Toddler hair cortisol levels are associated with maternal prenatal depression.
| Title: | Toddler hair cortisol levels are associated with maternal prenatal depression. |
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| Authors: | Thayer, Zaneta M.1 (AUTHOR) zaneta.thayer@dartmouth.edu, Nemeth, Katherine L.2 (AUTHOR), Beauregard, Jade A.2 (AUTHOR), Gildner, Theresa E.2 (AUTHOR) |
| Source: | American Journal of Human Biology. Oct2024, Vol. 36 Issue 10, p1-5. 5p. |
| Subject Terms: | *PRENATAL depression, *DEPRESSION in women, *MENTAL depression, *HYDROCORTISONE, *TODDLERS |
| Abstract: | Objectives: Cortisol is an important metabolic hormone that regulates multiple physiologic systems. Cortisol metabolism is sensitive to early life environments, including that experienced prenatally. Limited research has evaluated factors that predict variation in maternal and offspring toddler hair cortisol, which is important since hair cortisol represents different dynamics of hypothalamic pituitary adrenal (HPA)‐axis function than more common salivary or serum measures. Methods: To address this gap, we longitudinally evaluated whether maternal depression measured in pregnancy and 1 month postnatal was associated with maternal and offspring hair cortisol levels approximately 15 months after birth (n = 46 mothers, 40 toddlers; mean 15.6 months postnatal, SD = 2.9 months). Results: Mean depression symptoms were highest during the prenatal period. Prenatal, but not postnatal, maternal depression was associated with offspring hair cortisol levels (B = 0.095, p =.01). Maternal hair cortisol was not associated with depression measured at either time point. Conclusions: These findings indicate that offspring hair cortisol more than a year after birth is associated with maternal prenatal depression, consistent with previous research in salivary cortisol, suggesting that long‐term offspring stress physiology may be influenced by conditions experienced in utero. These findings highlight the potential for hair cortisol—a minimally invasive and easy‐to‐collect measure— to index toddler HPA‐axis dynamics. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Toddler hair cortisol levels are associated with maternal prenatal depression. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Thayer%2C+Zaneta+M%2E%22">Thayer, Zaneta M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zaneta.thayer@dartmouth.edu</i><br /><searchLink fieldCode="AR" term="%22Nemeth%2C+Katherine+L%2E%22">Nemeth, Katherine L.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beauregard%2C+Jade+A%2E%22">Beauregard, Jade A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gildner%2C+Theresa+E%2E%22">Gildner, Theresa E.</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Human+Biology%22">American Journal of Human Biology</searchLink>. Oct2024, Vol. 36 Issue 10, p1-5. 5p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22PRENATAL+depression%22">PRENATAL depression</searchLink><br />*<searchLink fieldCode="DE" term="%22DEPRESSION+in+women%22">DEPRESSION in women</searchLink><br />*<searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink><br />*<searchLink fieldCode="DE" term="%22HYDROCORTISONE%22">HYDROCORTISONE</searchLink><br />*<searchLink fieldCode="DE" term="%22TODDLERS%22">TODDLERS</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: Cortisol is an important metabolic hormone that regulates multiple physiologic systems. Cortisol metabolism is sensitive to early life environments, including that experienced prenatally. Limited research has evaluated factors that predict variation in maternal and offspring toddler hair cortisol, which is important since hair cortisol represents different dynamics of hypothalamic pituitary adrenal (HPA)‐axis function than more common salivary or serum measures. Methods: To address this gap, we longitudinally evaluated whether maternal depression measured in pregnancy and 1 month postnatal was associated with maternal and offspring hair cortisol levels approximately 15 months after birth (n = 46 mothers, 40 toddlers; mean 15.6 months postnatal, SD = 2.9 months). Results: Mean depression symptoms were highest during the prenatal period. Prenatal, but not postnatal, maternal depression was associated with offspring hair cortisol levels (B = 0.095, p =.01). Maternal hair cortisol was not associated with depression measured at either time point. Conclusions: These findings indicate that offspring hair cortisol more than a year after birth is associated with maternal prenatal depression, consistent with previous research in salivary cortisol, suggesting that long‐term offspring stress physiology may be influenced by conditions experienced in utero. These findings highlight the potential for hair cortisol—a minimally invasive and easy‐to‐collect measure— to index toddler HPA‐axis dynamics. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Human Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/ajhb.24127 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1 Subjects: – SubjectFull: PRENATAL depression Type: general – SubjectFull: DEPRESSION in women Type: general – SubjectFull: MENTAL depression Type: general – SubjectFull: HYDROCORTISONE Type: general – SubjectFull: TODDLERS Type: general Titles: – TitleFull: Toddler hair cortisol levels are associated with maternal prenatal depression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Thayer, Zaneta M. – PersonEntity: Name: NameFull: Nemeth, Katherine L. – PersonEntity: Name: NameFull: Beauregard, Jade A. – PersonEntity: Name: NameFull: Gildner, Theresa E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 10420533 Numbering: – Type: volume Value: 36 – Type: issue Value: 10 Titles: – TitleFull: American Journal of Human Biology Type: main |
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