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Digital light processing bio-scaffolds of hydroxyapatite ceramic foams with multi-level pores using Pickering emulsions as the feedstock.

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Title: Digital light processing bio-scaffolds of hydroxyapatite ceramic foams with multi-level pores using Pickering emulsions as the feedstock.
Authors: Guo, Jingjing1 (AUTHOR), Zhang, Xiaoyan1,2 (AUTHOR) xiaoyanzhang666@163.com, Yan, Jinfeng3 (AUTHOR), Wu, Jiamin3 (AUTHOR), Shi, Yusheng3 (AUTHOR), Zhang, Shengen1 (AUTHOR) zhangshengen@mater.ustb.edu.cn
Source: Journal of the European Ceramic Society. Jun2024, Vol. 44 Issue 6, p4272-4284. 13p.
Subject Terms: *BIOACTIVE glasses, *CO-cultures, *MECHANICAL behavior of materials, *PORE size distribution, *EMULSIONS, *HYDROXYAPATITE, *FOAM, *CERAMICS
Abstract: To prepare bio-scaffolds with multi-stage pores, excellent mechanical and biological properties to meet the requirements of personalized bone repair, digital light processing using Pickering emulsion as paste has been proposed here firstly for porous hydroxyapatite scaffolds with complex shape and fine microstructure. It is found that dispersant content, solid loading and oil to water ratio of Pickering emulsions play vital roles on the controlling of pore morphology and pore size distribution of final hydroxyapatite ceramic foams. The multi-stage pores consist of millimeter-scale pores designed by 3D models and micro-pores below 10 µm derived from emulsion droplets. Due to the integration of hierarchical pores at different scale levels and micropores, hydroxyapatite ceramic foams possess outstanding compressive strength of 4.46–8.03 MPa at porosity of 76.59-72.96%. In vitro cell experiments illustrate that rat bone mesenchymal stem cells can spread and adhere to bio-scaffolds, promoting cell proliferation effectively and further verifying their good biocompatibility. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the European Ceramic Society is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Digital light processing bio-scaffolds of hydroxyapatite ceramic foams with multi-level pores using Pickering emulsions as the feedstock.
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  Data: <searchLink fieldCode="AR" term="%22Guo%2C+Jingjing%22">Guo, Jingjing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoyan%22">Zhang, Xiaoyan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> xiaoyanzhang666@163.com</i><br /><searchLink fieldCode="AR" term="%22Yan%2C+Jinfeng%22">Yan, Jinfeng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Jiamin%22">Wu, Jiamin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Yusheng%22">Shi, Yusheng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Shengen%22">Zhang, Shengen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zhangshengen@mater.ustb.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+European+Ceramic+Society%22">Journal of the European Ceramic Society</searchLink>. Jun2024, Vol. 44 Issue 6, p4272-4284. 13p.
– Name: Subject
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  Data: *<searchLink fieldCode="DE" term="%22BIOACTIVE+glasses%22">BIOACTIVE glasses</searchLink><br />*<searchLink fieldCode="DE" term="%22CO-cultures%22">CO-cultures</searchLink><br />*<searchLink fieldCode="DE" term="%22MECHANICAL+behavior+of+materials%22">MECHANICAL behavior of materials</searchLink><br />*<searchLink fieldCode="DE" term="%22PORE+size+distribution%22">PORE size distribution</searchLink><br />*<searchLink fieldCode="DE" term="%22EMULSIONS%22">EMULSIONS</searchLink><br />*<searchLink fieldCode="DE" term="%22HYDROXYAPATITE%22">HYDROXYAPATITE</searchLink><br />*<searchLink fieldCode="DE" term="%22FOAM%22">FOAM</searchLink><br />*<searchLink fieldCode="DE" term="%22CERAMICS%22">CERAMICS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: To prepare bio-scaffolds with multi-stage pores, excellent mechanical and biological properties to meet the requirements of personalized bone repair, digital light processing using Pickering emulsion as paste has been proposed here firstly for porous hydroxyapatite scaffolds with complex shape and fine microstructure. It is found that dispersant content, solid loading and oil to water ratio of Pickering emulsions play vital roles on the controlling of pore morphology and pore size distribution of final hydroxyapatite ceramic foams. The multi-stage pores consist of millimeter-scale pores designed by 3D models and micro-pores below 10 µm derived from emulsion droplets. Due to the integration of hierarchical pores at different scale levels and micropores, hydroxyapatite ceramic foams possess outstanding compressive strength of 4.46–8.03 MPa at porosity of 76.59-72.96%. In vitro cell experiments illustrate that rat bone mesenchymal stem cells can spread and adhere to bio-scaffolds, promoting cell proliferation effectively and further verifying their good biocompatibility. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the European Ceramic Society is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.jeurceramsoc.2024.01.021
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 4272
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      – SubjectFull: BIOACTIVE glasses
        Type: general
      – SubjectFull: CO-cultures
        Type: general
      – SubjectFull: MECHANICAL behavior of materials
        Type: general
      – SubjectFull: PORE size distribution
        Type: general
      – SubjectFull: EMULSIONS
        Type: general
      – SubjectFull: HYDROXYAPATITE
        Type: general
      – SubjectFull: FOAM
        Type: general
      – SubjectFull: CERAMICS
        Type: general
    Titles:
      – TitleFull: Digital light processing bio-scaffolds of hydroxyapatite ceramic foams with multi-level pores using Pickering emulsions as the feedstock.
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          Name:
            NameFull: Guo, Jingjing
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            NameFull: Zhang, Xiaoyan
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            NameFull: Yan, Jinfeng
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            NameFull: Wu, Jiamin
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            NameFull: Shi, Yusheng
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            NameFull: Zhang, Shengen
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            – D: 01
              M: 06
              Text: Jun2024
              Type: published
              Y: 2024
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              Value: 44
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              Value: 6
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            – TitleFull: Journal of the European Ceramic Society
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