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Etiology and Biochemical Profile of Rickets in Tertiary Care Centres in Eastern India: A Retrospective Cross-sectional Study.

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Title: Etiology and Biochemical Profile of Rickets in Tertiary Care Centres in Eastern India: A Retrospective Cross-sectional Study.
Authors: Bhattacharjee, Rana1, Chakraborty, Partha P.1 docparthapc@yahoo.co.in, Agrawal, Neeti1, Roy, Ajitesh2, Maiti, Animesh1, Chowdhury, Subhankar3
Source: Indian Journal of Endocrinology & Metabolism. Mar/Apr2024, Vol. 28 Issue 2, p184-191. 10p.
Subject Terms: *RENAL osteodystrophy, *BODY mass index, *RICKETS, *ALKALINE phosphatase, *TERTIARY care
Abstract: Introduction: We aimed to describe the clinical, biochemical and etiological profile of patients referred with a provisional diagnosis of rickets in tertiary care centres. In addition, we tried to propose a diagnostic algorithm for the evaluation of such patients. Methods: This was a retrospective cross-sectional study conducted in two tertiary care centres of West Bengal. Data of patients were retrieved between 2014 and 2021. Results: Out of 101 children, 22 had conditions simulating rickets. Renal tubular acidosis (RTA) was the most common (53.2%) etiology of rickets, followed by phosphopenic rickets (PR) (22.8%) and calcipenic rickets (CR) (17.7%). The prevalence of true nutritional rickets (NR) was only 8.9%. Children with RTA had a significantly higher prevalence of chronic ill health (69%) and polyuria (95.2%). Weight standard deviation score (SDS) and body mass index (BMI) SDS scores were significantly lower in the RTA group compared to others. Around 90.5% of children with RTA, and none in the other groups, had hypokalemia. Biochemically, hypophosphatemia and elevated alkaline phosphatase (ALP) were present in all patients with PR and CR. Compared to CR, median serum phosphate was significantly lower in the PR group. A significant difference in ALP values was noticed in patients with hypophosphatemia (815 ± 627 IU/L) compared to those without (279 ± 204 IU/L). Plasma parathyroid hormone (PTH) of 100 pg/ml seemed useful to differentiate CR from other forms. Conclusion: NR is uncommon in tertiary care centres. Children with rickets should be approached systematically with the estimation of ALP, phosphorus, creatinine, calcium, PTH and 25-hydroxy vitamin D to reach an etiological diagnosis. [ABSTRACT FROM AUTHOR]
Copyright of Indian Journal of Endocrinology & Metabolism is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Etiology and Biochemical Profile of Rickets in Tertiary Care Centres in Eastern India: A Retrospective Cross-sectional Study.
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  Data: <searchLink fieldCode="JN" term="%22Indian+Journal+of+Endocrinology+%26+Metabolism%22">Indian Journal of Endocrinology & Metabolism</searchLink>. Mar/Apr2024, Vol. 28 Issue 2, p184-191. 10p.
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  Data: *<searchLink fieldCode="DE" term="%22RENAL+osteodystrophy%22">RENAL osteodystrophy</searchLink><br />*<searchLink fieldCode="DE" term="%22BODY+mass+index%22">BODY mass index</searchLink><br />*<searchLink fieldCode="DE" term="%22RICKETS%22">RICKETS</searchLink><br />*<searchLink fieldCode="DE" term="%22ALKALINE+phosphatase%22">ALKALINE phosphatase</searchLink><br />*<searchLink fieldCode="DE" term="%22TERTIARY+care%22">TERTIARY care</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: We aimed to describe the clinical, biochemical and etiological profile of patients referred with a provisional diagnosis of rickets in tertiary care centres. In addition, we tried to propose a diagnostic algorithm for the evaluation of such patients. Methods: This was a retrospective cross-sectional study conducted in two tertiary care centres of West Bengal. Data of patients were retrieved between 2014 and 2021. Results: Out of 101 children, 22 had conditions simulating rickets. Renal tubular acidosis (RTA) was the most common (53.2%) etiology of rickets, followed by phosphopenic rickets (PR) (22.8%) and calcipenic rickets (CR) (17.7%). The prevalence of true nutritional rickets (NR) was only 8.9%. Children with RTA had a significantly higher prevalence of chronic ill health (69%) and polyuria (95.2%). Weight standard deviation score (SDS) and body mass index (BMI) SDS scores were significantly lower in the RTA group compared to others. Around 90.5% of children with RTA, and none in the other groups, had hypokalemia. Biochemically, hypophosphatemia and elevated alkaline phosphatase (ALP) were present in all patients with PR and CR. Compared to CR, median serum phosphate was significantly lower in the PR group. A significant difference in ALP values was noticed in patients with hypophosphatemia (815 ± 627 IU/L) compared to those without (279 ± 204 IU/L). Plasma parathyroid hormone (PTH) of 100 pg/ml seemed useful to differentiate CR from other forms. Conclusion: NR is uncommon in tertiary care centres. Children with rickets should be approached systematically with the estimation of ALP, phosphorus, creatinine, calcium, PTH and 25-hydroxy vitamin D to reach an etiological diagnosis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Indian Journal of Endocrinology & Metabolism is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.4103/ijem.ijem_221_23
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 184
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      – SubjectFull: RENAL osteodystrophy
        Type: general
      – SubjectFull: BODY mass index
        Type: general
      – SubjectFull: RICKETS
        Type: general
      – SubjectFull: ALKALINE phosphatase
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      – SubjectFull: TERTIARY care
        Type: general
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      – TitleFull: Etiology and Biochemical Profile of Rickets in Tertiary Care Centres in Eastern India: A Retrospective Cross-sectional Study.
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            NameFull: Bhattacharjee, Rana
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              Text: Mar/Apr2024
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