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Precise modulation and use of reactive oxygen species for immunotherapy.

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Title: Precise modulation and use of reactive oxygen species for immunotherapy.
Authors: Xinyan Li1,2, Jingjing Gao3,4, Chengcheng Wu1,2, Chaoyu Wang1,2, Ruoshi Zhang1,2, Jia He1,2, Ziting Judy Xia3, Joshi, Nitin3 njoshi@bwh.harvard.edu, Karp, Jeffrey M.3 jmkarp@bwh.harvard.edu, Rui Kuai1,2 ruikuai@tsinghua.edu.cn
Source: Science Advances. 5/17/2024, Vol. 10 Issue 20, p1-17. 17p.
Subject Terms: *IMMUNOTHERAPY, *REACTIVE oxygen species, *BIOMATERIALS, *IMMUNE system, *AUTOIMMUNE diseases, *COMMUNICABLE diseases, *CANCER cells
Abstract: Reactive oxygen species (ROS) play an important role in regulating the immune system by affecting pathogens, cancer cells, and immune cells. Recent advances in biomaterials have leveraged this mechanism to precisely modulate ROS levels in target tissues for improving the effectiveness of immunotherapies in infectious diseases, cancer, and autoimmune diseases. Moreover, ROS-responsive biomaterials can trigger the release of immunotherapeutics and provide tunable release kinetics, which can further boost their efficacy. This review will discuss the latest biomaterial-based approaches for both precise modulation of ROS levels and using ROS as a stimulus to control the release kinetics of immunotherapeutics. Finally, we will discuss the existing challenges and potential solutions for clinical translation of ROS-modulating and ROS-responsive approaches for immunotherapy, and provide an outlook for future research. [ABSTRACT FROM AUTHOR]
Copyright of Science Advances is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Precise modulation and use of reactive oxygen species for immunotherapy.
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  Data: <searchLink fieldCode="AR" term="%22Xinyan+Li%22">Xinyan Li</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jingjing+Gao%22">Jingjing Gao</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Chengcheng+Wu%22">Chengcheng Wu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Chaoyu+Wang%22">Chaoyu Wang</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ruoshi+Zhang%22">Ruoshi Zhang</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jia+He%22">Jia He</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ziting+Judy+Xia%22">Ziting Judy Xia</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Joshi%2C+Nitin%22">Joshi, Nitin</searchLink><relatesTo>3</relatesTo><i> njoshi@bwh.harvard.edu</i><br /><searchLink fieldCode="AR" term="%22Karp%2C+Jeffrey+M%2E%22">Karp, Jeffrey M.</searchLink><relatesTo>3</relatesTo><i> jmkarp@bwh.harvard.edu</i><br /><searchLink fieldCode="AR" term="%22Rui+Kuai%22">Rui Kuai</searchLink><relatesTo>1,2</relatesTo><i> ruikuai@tsinghua.edu.cn</i>
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  Data: Reactive oxygen species (ROS) play an important role in regulating the immune system by affecting pathogens, cancer cells, and immune cells. Recent advances in biomaterials have leveraged this mechanism to precisely modulate ROS levels in target tissues for improving the effectiveness of immunotherapies in infectious diseases, cancer, and autoimmune diseases. Moreover, ROS-responsive biomaterials can trigger the release of immunotherapeutics and provide tunable release kinetics, which can further boost their efficacy. This review will discuss the latest biomaterial-based approaches for both precise modulation of ROS levels and using ROS as a stimulus to control the release kinetics of immunotherapeutics. Finally, we will discuss the existing challenges and potential solutions for clinical translation of ROS-modulating and ROS-responsive approaches for immunotherapy, and provide an outlook for future research. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science Advances is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/sciadv.adl0479
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      – TitleFull: Precise modulation and use of reactive oxygen species for immunotherapy.
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              Text: 5/17/2024
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