Une cause rare d'hypercorticisme: un phéochromocytome sécrétant l'ACTH (à propos d'un cas).
| Title: | Une cause rare d'hypercorticisme: un phéochromocytome sécrétant l'ACTH (à propos d'un cas). |
|---|---|
| Alternate Title: | A rare cause of hypercorticism: ACTH-secreting pheochromocytoma (a case report). |
| Authors: | Rifai, Kaoutar1 rifaikaoutar@hotmail.fr, Toulali, Fatima1, Iraqi, Hinde1, Ettaik, Meryeme1, Gharbi, Mohamed El Hassan1 |
| Source: | Pan African Medical Journal. Jan-Apr2024, Vol. 47, p1-8. 8p. |
| Subject Terms: | *CUSHING'S syndrome, *ADRENOCORTICOTROPIC hormone, *HYDROCORTISONE, *HYPERTENSION, *PHEOCHROMOCYTOMA |
| Abstract (English): | La sécrétion ectopique d'Adrenocorticotropic hormone (ACTH) par un phéochromocytome est une cause très rare du syndrome de Cushing, posant des difficultés diagnostiques et thérapeutiques. Nous rapportons le cas d'une patiente chez qui ce diagnostic a été suspecté devant un syndrome de Cushing sévère associé à une mélanodermie, une hypertension artérielle résistante à une trithérapie et un diabète déséquilibré sous insulinothérapie. Biologiquement, les dérivés méthoxylés urinaires, le cortisol libre urinaire de 24 heures ainsi que l'ACTH étaient très élevés. L'imagerie a montré une masse surrénalienne gauche de 3,5 cm. La patiente a bénéficié d'une surrénalectomie gauche après une préparation médicale avec une bonne évolution clinico-biologique. L'étude anatomopathologique a confirmé le diagnostic de phéochromocytome. Notre cas illustre l'intérêt du dosage des dérivés methoxylés devant tout syndrome de Cushing ACTH dépendant associé à une masse surrénalienne. Ceci dans le but d'assurer une prise en charge précoce et d'éviter les complications pouvant engager le pronostic vital. [ABSTRACT FROM AUTHOR] |
| Abstract (French): | Ectopic ACTH-secreting pheochromocytoma is a very rare cause of Cushing's syndrome, posing diagnostic and therapeutic challenges. We here report the case of a female patient with suspected severe Cushing's syndrome associated with melanoderma, arterial hypertension resistant to triple therapy and unbalanced diabetes treated with insulin therapy. Biologically, urinary ethoxylated, 24-hour urinary free cortisol and ACTH were very high. Imaging showed a 3.5 cm left adrenal mass. The patient underwent left adrenalectomy after medical preparation, with good clinico-biological outcome. Anatomopathological examination confirmed the diagnosis of pheochromocytoma. This case study highlights the importance of measuring methoxylated derivatives in any patient with ACTH-dependent Cushing's syndrome associated with an adrenal mass. The aim is to ensure early treatment and avoid life-threatening complications. [ABSTRACT FROM AUTHOR] |
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| Database: | Academic Search Complete |
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| Items | – Name: Title Label: Title Group: Ti Data: Une cause rare d'hypercorticisme: un phéochromocytome sécrétant l'ACTH (à propos d'un cas). – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: A rare cause of hypercorticism: ACTH-secreting pheochromocytoma (a case report). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rifai%2C+Kaoutar%22">Rifai, Kaoutar</searchLink><relatesTo>1</relatesTo><i> rifaikaoutar@hotmail.fr</i><br /><searchLink fieldCode="AR" term="%22Toulali%2C+Fatima%22">Toulali, Fatima</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Iraqi%2C+Hinde%22">Iraqi, Hinde</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ettaik%2C+Meryeme%22">Ettaik, Meryeme</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gharbi%2C+Mohamed+El+Hassan%22">Gharbi, Mohamed El Hassan</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pan+African+Medical+Journal%22">Pan African Medical Journal</searchLink>. Jan-Apr2024, Vol. 47, p1-8. 