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ADAMTS-13: A Prognostic Biomarker for Portal Vein Thrombosis in Japanese Patients with Liver Cirrhosis.

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Title: ADAMTS-13: A Prognostic Biomarker for Portal Vein Thrombosis in Japanese Patients with Liver Cirrhosis.
Authors: Suzuki, Junya1 (AUTHOR) suzukij@naramed-u.ac.jp, Namisaki, Tadashi1 (AUTHOR) htky@naramed-u.ac.jp, Takya, Hiroaki1 (AUTHOR) kajik@naramed-u.ac.jp, Kaji, Kosuke1 (AUTHOR) a-shibamoto@naramed-u.ac.jp, Nishimura, Norihisa1 (AUTHOR) asahei@naramed-u.ac.jp, Shibamoto, Akihiko1 (AUTHOR) kubotaka@naramed-u.ac.jp, Asada, Shohei1 (AUTHOR) satoshi181@naramed-u.ac.jp, Kubo, Takahiro1 (AUTHOR) tomooka@naramed-u.ac.jp, Iwai, Satoshi1 (AUTHOR) souitit@naramed-u.ac.jp, Tomooka, Fumimasa1 (AUTHOR) yuring0309@naramed-u.ac.jp, Takeda, Soichi1 (AUTHOR) mtanaka@naramed-u.ac.jp, Koizumi, Aritoshi1 (AUTHOR) takuya@naramed-u.ac.jp, Tanaka, Misako1 (AUTHOR) yukifuji@naramed-u.ac.jp, Matsuda, Takuya1 (AUTHOR) tsujih@naramed-u.ac.jp, Inoue, Takashi2 (AUTHOR) tkinoue0@naramed-u.ac.jp, Fujimoto, Yuki1 (AUTHOR) fujinaga@naramed-u.ac.jp, Tsuji, Yuki1 (AUTHOR) shinyasato@naramed-u.ac.jp, Fujinaga, Yukihisa1 (AUTHOR) kawara@naramed-u.ac.jp, Sato, Shinya1 (AUTHOR) stakemi@naramed-u.ac.jp, Kitagawa, Koh1 (AUTHOR) mitoroak@naramed-u.ac.jp
Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2678. 13p.
Subject Terms: *PORTAL vein, *JAPANESE people, *SPIRAL computed tomography, *CIRRHOSIS of the liver, *FIBRIN fibrinogen degradation products, *FIBRIN
Abstract: Portal vein thrombosis (PVT), one of the most prevalent hepatic vascular conditions in patients with liver cirrhosis (LC), is associated with high mortality rates. An imbalance between a disintegrin-like metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS-13) enzyme and von Willebrand factor (VWF) is responsible for hypercoagulability, including spontaneous thrombus formation in blood vessels. Herein, we aimed to identify potential prognostic and diagnostic biomarkers in Japanese patients with LC and PVT. In total, 345 patients were divided into two groups: 40 patients who developed PVT (PVT group) and 305 who did not develop PVT (NPVT group). Among the 345 patients with LC, 81% (279/345) were deemed ineligible due to the presence of preventive comorbidities, active or recent malignancies, and organ dysfunction. The remaining 66 patients were divided into two groups: the PVT group (n = 33) and the NPVT group (n = 33). Plasma ADAMTS-13 activity (ADAMTS-13:AC) and the vWF antigen (VWF:Ag) were measured using enzyme-linked immunosorbent assays. Contrast-enhanced, three-dimensional helical computed tomography (CT) was used to detect and characterize PVT. ADAMTS-13:AC was significantly lower in the PVT group than in the NPVT group. No significant differences in plasma vWF:Ag or liver stiffness were observed between the two groups. ADAMTS-13:AC of <18.8 was an independent risk factor for PVT on multivariate analyses (odds ratio: 1.67, 95% confidence interval: 1.21–3.00, p < 0.002). The receiver operating characteristic analysis of ADAMTS-13:AC revealed an area under the curve of 0.913 in PVT detection. Patients with PVT having ADAMTS-13:AC ≥18.8 (n = 17) had higher albumin levels and better prognoses than those with ADAMTS-13:AC <18.8 (n = 16). No significant correlations of ADAMTS-13:AC levels with either fibrin degradation product or D-dimer levels were observed. ADAMTS-13:AC levels could be potential diagnostic and prognostic biomarkers for PVT in Japanese patients with LC. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: ADAMTS-13: A Prognostic Biomarker for Portal Vein Thrombosis in Japanese Patients with Liver Cirrhosis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Suzuki%2C+Junya%22&quot;&gt;Suzuki, Junya&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; suzukij@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Namisaki%2C+Tadashi%22&quot;&gt;Namisaki, Tadashi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; htky@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Takya%2C+Hiroaki%22&quot;&gt;Takya, Hiroaki&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; kajik@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kaji%2C+Kosuke%22&quot;&gt;Kaji, Kosuke&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; a-shibamoto@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nishimura%2C+Norihisa%22&quot;&gt;Nishimura, Norihisa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; asahei@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shibamoto%2C+Akihiko%22&quot;&gt;Shibamoto, Akihiko&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; kubotaka@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Asada%2C+Shohei%22&quot;&gt;Asada, Shohei&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; satoshi181@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kubo%2C+Takahiro%22&quot;&gt;Kubo, Takahiro&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; tomooka@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Iwai%2C+Satoshi%22&quot;&gt;Iwai, Satoshi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; souitit@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tomooka%2C+Fumimasa%22&quot;&gt;Tomooka, Fumimasa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; yuring0309@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Takeda%2C+Soichi%22&quot;&gt;Takeda, Soichi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