A comparative study of intrathecal levobupivacaine-clonidine and bupivacaine in the quality of anesthesia for patients undergoing hernioplasty.
| Title: | A comparative study of intrathecal levobupivacaine-clonidine and bupivacaine in the quality of anesthesia for patients undergoing hernioplasty. |
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| Authors: | Dutta, Sayantan1, Das, Sushmita1, Saha, Debasish2, Nayak, Jisnu3 nayakjisnu@gmail.com |
| Source: | Asian Journal of Medical Sciences. Oct2023, Vol. 14 Issue 10, p61-66. 6p. |
| Subject Terms: | *BUPIVACAINE, *ADRENERGIC agonists, *BRACHIAL plexus block, *LOCAL anesthetics, *ANESTHESIA, *SURGICAL complications |
| Abstract: | Background: Bupivacaine is most commonly used amino-amide drug for subarachnoid block in hernioplasty. Levobupivacaine has similar pharmacological activity to that of bupivacaine with minimal cardiotoxicity. Clonidine, an a2 adrenergic agonist, potentiates the action of local anesthetics when used intrathecally and enhances post-operative analgesia. Aims and Objectives: This prospective, comparative, observational study was aimed to compare the effects of 0.5% levobupivacaine with clonidine and 0.5% hyperbaric bupivacaine in patients undergoing hernioplasty for the quality of surgical anesthesia and hemodynamic changes with any significant intraoperative complications. Materials and Methods: After receiving approval from the institutional ethics committee and written informed consent, 80 male patients aged between 18 and 60 years, BMI <30 kg/m2, height>150 cm, and American society of anesthesiologists physical status1 and 2 posted for elective hernioplasty were enrolled into two equal groups of 40 patients, group LC and group B. Patients in group LC received 15 mg 0.5% isobaric levobupivacaine with 30 µg clonidine and patients in group B received 15 mg hyperbaric bupivacaine intrathecally. SPSS version 20 was used for analysis, and P<0.05 was considered statistically significant. Results: In group LC, onsets of both sensory and motor blocks were delayed, whereas durations of motor and sensory block with analgesia were longer. Tachycardia, hypotension, nausea, vomiting, and shivering were observed greater in numbers in group B, whereas incidence of bradycardia was more in group LC. Conclusion: Prolonged duration of sensory and motor block, prolonged analgesic effect, and hemodynamic stability without any significant adverse effects may make this combination a better alternative to hyperbaric bupivacaine for hernioplasty. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: A comparative study of intrathecal levobupivacaine-clonidine and bupivacaine in the quality of anesthesia for patients undergoing hernioplasty. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dutta%2C+Sayantan%22">Dutta, Sayantan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Das%2C+Sushmita%22">Das, Sushmita</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Saha%2C+Debasish%22">Saha, Debasish</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Nayak%2C+Jisnu%22">Nayak, Jisnu</searchLink><relatesTo>3</relatesTo><i> nayakjisnu@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Asian+Journal+of+Medical+Sciences%22">Asian Journal of Medical Sciences</searchLink>. Oct2023, Vol. 14 Issue 10, p61-66. 6p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22BUPIVACAINE%22">BUPIVACAINE</searchLink><br />*<searchLink fieldCode="DE" term="%22ADRENERGIC+agonists%22">ADRENERGIC agonists</searchLink><br />*<searchLink fieldCode="DE" term="%22BRACHIAL+plexus+block%22">BRACHIAL plexus block</searchLink><br />*<searchLink fieldCode="DE" term="%22LOCAL+anesthetics%22">LOCAL anesthetics</searchLink><br />*<searchLink fieldCode="DE" term="%22ANESTHESIA%22">ANESTHESIA</searchLink><br />*<searchLink fieldCode="DE" term="%22SURGICAL+complications%22">SURGICAL complications</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Bupivacaine is most commonly used amino-amide drug for subarachnoid block in hernioplasty. Levobupivacaine has similar pharmacological activity to that of bupivacaine with minimal cardiotoxicity. Clonidine, an a2 adrenergic agonist, potentiates the action of local anesthetics when used intrathecally and enhances post-operative analgesia. Aims and Objectives: This prospective, comparative, observational study was aimed to compare the effects of 0.5% levobupivacaine with clonidine and 0.5% hyperbaric bupivacaine in patients undergoing hernioplasty for the quality of surgical anesthesia and hemodynamic changes with any significant intraoperative complications. Materials and Methods: After receiving approval from the institutional ethics committee and written informed consent, 80 male patients aged between 18 and 60 years, BMI <30 kg/m2, height>150 cm, and American society of anesthesiologists physical status1 and 2 posted for elective hernioplasty were enrolled into two equal groups of 40 patients, group LC and group B. Patients in group LC received 15 mg 0.5% isobaric levobupivacaine with 30 µg clonidine and patients in group B received 15 mg hyperbaric bupivacaine intrathecally. SPSS version 20 was used for analysis, and P<0.05 was considered statistically significant. Results: In group LC, onsets of both sensory and motor blocks were delayed, whereas durations of motor and sensory block with analgesia were longer. Tachycardia, hypotension, nausea, vomiting, and shivering were observed greater in numbers in group B, whereas incidence of bradycardia was more in group LC. Conclusion: Prolonged duration of sensory and motor block, prolonged analgesic effect, and hemodynamic stability without any significant adverse effects may make this combination a better alternative to hyperbaric bupivacaine for hernioplasty. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Asian Journal of Medical Sciences is the property of Manipal Colleges of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3126/ajms.v14i10.53369 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 61 Subjects: – SubjectFull: BUPIVACAINE Type: general – SubjectFull: ADRENERGIC agonists Type: general – SubjectFull: BRACHIAL plexus block Type: general – SubjectFull: LOCAL anesthetics Type: general – SubjectFull: ANESTHESIA Type: general – SubjectFull: SURGICAL complications Type: general Titles: – TitleFull: A comparative study of intrathecal levobupivacaine-clonidine and bupivacaine in the quality of anesthesia for patients undergoing hernioplasty. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dutta, Sayantan – PersonEntity: Name: NameFull: Das, Sushmita – PersonEntity: Name: NameFull: Saha, Debasish – PersonEntity: Name: NameFull: Nayak, Jisnu IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 24679100 Numbering: – Type: volume Value: 14 – