Comparing 2-dimensional macular pigment optical density with objective and subjective perimetry and visual acuity in age-related macular degeneration.
| Title: | Comparing 2-dimensional macular pigment optical density with objective and subjective perimetry and visual acuity in age-related macular degeneration. |
|---|---|
| Authors: | Rai, Bhim B.1 (AUTHOR) bhim.rai@anu.edu.au, Sabeti, Faran1,2 (AUTHOR), van Kleef, Joshua P.1 (AUTHOR), Carle, Corinne F.1 (AUTHOR), Rohan, Emilie M. F.1 (AUTHOR), Essex, Rohan W.3 (AUTHOR), Barry, Richard C.4 (AUTHOR), Maddess, Ted1 (AUTHOR) |
| Source: | Graefe's Archive of Clinical & Experimental Ophthalmology. Aug2024, Vol. 262 Issue 8, p2449-2459. 11p. |
| Subject Terms: | *MACULAR degeneration, *VISUAL acuity, *PERIMETRY, *OPACITY (Optics), *OPTICAL coherence tomography |
| Abstract: | Purpose: To compare diagnostic power for different severities of age-related macular degeneration (AMD) of two-dimensional macular pigment optical densities (2D-MPOD) and spatially matched objective perimetry, with standard perimetry and best-corrected visual acuity (BCVA). Methods: The ObjectiveField Analyser (OFA) provided objective perimetry, and a Heidelberg Spectralis optical coherence tomography (OCT) measured 2D-MPOD in AMD patients, both completed twice over 0.99 ± 0.16 years. From each 2D-MPOD image, we extracted 20 regions/macula, matched to the 20 OFA stimuli/macula. For each region, we calculated 7 measures from the 2D-MPOD pixel values and correlated those with OFA sensitivities and delays. We quantified 2D-MPOD changes, the ability of 2D-MPOD and OFA to discriminate AMD stages, and the discriminatory power of Matrix perimetry and BCVA using percentage area under receiver operator characteristic plots (%AUROC). Results: In 58 eyes of 29 subjects (71.6 ± 6.3 years, 22 females), we found significant correlations between 2D-MPOD and OFA sensitivities for Age-Related Eye Disease Studies (AREDS)-3 and AREDS-4 severities. Delays showed significant correlations with AREDS-2. For AREDS-4, correlations extended across all eccentricities. Regression associated with the Bland–Altman plots showed significant changes in 2D-MPOD over the study period, especially variability measures. MPOD per-region medians discriminated AREDS-1 from AREDS-3 eyes at a %AUROC of 80.0 ± 6.3%, outperforming OFA, Matrix perimetry, and BCVA. Conclusions: MPOD changes correlated with central functional changes and significant correlations extended peripherally in later-stage AMD. Good diagnostic power for earlier-stage AMD and significant change over the study suggest that 2D-MPOD and OFA may provide effective biomarkers. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparing 2-dimensional macular pigment optical density with objective and subjective perimetry and visual acuity in age-related macular degeneration. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rai%2C+Bhim+B%2E%22">Rai, Bhim B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> bhim.rai@anu.edu.au</i><br /><searchLink fieldCode="AR" term="%22Sabeti%2C+Faran%22">Sabeti, Faran</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Kleef%2C+Joshua+P%2E%22">van Kleef, Joshua P.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carle%2C+Corinne+F%2E%22">Carle, Corinne F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rohan%2C+Emilie+M%2E+F%2E%22">Rohan, Emilie M. F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Essex%2C+Rohan+W%2E%22">Essex, Rohan W.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barry%2C+Richard+C%2E%22">Barry, Richard C.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maddess%2C+Ted%22">Maddess, Ted</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Graefe's+Archive+of+Clinical+%26+Experimental+Ophthalmology%22">Graefe's Archive of Clinical & Experimental Ophthalmology</searchLink>. Aug2024, Vol. 262 Issue 8, p2449-2459. 11p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22MACULAR+degeneration%22">MACULAR degeneration</searchLink><br />*<searchLink fieldCode="DE" term="%22VISUAL+acuity%22">VISUAL acuity</searchLink><br />*<searchLink fieldCode="DE" term="%22PERIMETRY%22">PERIMETRY</searchLink><br />*<searchLink fieldCode="DE" term="%22OPACITY+%28Optics%29%22">OPACITY (Optics)</searchLink><br />*<searchLink fieldCode="DE" term="%22OPTICAL+coherence+tomography%22">OPTICAL coherence tomography</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To compare diagnostic power for different severities of age-related macular degeneration (AMD) of two-dimensional macular pigment optical densities (2D-MPOD) and spatially matched objective perimetry, with standard perimetry and best-corrected visual acuity (BCVA). Methods: The ObjectiveField Analyser (OFA) provided objective perimetry, and a Heidelberg Spectralis optical coherence tomography (OCT) measured 2D-MPOD in AMD patients, both completed twice over 0.99 ± 0.16 years. From each 2D-MPOD image, we extracted 20 regions/macula, matched to the 20 OFA stimuli/macula. For each region, we calculated 7 measures from the 2D-MPOD pixel values and correlated those with OFA sensitivities and delays. We quantified 2D-MPOD changes, the ability of 2D-MPOD and OFA to discriminate AMD stages, and the discriminatory power of Matrix perimetry and BCVA using percentage area under receiver operator characteristic plots (%AUROC). Results: In 58 eyes of 29 subjects (71.6 ± 6.3 years, 22 females), we found significant correlations between 2D-MPOD and OFA sensitivities for Age-Related Eye Disease Studies (AREDS)-3 and AREDS-4 severities. Delays showed significant correlations with AREDS-2. For AREDS-4, correlations extended across all eccentricities. Regression associated with the Bland–Altman plots showed significant changes in 2D-MPOD over the study period, especially variability measures. MPOD per-region medians discriminated AREDS-1 from AREDS-3 eyes at a %AUROC of 80.0 ± 6.3%, outperforming OFA, Matrix perimetry, and BCVA. Conclusions: MPOD changes correlated with central functional changes and significant correlations extended peripherally in later-stage AMD. Good diagnostic power for earlier-stage AMD and significant change over the study suggest that 2D-MPOD and OFA may provide effective biomarkers. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Graefe's Archive of Clinical & Experimental Ophthalmology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00417-024-06437-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 2449 Subjects: – SubjectFull: MACULAR degeneration Type: general – SubjectFull: VISUAL acuity Type: general – SubjectFull: PERIMETRY Type: general – SubjectFull: OPACITY (Optics) Type: general – SubjectFull: OPTICAL coherence tomography Type: general Titles: – TitleFull: Comparing 2-dimensional macular pigment optical density with objective and subjective perimetry and visual acuity in age-related macular degeneration. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rai, Bhim B. – PersonEntity: Name: NameFull: Sabeti, Faran – PersonEntity: Name: NameFull: van Kleef, Joshua P. – PersonEntity: Name: NameFull: Carle, Corinne F. – PersonEntity: Name: NameFull: Rohan, Emilie M. F. – PersonEntity: Name: NameFull: Essex, Rohan W. – PersonEntity: Name: NameFull: Barry, Richard C. – PersonEntity: Name: NameFull: Maddess, Ted IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0721832X Numbering: – Type: volume Value: 262 – Type: issue Value: 8 Titles: – TitleFull: Graefe's Archive of Clinical & Experimental Ophthalmology Type: main |
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