Poxvirus Immune Evasion.
| Title: | Poxvirus Immune Evasion. |
|---|---|
| Authors: | Hernaez, Bruno1 (AUTHOR) bhernaez@cbm.csic.es, Alcamí, Antonio1 (AUTHOR) |
| Source: | Annual Review of Immunology. Apr2024, Vol. 42 Issue 1, p551-584. 23p. |
| Abstract: | Poxviruses have evolved a wide array of mechanisms to evade the immune response, and we provide an overview of the different immunomodulatory strategies. Poxviruses prevent the recognition of viral DNA that triggers the immune responses and inhibit signaling pathways within the infected cell. A unique feature of poxviruses is the production of secreted proteins that mimic cytokines and cytokine receptors, acting as decoy receptors to neutralize the activity of cytokines and chemokines. The capacity of these proteins to evade cellular immune responses by inhibiting cytokine activation is complemented by poxviruses' strategies to block natural killer cells and cytotoxic T cells, often through interfering with antigen presentation pathways. Mechanisms that target complement activation are also encoded by poxviruses. Virus-encoded proteins that target immune molecules and pathways play a major role in immune modulation, and their contribution to viral pathogenesis, facilitating virus replication or preventing immunopathology, is discussed. [ABSTRACT FROM AUTHOR] |
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| Database: | Academic Search Complete |
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| Header | DbId: a9h DbLabel: Academic Search Complete An: 178236019 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Poxvirus Immune Evasion. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hernaez%2C+Bruno%22">Hernaez, Bruno</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> bhernaez@cbm.csic.es</i><br /><searchLink fieldCode="AR" term="%22Alcamí%2C+Antonio%22">Alcamí, Antonio</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annual+Review+of+Immunology%22">Annual Review of Immunology</searchLink>. Apr2024, Vol. 42 Issue 1, p551-584. 23p. – Name: Abstract Label: Abstract Group: Ab Data: Poxviruses have evolved a wide array of mechanisms to evade the immune response, and we provide an overview of the different immunomodulatory strategies. Poxviruses prevent the recognition of viral DNA that triggers the immune responses and inhibit signaling pathways within the infected cell. A unique feature of poxviruses is the production of secreted proteins that mimic cytokines and cytokine receptors, acting as decoy receptors to neutralize the activity of cytokines and chemokines. The capacity of these proteins to evade cellular immune responses by inhibiting cytokine activation is complemented by poxviruses' strategies to block natural killer cells and cytotoxic T cells, often through interfering with antigen presentation pathways. Mechanisms that target complement activation are also encoded by poxviruses. Virus-encoded proteins that target immune molecules and pathways play a major role in immune modulation, and their contribution to viral pathogenesis, facilitating virus replication or preventing immunopathology, is discussed. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annual Review of Immunology is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1146/annurev-immunol-090222-110227 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 23 StartPage: 551 Titles: – TitleFull: Poxvirus Immune Evasion. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hernaez, Bruno – PersonEntity: Name: NameFull: Alcamí, Antonio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 07320582 Numbering: – Type: volume Value: 42 – Type: issue Value: 1 Titles: – TitleFull: Annual Review of Immunology Type: main |
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