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Systemic Inflammatory Changes in Spinal Cord Injured Patients after Adding Aquatic Therapy to Standard Physiotherapy Treatment.

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Title: Systemic Inflammatory Changes in Spinal Cord Injured Patients after Adding Aquatic Therapy to Standard Physiotherapy Treatment.
Authors: Agulló-Ortuño, María. Teresa1,2 (AUTHOR) mariateresa.agullo@uclm.es, Romay-Barrero, Helena1,2 (AUTHOR) helena.romay@uclm.es, Lambeck, Johan3 (AUTHOR) lambeck.hydro@freeler.nl, Blanco-Calonge, Juan M.1,2 (AUTHOR) ruben.arroyo@uclm.es, Arroyo-Fernández, Rubén1,2 (AUTHOR) gonzalo.melgar@uclm.es, Geigle, Paula Richley4 (AUTHOR) geigle@comcast.net, Menchero, Raquel2 (AUTHOR), Corral, Gonzalo Melgar del1,2 (AUTHOR) ines.martinez@uclm.es, Martínez-Galán, Inés1,2 (AUTHOR)
Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7961. 15p.
Subject Terms: *HYDROTHERAPY, *SPINAL cord, *PHYSICAL therapy, *SPINAL cord injuries, *INFLAMMATION
Abstract: Spinal cord injury (SCI) is a severe medical condition resulting in substantial physiological and functional consequences for the individual. People with SCI are characterised by a chronic, low-grade systemic inflammatory state, which contributes to further undesirable secondary injuries. This study aimed to evaluate the effect of adding aquatic therapy to the standard physiotherapy treatment, implemented in two different schedules, on systemic inflammation in SCI patients. Additionally, the relationship between cytokine blood levels and changes in functionality (measured with the 6MWT, 10MWT, WISCI, BBS, and TUG tests) throughout the study was assessed. A quantitative multiplexed antibody assay was performed to measure the expression level of 20 pro- and anti-inflammatory cytokines in blood samples from SCI patients at three time points: baseline, week 6, and immediately post-intervention (week 12). This study identified a complex signature of five cytokines (IL-12p70, IL-8, MCP-1, IL-1α, and IP10) associated with the time course of the two physiotherapy programs. Two other cytokines (IL-4 and TNF-α) were also associated with the functional recovery of patients. These could be important indicators for SCI prognosis and provide a basis for developing novel targeted therapies. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Systemic Inflammatory Changes in Spinal Cord Injured Patients after Adding Aquatic Therapy to Standard Physiotherapy Treatment.
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  Data: <searchLink fieldCode="AR" term="%22Agulló-Ortuño%2C+María%2E+Teresa%22">Agulló-Ortuño, María. Teresa</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> mariateresa.agullo@uclm.es</i><br /><searchLink fieldCode="AR" term="%22Romay-Barrero%2C+Helena%22">Romay-Barrero, Helena</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> helena.romay@uclm.es</i><br /><searchLink fieldCode="AR" term="%22Lambeck%2C+Johan%22">Lambeck, Johan</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> lambeck.hydro@freeler.nl</i><br /><searchLink fieldCode="AR" term="%22Blanco-Calonge%2C+Juan+M%2E%22">Blanco-Calonge, Juan M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> ruben.arroyo@uclm.es</i><br /><searchLink fieldCode="AR" term="%22Arroyo-Fernández%2C+Rubén%22">Arroyo-Fernández, Rubén</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> gonzalo.melgar@uclm.es</i><br /><searchLink fieldCode="AR" term="%22Geigle%2C+Paula+Richley%22">Geigle, Paula Richley</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> geigle@comcast.net</i><br /><searchLink fieldCode="AR" term="%22Menchero%2C+Raquel%22">Menchero, Raquel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Corral%2C+Gonzalo+Melgar+del%22">Corral, Gonzalo Melgar del</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> ines.martinez@uclm.es</i><br /><searchLink fieldCode="AR" term="%22Martínez-Galán%2C+Inés%22">Martínez-Galán, Inés</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Molecular+Sciences%22">International Journal of Molecular Sciences</searchLink>. Jul2024, Vol. 25 Issue 14, p7961. 15p.
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  Data: *<searchLink fieldCode="DE" term="%22HYDROTHERAPY%22">HYDROTHERAPY</searchLink><br />*<searchLink fieldCode="DE" term="%22SPINAL+cord%22">SPINAL cord</searchLink><br />*<searchLink fieldCode="DE" term="%22PHYSICAL+therapy%22">PHYSICAL therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22SPINAL+cord+injuries%22">SPINAL cord injuries</searchLink><br />*<searchLink fieldCode="DE" term="%22INFLAMMATION%22">INFLAMMATION</searchLink>
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  Data: Spinal cord injury (SCI) is a severe medical condition resulting in substantial physiological and functional consequences for the individual. People with SCI are characterised by a chronic, low-grade systemic inflammatory state, which contributes to further undesirable secondary injuries. This study aimed to evaluate the effect of adding aquatic therapy to the standard physiotherapy treatment, implemented in two different schedules, on systemic inflammation in SCI patients. Additionally, the relationship between cytokine blood levels and changes in functionality (measured with the 6MWT, 10MWT, WISCI, BBS, and TUG tests) throughout the study was assessed. A quantitative multiplexed antibody assay was performed to measure the expression level of 20 pro- and anti-inflammatory cytokines in blood samples from SCI patients at three time points: baseline, week 6, and immediately post-intervention (week 12). This study identified a complex signature of five cytokines (IL-12p70, IL-8, MCP-1, IL-1α, and IP10) associated with the time course of the two physiotherapy programs. Two other cytokines (IL-4 and TNF-α) were also associated with the functional recovery of patients. These could be important indicators for SCI prognosis and provide a basis for developing novel targeted therapies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/ijms25147961
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        Text: English
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        PageCount: 15
        StartPage: 7961
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      – SubjectFull: HYDROTHERAPY
        Type: general
      – SubjectFull: SPINAL cord
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      – SubjectFull: PHYSICAL therapy
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              Text: Jul2024
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