8p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22CUSHING'S+syndrome%22">CUSHING'S syndrome</searchLink><br />*<searchLink fieldCode="DE" term="%22ADRENOCORTICOTROPIC+hormone%22">ADRENOCORTICOTROPIC hormone</searchLink><br />*<searchLink fieldCode="DE" term="%22HYDROCORTISONE%22">HYDROCORTISONE</searchLink><br />*<searchLink fieldCode="DE" term="%22HYPERTENSION%22">HYPERTENSION</searchLink><br />*<searchLink fieldCode="DE" term="%22PHEOCHROMOCYTOMA%22">PHEOCHROMOCYTOMA</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: La sécrétion ectopique d'Adrenocorticotropic hormone (ACTH) par un phéochromocytome est une cause très rare du syndrome de Cushing, posant des difficultés diagnostiques et thérapeutiques. Nous rapportons le cas d'une patiente chez qui ce diagnostic a été suspecté devant un syndrome de Cushing sévère associé à une mélanodermie, une hypertension artérielle résistante à une trithérapie et un diabète déséquilibré sous insulinothérapie. Biologiquement, les dérivés méthoxylés urinaires, le cortisol libre urinaire de 24 heures ainsi que l'ACTH étaient très élevés. L'imagerie a montré une masse surrénalienne gauche de 3,5 cm. La patiente a bénéficié d'une surrénalectomie gauche après une préparation médicale avec une bonne évolution clinico-biologique. L'étude anatomopathologique a confirmé le diagnostic de phéochromocytome. Notre cas illustre l'intérêt du dosage des dérivés methoxylés devant tout syndrome de Cushing ACTH dépendant associé à une masse surrénalienne. Ceci dans le but d'assurer une prise en charge précoce et d'éviter les complications pouvant engager le pronostic vital. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (French) Group: Ab Data: Ectopic ACTH-secreting pheochromocytoma is a very rare cause of Cushing's syndrome, posing diagnostic and therapeutic challenges. We here report the case of a female patient with suspected severe Cushing's syndrome associated with melanoderma, arterial hypertension resistant to triple therapy and unbalanced diabetes treated with insulin therapy. Biologically, urinary ethoxylated, 24-hour urinary free cortisol and ACTH were very high. Imaging showed a 3.5 cm left adrenal mass. The patient underwent left adrenalectomy after medical preparation, with good clinico-biological outcome. Anatomopathological examination confirmed the diagnosis of pheochromocytoma. This case study highlights the importance of measuring methoxylated derivatives in any patient with ACTH-dependent Cushing's syndrome associated with an adrenal mass. The aim is to ensure early treatment and avoid life-threatening complications. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pan African Medical Journal is the property of Pan African Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.11604/pamj.2024.47.88.36616 Languages: – Code: fre Text: French PhysicalDescription: Pagination: PageCount: 8 StartPage: 1 Subjects: – SubjectFull: CUSHING'S syndrome Type: general – SubjectFull: ADRENOCORTICOTROPIC hormone Type: general – SubjectFull: HYDROCORTISONE Type: general – SubjectFull: HYPERTENSION Type: general – SubjectFull: PHEOCHROMOCYTOMA Type: general Titles: – TitleFull: Une cause rare d'hypercorticisme: un phéochromocytome sécrétant l'ACTH (à propos d'un cas). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rifai, Kaoutar – PersonEntity: Name: NameFull: Toulali, Fatima – PersonEntity: Name: NameFull: Iraqi, Hinde – PersonEntity: Name: NameFull: Ettaik, Meryeme – PersonEntity: Name: NameFull: Gharbi, Mohamed El Hassan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan-Apr2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 19378688 Numbering: – Type: volume Value: 47 Titles: – TitleFull: Pan African Medical Journal Type: main |
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