Numerous multinucleated giant cells in cutaneous epithelioid angiosarcoma and pulmonary metastasis: A unique observation with potential diagnostic pitfalls.
| Title: | Numerous multinucleated giant cells in cutaneous epithelioid angiosarcoma and pulmonary metastasis: A unique observation with potential diagnostic pitfalls. |
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| Authors: | Kanatani, Yushi1 (AUTHOR), Mitsui, Yasuhiro1,2 (AUTHOR) nagaratenroku@yahoo.co.jp, Ogawa, Kohei1 (AUTHOR), Takeda, Maiko3 (AUTHOR), Miyagawa, Fumi1 (AUTHOR), Shinkuma, Satoru1 (AUTHOR), Kawaguchi, Takeshi4 (AUTHOR), Fukumoto, Takaya5 (AUTHOR), Asada, Hideo1 (AUTHOR) |
| Source: | Journal of Cutaneous Pathology. Jun2024, Vol. 51 Issue 6, p430-433. 4p. |
| Subject Terms: | *MULTINUCLEATED giant cells, *ANGIOSARCOMA, *LUNGS, *SCALP, *METASTASIS, *COMPUTED tomography, *SKIN biopsy |
| Abstract: | The histopathologic diagnosis of poorly differentiated cutaneous angiosarcoma can be challenging. We report a case of cutaneous epithelioid angiosarcoma with numerous multinucleated giant cells (MGCs) developing pulmonary metastasis. A 79‐year‐old man presented with a red–purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2‐40, and ERG. The patient received radiation therapy and chemotherapy, after which a follow‐up CT scan revealed symptomless pneumothorax and pulmonary metastases. The patient received palliative partial lung resection, and the specimen revealed histopathological and immunohistochemical features similar to the primary cutaneous lesion. Our report expands the morphologic spectrum of cutaneous epithelioid angiosarcoma. Cutaneous angiosarcoma is an aggressive neoplasm; thus, awareness of this rare manifestation is important. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Numerous multinucleated giant cells in cutaneous epithelioid angiosarcoma and pulmonary metastasis: A unique observation with potential diagnostic pitfalls. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kanatani%2C+Yushi%22">Kanatani, Yushi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mitsui%2C+Yasuhiro%22">Mitsui, Yasuhiro</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> nagaratenroku@yahoo.co.jp</i><br /><searchLink fieldCode="AR" term="%22Ogawa%2C+Kohei%22">Ogawa, Kohei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takeda%2C+Maiko%22">Takeda, Maiko</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miyagawa%2C+Fumi%22">Miyagawa, Fumi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shinkuma%2C+Satoru%22">Shinkuma, Satoru</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kawaguchi%2C+Takeshi%22">Kawaguchi, Takeshi</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fukumoto%2C+Takaya%22">Fukumoto, Takaya</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asada%2C+Hideo%22">Asada, Hideo</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Cutaneous+Pathology%22">Journal of Cutaneous Pathology</searchLink>. Jun2024, Vol. 51 Issue 6, p430-433. 4p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22MULTINUCLEATED+giant+cells%22">MULTINUCLEATED giant cells</searchLink><br />*<searchLink fieldCode="DE" term="%22ANGIOSARCOMA%22">ANGIOSARCOMA</searchLink><br />*<searchLink fieldCode="DE" term="%22LUNGS%22">LUNGS</searchLink><br />*<searchLink fieldCode="DE" term="%22SCALP%22">SCALP</searchLink><br />*<searchLink fieldCode="DE" term="%22METASTASIS%22">METASTASIS</searchLink><br />*<searchLink fieldCode="DE" term="%22COMPUTED+tomography%22">COMPUTED tomography</searchLink><br />*<searchLink fieldCode="DE" term="%22SKIN+biopsy%22">SKIN biopsy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The histopathologic diagnosis of poorly differentiated cutaneous angiosarcoma can be challenging. We report a case of cutaneous epithelioid angiosarcoma with numerous multinucleated giant cells (MGCs) developing pulmonary metastasis. A 79‐year‐old man presented with a red–purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2‐40, and ERG. The patient received radiation therapy and chemotherapy, after which a follow‐up CT scan revealed symptomless pneumothorax and pulmonary metastases. The patient received palliative partial lung resection, and the specimen revealed histopathological and immunohistochemical features similar to the primary cutaneous lesion. Our report expands the morphologic spectrum of cutaneous epithelioid angiosarcoma. Cutaneous angiosarcoma is an aggressive neoplasm; thus, awareness of this rare manifestation is important. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/cup.14614 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 430 Subjects: – SubjectFull: MULTINUCLEATED giant cells Type: general – SubjectFull: ANGIOSARCOMA Type: general – SubjectFull: LUNGS Type: general – SubjectFull: SCALP Type: general – SubjectFull: METASTASIS Type: general – SubjectFull: COMPUTED tomography Type: general – SubjectFull: SKIN biopsy Type: general Titles: – TitleFull: Numerous multinucleated giant cells in cutaneous epithelioid angiosarcoma and pulmonary metastasis: A unique observation with potential diagnostic pitfalls. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kanatani, Yushi – PersonEntity: Name: NameFull: Mitsui, Yasuhiro – PersonEntity: Name: NameFull: Ogawa, Kohei – PersonEntity: Name: NameFull: Takeda, Maiko – PersonEntity: Name: NameFull: Miyagawa, Fumi – PersonEntity: Name: NameFull: Shinkuma, Satoru – PersonEntity: Name: NameFull: Kawaguchi, Takeshi – PersonEntity: Name: NameFull: Fukumoto, Takaya – PersonEntity: Name: NameFull: Asada, Hideo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 03036987 Numbering: – Type: volume Value: 51 – Type: issue Value: 6 Titles: – TitleFull: Journal of Cutaneous Pathology Type: main |
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