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Betaine and I-LG may have a predictive value for ATB: A causal study in a large European population.

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Title: Betaine and I-LG may have a predictive value for ATB: A causal study in a large European population.
Authors: Xian, Xiaomin1 (AUTHOR), Li, Li2 (AUTHOR), Ye, Jing3 (AUTHOR), Mo, Wenxiu4 (AUTHOR), Liang, Dabin3 (AUTHOR), Huang, Minying3 (AUTHOR), Chang, Yue5 (AUTHOR) czz6997@163.com, Cui, Zhezhe1,3 (AUTHOR) czz6997@163.com
Source: PLoS ONE. 7/5/2024, Vol. 19 Issue 7, p1-18. 18p.
Subject Terms: *BETAINE, *FATTY acid oxidation, *GENOME-wide association studies, *METHIONINE metabolism, *SINGLE nucleotide polymorphisms, *ANTITUBERCULAR agents
Abstract: Purpose: To analyze the causal relationship between 486 human serum metabolites and the active tuberculosis (ATB) in European population. Methods: In this study, the causal relationship between human serum metabolites and the ATB was analyzed by integrating the genome-wide association study (GWAS). The 486 human serum metabolites were used as the exposure variable, three different ATB GWAS databases in the European population were set as outcome variables, and single nucleotide polymorphisms were used as instrumental variables for Mendelian Randomization. The inverse variance weighting was estimated causality, the MR-Egger intercept to estimate horizontal pleiotropy, and the combined effects of metabolites were also considered in the meta-analysis. Furthermore, the web-based MetaboAnalyst 6.0 was engaged for enrichment pathway analysis, while R (version 4.3.2) software and Review Manager 5.3 were employed for statistical analysis. Results: A total of 21, 17, and 19 metabolites strongly associated with ATB were found in the three databases after preliminary screening (P < 0.05). The intersecting metabolites across these databases included tryptophan, betaine, 1-linoleoylglycerol (1-monolinolein) (1-LG), 1-eicosatrienoylglycerophosphocholine, and oleoylcarnitine. Among them, betaine (I2 = 24%, P = 0.27) and 1-LG (I2 = 0%, P = 0.62) showed the lowest heterogeneity among the different ATB databases. In addition, the metabolic pathways of phosphatidylethanolamine biosynthesis (P = 0.0068), methionine metabolism (P = 0.0089), betaine metabolism (P = 0.0205) and oxidation of branched-chain fatty acids (P = 0.0309) were also associated with ATB. Conclusion: Betaine and 1-LG may be biomarkers or auxiliary diagnostic tools for ATB. They may provide new guidance for medical practice in the early diagnosis and surveillance of ATB. In addition, by interfering with phosphatidylethanolamine biosynthesis, methionine metabolism, betaine metabolism, oxidation of branched-chain fatty acids, and other pathways, it is helpful to develop new anti-tuberculosis drugs and explore the virulence or pathogenesis of ATB at a deeper level, providing an effective reference for future studies. [ABSTRACT FROM AUTHOR]
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  Data: Betaine and I-LG may have a predictive value for ATB: A causal study in a large European population.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xian%2C+Xiaomin%22&quot;&gt;Xian, Xiaomin&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Li%22&quot;&gt;Li, Li&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ye%2C+Jing%22&quot;&gt;Ye, Jing&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mo%2C+Wenxiu%22&quot;&gt;Mo, Wenxiu&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liang%2C+Dabin%22&quot;&gt;Liang, Dabin&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huang%2C+Minying%22&quot;&gt;Huang, Minying&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chang%2C+Yue%22&quot;&gt;Chang, Yue&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; czz6997@163.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cui%2C+Zhezhe%22&quot;&gt;Cui, Zhezhe&lt;/searchLink&gt;&lt;relatesTo&gt;1,3&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; czz6997@163.com&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22PLoS+ONE%22&quot;&gt;PLoS ONE&lt;/searchLink&gt;. 7/5/2024, Vol. 19 Issue 7, p1-18. 18p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To analyze the causal relationship between 486 human serum metabolites and the active tuberculosis (ATB) in European population. Methods: In this study, the causal relationship between human serum metabolites and the ATB was analyzed by integrating the genome-wide association study (GWAS). The 486 human serum metabolites were used as the exposure variable, three different ATB GWAS databases in the European population were set as outcome variables, and single nucleotide polymorphisms were used as instrumental variables for Mendelian Randomization. The inverse variance weighting was estimated causality, the MR-Egger intercept to estimate horizontal pleiotropy, and the combined effects of metabolites were also considered in the meta-analysis. Furthermore, the web-based MetaboAnalyst 6.0 was engaged for enrichment pathway analysis, while R (version 4.3.2) software and Review Manager 5.3 were employed for statistical analysis. Results: A total of 21, 17, and 19 metabolites strongly associated with ATB were found in the three databases after preliminary screening (P &lt; 0.05). The intersecting metabolites across these databases included tryptophan, betaine, 1-linoleoylglycerol (1-monolinolein) (1-LG), 1-eicosatrienoylglycerophosphocholine, and oleoylcarnitine. Among them, betaine (I2 = 24%, P = 0.27) and 1-LG (I2 = 0%, P = 0.62) showed the lowest heterogeneity among the different ATB databases. In addition, the metabolic pathways of phosphatidylethanolamine biosynthesis (P = 0.0068), methionine metabolism (P = 0.0089), betaine metabolism (P = 0.0205) and oxidation of branched-chain fatty acids (P = 0.0309) were also associated with ATB. Conclusion: Betaine and 1-LG may be biomarkers or auxiliary diagnostic tools for ATB. They may provide new guidance for medical practice in the early diagnosis and surveillance of ATB. In addition, by interfering with phosphatidylethanolamine biosynthesis, methionine metabolism, betaine metabolism, oxidation of branched-chain fatty acids, and other pathways, it is helpful to develop new anti-tuberculosis drugs and explore the virulence or pathogenesis of ATB at a deeper level, providing an effective reference for future studies. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1371/journal.pone.0306752
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        Text: English
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      – SubjectFull: BETAINE
        Type: general
      – SubjectFull: FATTY acid oxidation
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      – SubjectFull: GENOME-wide association studies
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      – TitleFull: Betaine and I-LG may have a predictive value for ATB: A causal study in a large European population.
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              Text: 7/5/2024
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