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Prognostic Impact of Mucin Expression in Curatively Resected Ampulla of Vater Cancer.

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Title: Prognostic Impact of Mucin Expression in Curatively Resected Ampulla of Vater Cancer.
Authors: Noh, Byeong Gwan1 (AUTHOR) sagerbk@naver.com, Seo, Hyung Il1 (AUTHOR) pym777@hanmail.net, Park, Young Mok1 (AUTHOR) songsubin29@gmail.com, Song, Su-Bin1 (AUTHOR), Kim, Suk2 (AUTHOR) kimsuk8819@gmail.com, Hong, Seung Baek2 (AUTHOR) cinematiclife7@hanmail.net, Lee, Nam Kyung2 (AUTHOR) leenk77@hanmail.net, Lee, Jonghyun3 (AUTHOR) keiasikr@nate.com, Kim, Tae In3 (AUTHOR) zeitgeister88@daum.net, Kwon, Chae Hwa4 (AUTHOR) chkwon@pusan.ac.kr, Ahn, Ji Hyun5 (AUTHOR) jvcjh@naver.com
Source: Cancers. Jun2024, Vol. 16 Issue 11, p2120. 9p.
Subject Terms: *TISSUE arrays, *STATISTICAL correlation, *CANCER relapse, *RESEARCH funding, *GLYCOPROTEINS, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *MULTIVARIATE analysis, *GENE expression, *IMMUNOHISTOCHEMISTRY, *RESEARCH, *STATISTICS, BILE duct tumors
Abstract: Simple Summary: It is generally reported that the prognostic factors for ampulla of Vater cancer include T stage, N stage, and lymphovascular invasion and subtype, and the meaning of MUC stain is controversial. This retrospective study by the authors evaluated the significance of various MUC stains in AoV cancer using single-center clinicopathological data. The results showed that MUC5AC was significant for lymph node metastasis and was furthermore valuable as a prognostic factor for predicting overall survival. If this is evaluated in addition to the hematoxylin and eosin stain, which is commonly performed in preoperative biopsy, it is expected to be a method to select groups that require more extensive LN dissection and further prevent locoregional recurrence. Introduction: Mucins play a pivotal role in epithelial carcinogenesis; however, their role remains elusive in ampulla of Vater (AoV) cancer, regardless of histological subtype. Therefore, we investigated the clinical significance of MUC1, MUC2, MUC5AC, and MUC6 expression in AoV cancer. Methods: Using samples from 68 patients with AoV cancer, we performed immunohistochemical staining for MUC1, MUC2, MUC5AC, and MUC6 using a tissue microarray. Subsequently, we analyzed their expression patterns in relation to clinicopathological parameters and patient outcomes. Results: Of the patients, 98.5% exhibited positive expression for MUC1, while MUC2, MUC5AC, and MUC6 were expressed in 44.1%, 47.1%, and 41.2% of the patients, respectively. Correlation analyses between mucin expression and clinicopathological factors revealed no significant associations, except between MUC5AC expression and N stage. Univariate analysis demonstrated significant associations between MUC5AC expression and overall survival (OS). Multivariate analysis further confirmed that MUC5AC expression was a significant predictor of OS, along with the N stage. However, MUC5AC expression was not meaningfully associated with recurrence-free survival (RFS). The patients positive for MUC5AC expression had a considerably shorter OS than those with negative expression. Conclusions: Our study provides insights into the clinical impact of mucins on AoV cancer, regardless of the histological subtype. Although MUC1 expression is universal, MUC5AC expression is a significant prognostic indicator that correlates with lymph node metastasis and poor OS. These results emphasize the possible utility of MUC5AC as a biomarker for extensive lymph node dissection and the prognostic evaluation of patients with AoV cancer. [ABSTRACT FROM AUTHOR]
Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Prognostic Impact of Mucin Expression in Curatively Resected Ampulla of Vater Cancer.
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  Data: <searchLink fieldCode="AR" term="%22Noh%2C+Byeong+Gwan%22">Noh, Byeong Gwan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sagerbk@naver.com</i><br /><searchLink fieldCode="AR" term="%22Seo%2C+Hyung+Il%22">Seo, Hyung Il</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pym777@hanmail.net</i><br /><searchLink fieldCode="AR" term="%22Park%2C+Young+Mok%22">Park, Young Mok</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> songsubin29@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Song%2C+Su-Bin%22">Song, Su-Bin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Suk%22">Kim, Suk</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> kimsuk8819@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Hong%2C+Seung+Baek%22">Hong, Seung Baek</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> cinematiclife7@hanmail.net</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Nam+Kyung%22">Lee, Nam Kyung</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> leenk77@hanmail.net</i><br /><searchLink fieldCode="AR" term="%22Lee%2C+Jonghyun%22">Lee, Jonghyun</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> keiasikr@nate.com</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Tae+In%22">Kim, Tae In</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> zeitgeister88@daum.net</i><br /><searchLink fieldCode="AR" term="%22Kwon%2C+Chae+Hwa%22">Kwon, Chae Hwa</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> chkwon@pusan.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Ahn%2C+Ji+Hyun%22">Ahn, Ji Hyun</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> jvcjh@naver.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Cancers%22">Cancers</searchLink>. Jun2024, Vol. 16 Issue 11, p2120. 9p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Simple Summary: It is generally reported that the prognostic factors for ampulla of Vater cancer include T stage, N stage, and lymphovascular invasion and subtype, and the meaning of MUC stain is controversial. This retrospective study by the authors evaluated the significance of various MUC stains in AoV cancer using single-center clinicopathological data. The results showed that MUC5AC was significant for lymph node metastasis and was furthermore valuable as a prognostic factor for predicting overall survival. If this is evaluated in addition to the hematoxylin and eosin stain, which is commonly performed in preoperative biopsy, it is expected to be a method to select groups that require more extensive LN dissection and further prevent locoregional recurrence. Introduction: Mucins play a pivotal role in epithelial carcinogenesis; however, their role remains elusive in ampulla of Vater (AoV) cancer, regardless of histological subtype. Therefore, we investigated the clinical significance of MUC1, MUC2, MUC5AC, and MUC6 expression in AoV cancer. Methods: Using samples from 68 patients with AoV cancer, we performed immunohistochemical staining for MUC1, MUC2, MUC5AC, and MUC6 using a tissue microarray. Subsequently, we analyzed their expression patterns in relation to clinicopathological parameters and patient outcomes. Results: Of the patients, 98.5% exhibited positive expression for MUC1, while MUC2, MUC5AC, and MUC6 were expressed in 44.1%, 47.1%, and 41.2% of the patients, respectively. Correlation analyses between mucin expression and clinicopathological factors revealed no significant associations, except between MUC5AC expression and N stage. Univariate analysis demonstrated significant associations between MUC5AC expression and overall survival (OS). Multivariate analysis further confirmed that MUC5AC expression was a significant predictor of OS, along with the N stage. However, MUC5AC expression was not meaningfully associated with recurrence-free survival (RFS). The patients positive for MUC5AC expression had a considerably shorter OS than those with negative expression. Conclusions: Our study provides insights into the clinical impact of mucins on AoV cancer, regardless of the histological subtype. Although MUC1 expression is universal, MUC5AC expression is a significant prognostic indicator that correlates with lymph node metastasis and poor OS. These results emphasize the possible utility of MUC5AC as a biomarker for extensive lymph node dissection and the prognostic evaluation of patients with AoV cancer. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/cancers16112120
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        Text: English
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      – SubjectFull: DESCRIPTIVE statistics
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      – TitleFull: Prognostic Impact of Mucin Expression in Curatively Resected Ampulla of Vater Cancer.
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