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Quantitative Colorimetric Sensing of Carbidopa in Anti-Parkinson Drugs Based on Selective Reaction with Indole-3-Carbaldehyde.

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Title: Quantitative Colorimetric Sensing of Carbidopa in Anti-Parkinson Drugs Based on Selective Reaction with Indole-3-Carbaldehyde.
Authors: Palladino, Pasquale1 (AUTHOR) pasquale.palladino@unifi.it, Rainetti, Alberto1 (AUTHOR), Lettieri, Mariagrazia2 (AUTHOR), Pieraccini, Giuseppe3 (AUTHOR), Scarano, Simona1 (AUTHOR), Minunni, Maria4 (AUTHOR)
Source: Sensors (14248220). Nov2023, Vol. 23 Issue 22, p9142. 12p.
Subject Terms: *CARBIDOPA, *DOPA, *PARKINSON'S disease, *DRUG standards, *CONDENSATION reactions, *FUNCTIONAL groups, *QUALITY control
Abstract: The quality of life of patients affected by Parkinson's disease is improved by medications containing levodopa and carbidopa, restoring the dopamine concentration in the brain. Accordingly, the affordable quality control of such pharmaceuticals is very important. Here is reported the simple and inexpensive colorimetric quantification of carbidopa in anti-Parkinson drugs by the selective condensation reaction between the hydrazine group from carbidopa and the formyl functional group of selected aldehydes in acidified hydroalcoholic solution. An optical assay was developed by using indole-3-carbaldehyde (I3A) giving a yellow aldazine in EtOH:H2O 1:1 (λmax~415 nm) at 70 °C for 4 h, as confirmed by LC-MS analysis. A filter-based plate reader was used for colorimetric data acquisition, providing superior results in terms of analytical performances for I3A, with a sensitivity ~50 L g−1 and LOD ~0.1 mg L−1 in comparison to a previous study based on vanillin, giving, for the same figures of merit values, about 13 L g−1 and 0.2–0.3 mg L−1, respectively. The calibration curves for the standard solution and drugs were almost superimposable, therefore excluding interference from the excipients and additives, with very good reproducibility (avRSD% 2–4%) within the linear dynamic range (10 mg L−1–50 mg L−1). [ABSTRACT FROM AUTHOR]
Copyright of Sensors (14248220) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Quantitative Colorimetric Sensing of Carbidopa in Anti-Parkinson Drugs Based on Selective Reaction with Indole-3-Carbaldehyde.
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  Data: <searchLink fieldCode="JN" term="%22Sensors+%2814248220%29%22">Sensors (14248220)</searchLink>. Nov2023, Vol. 23 Issue 22, p9142. 12p.
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  Data: *<searchLink fieldCode="DE" term="%22CARBIDOPA%22">CARBIDOPA</searchLink><br />*<searchLink fieldCode="DE" term="%22DOPA%22">DOPA</searchLink><br />*<searchLink fieldCode="DE" term="%22PARKINSON'S+disease%22">PARKINSON'S disease</searchLink><br />*<searchLink fieldCode="DE" term="%22DRUG+standards%22">DRUG standards</searchLink><br />*<searchLink fieldCode="DE" term="%22CONDENSATION+reactions%22">CONDENSATION reactions</searchLink><br />*<searchLink fieldCode="DE" term="%22FUNCTIONAL+groups%22">FUNCTIONAL groups</searchLink><br />*<searchLink fieldCode="DE" term="%22QUALITY+control%22">QUALITY control</searchLink>
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  Data: The quality of life of patients affected by Parkinson's disease is improved by medications containing levodopa and carbidopa, restoring the dopamine concentration in the brain. Accordingly, the affordable quality control of such pharmaceuticals is very important. Here is reported the simple and inexpensive colorimetric quantification of carbidopa in anti-Parkinson drugs by the selective condensation reaction between the hydrazine group from carbidopa and the formyl functional group of selected aldehydes in acidified hydroalcoholic solution. An optical assay was developed by using indole-3-carbaldehyde (I3A) giving a yellow aldazine in EtOH:H2O 1:1 (λmax~415 nm) at 70 °C for 4 h, as confirmed by LC-MS analysis. A filter-based plate reader was used for colorimetric data acquisition, providing superior results in terms of analytical performances for I3A, with a sensitivity ~50 L g−1 and LOD ~0.1 mg L−1 in comparison to a previous study based on vanillin, giving, for the same figures of merit values, about 13 L g−1 and 0.2–0.3 mg L−1, respectively. The calibration curves for the standard solution and drugs were almost superimposable, therefore excluding interference from the excipients and additives, with very good reproducibility (avRSD% 2–4%) within the linear dynamic range (10 mg L−1–50 mg L−1). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Sensors (14248220) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/s23229142
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        Text: English
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      – SubjectFull: DOPA
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      – SubjectFull: PARKINSON'S disease
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      – SubjectFull: QUALITY control
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      – TitleFull: Quantitative Colorimetric Sensing of Carbidopa in Anti-Parkinson Drugs Based on Selective Reaction with Indole-3-Carbaldehyde.
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              Text: Nov2023
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