ANTIBACTERIAL agents
        Type: general
      – SubjectFull: LINEZOLID
        Type: general
    Titles:
      – TitleFull: Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-a]pyrimidine hybrids attached to arene units via methylene or azo linkage.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sanad, Sherif M. H.
      – PersonEntity:
          Name:
            NameFull: Mekky, Ahmed E. M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00397911
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 21
          Titles:
            – TitleFull: Synthetic Communications
              Type: main
ResultId 1