; mtanaka@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Koizumi%2C+Aritoshi%22&quot;&gt;Koizumi, Aritoshi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; takuya@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tanaka%2C+Misako%22&quot;&gt;Tanaka, Misako&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; yukifuji@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Matsuda%2C+Takuya%22&quot;&gt;Matsuda, Takuya&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; tsujih@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Inoue%2C+Takashi%22&quot;&gt;Inoue, Takashi&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; tkinoue0@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fujimoto%2C+Yuki%22&quot;&gt;Fujimoto, Yuki&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; fujinaga@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tsuji%2C+Yuki%22&quot;&gt;Tsuji, Yuki&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; shinyasato@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fujinaga%2C+Yukihisa%22&quot;&gt;Fujinaga, Yukihisa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; kawara@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sato%2C+Shinya%22&quot;&gt;Sato, Shinya&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; stakemi@naramed-u.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kitagawa%2C+Koh%22&quot;&gt;Kitagawa, Koh&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; mitoroak@naramed-u.ac.jp&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Molecular+Sciences%22&quot;&gt;International Journal of Molecular Sciences&lt;/searchLink&gt;. Mar2024, Vol. 25 Issue 5, p2678. 13p.
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  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PORTAL+vein%22&quot;&gt;PORTAL vein&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22JAPANESE+people%22&quot;&gt;JAPANESE people&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SPIRAL+computed+tomography%22&quot;&gt;SPIRAL computed tomography&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CIRRHOSIS+of+the+liver%22&quot;&gt;CIRRHOSIS of the liver&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22FIBRIN+fibrinogen+degradation+products%22&quot;&gt;FIBRIN fibrinogen degradation products&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22FIBRIN%22&quot;&gt;FIBRIN&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Portal vein thrombosis (PVT), one of the most prevalent hepatic vascular conditions in patients with liver cirrhosis (LC), is associated with high mortality rates. An imbalance between a disintegrin-like metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS-13) enzyme and von Willebrand factor (VWF) is responsible for hypercoagulability, including spontaneous thrombus formation in blood vessels. Herein, we aimed to identify potential prognostic and diagnostic biomarkers in Japanese patients with LC and PVT. In total, 345 patients were divided into two groups: 40 patients who developed PVT (PVT group) and 305 who did not develop PVT (NPVT group). Among the 345 patients with LC, 81% (279/345) were deemed ineligible due to the presence of preventive comorbidities, active or recent malignancies, and organ dysfunction. The remaining 66 patients were divided into two groups: the PVT group (n = 33) and the NPVT group (n = 33). Plasma ADAMTS-13 activity (ADAMTS-13:AC) and the vWF antigen (VWF:Ag) were measured using enzyme-linked immunosorbent assays. Contrast-enhanced, three-dimensional helical computed tomography (CT) was used to detect and characterize PVT. ADAMTS-13:AC was significantly lower in the PVT group than in the NPVT group. No significant differences in plasma vWF:Ag or liver stiffness were observed between the two groups. ADAMTS-13:AC of &lt;18.8 was an independent risk factor for PVT on multivariate analyses (odds ratio: 1.67, 95% confidence interval: 1.21–3.00, p &lt; 0.002). The receiver operating characteristic analysis of ADAMTS-13:AC revealed an area under the curve of 0.913 in PVT detection. Patients with PVT having ADAMTS-13:AC ≥18.8 (n = 17) had higher albumin levels and better prognoses than those with ADAMTS-13:AC &lt;18.8 (n = 16). No significant correlations of ADAMTS-13:AC levels with either fibrin degradation product or D-dimer levels were observed. ADAMTS-13:AC levels could be potential diagnostic and prognostic biomarkers for PVT in Japanese patients with LC. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.3390/ijms25052678
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
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        PageCount: 13
        StartPage: 2678
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      – SubjectFull: PORTAL vein
        Type: general
      – SubjectFull: JAPANESE people
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      – SubjectFull: SPIRAL computed tomography
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      – SubjectFull: CIRRHOSIS of the liver
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      – SubjectFull: FIBRIN fibrinogen degradation products
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      – SubjectFull: FIBRIN
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      – TitleFull: ADAMTS-13: A Prognostic Biomarker for Portal Vein Thrombosis in Japanese Patients with Liver Cirrhosis.
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              Text: Mar2024
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