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Substance P's Impact on Chronic Pain and Psychiatric Conditions—A Narrative Review.

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Title: Substance P's Impact on Chronic Pain and Psychiatric Conditions—A Narrative Review.
Authors: Humes, Charles1,2 (AUTHOR) charles.humes@my.rfums.org, Sic, Aleksandar1,3 (AUTHOR) aca.smed01@gmail.com, Knezevic, Nebojsa Nick1,4,5 (AUTHOR) nebojsa.knezevic@aah.org
Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5905. 17p.
Subject Terms: *SUBSTANCE P, *CHRONIC pain, *MENTAL illness, *ANXIETY disorders, *MENTAL depression
Abstract: Substance P (SP) plays a crucial role in pain modulation, with significant implications for major depressive disorder (MDD), anxiety disorders, and post-traumatic stress disorder (PTSD). Elevated SP levels are linked to heightened pain sensitivity and various psychiatric conditions, spurring interest in potential therapeutic interventions. In chronic pain, commonly associated with MDD and anxiety disorders, SP emerges as a key mediator in pain and emotional regulation. This review examines SP's impact on pain perception and its contributions to MDD, anxiety disorders, and PTSD. The association of SP with increased pain sensitivity and chronic pain conditions underscores its importance in pain modulation. Additionally, SP influences the pathophysiology of MDD, anxiety disorders, and PTSD, highlighting its potential as a therapeutic target. Understanding SP's diverse effects provides valuable insights into the mechanisms underlying these psychiatric disorders and their treatment. Further research is essential to explore SP modulation in psychiatric disorders and develop more effective treatment strategies. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Substance P's Impact on Chronic Pain and Psychiatric Conditions—A Narrative Review.
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  Data: <searchLink fieldCode="AR" term="%22Humes%2C+Charles%22">Humes, Charles</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> charles.humes@my.rfums.org</i><br /><searchLink fieldCode="AR" term="%22Sic%2C+Aleksandar%22">Sic, Aleksandar</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> aca.smed01@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Knezevic%2C+Nebojsa+Nick%22">Knezevic, Nebojsa Nick</searchLink><relatesTo>1,4,5</relatesTo> (AUTHOR)<i> nebojsa.knezevic@aah.org</i>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Molecular+Sciences%22">International Journal of Molecular Sciences</searchLink>. Jun2024, Vol. 25 Issue 11, p5905. 17p.
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  Data: *<searchLink fieldCode="DE" term="%22SUBSTANCE+P%22">SUBSTANCE P</searchLink><br />*<searchLink fieldCode="DE" term="%22CHRONIC+pain%22">CHRONIC pain</searchLink><br />*<searchLink fieldCode="DE" term="%22MENTAL+illness%22">MENTAL illness</searchLink><br />*<searchLink fieldCode="DE" term="%22ANXIETY+disorders%22">ANXIETY disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink>
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  Label: Abstract
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  Data: Substance P (SP) plays a crucial role in pain modulation, with significant implications for major depressive disorder (MDD), anxiety disorders, and post-traumatic stress disorder (PTSD). Elevated SP levels are linked to heightened pain sensitivity and various psychiatric conditions, spurring interest in potential therapeutic interventions. In chronic pain, commonly associated with MDD and anxiety disorders, SP emerges as a key mediator in pain and emotional regulation. This review examines SP's impact on pain perception and its contributions to MDD, anxiety disorders, and PTSD. The association of SP with increased pain sensitivity and chronic pain conditions underscores its importance in pain modulation. Additionally, SP influences the pathophysiology of MDD, anxiety disorders, and PTSD, highlighting its potential as a therapeutic target. Understanding SP's diverse effects provides valuable insights into the mechanisms underlying these psychiatric disorders and their treatment. Further research is essential to explore SP modulation in psychiatric disorders and develop more effective treatment strategies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/ijms25115905
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        Text: English
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      – SubjectFull: SUBSTANCE P
        Type: general
      – SubjectFull: CHRONIC pain
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      – SubjectFull: MENTAL illness
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      – SubjectFull: ANXIETY disorders
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              Text: Jun2024
              Type: published
              Y: 2024
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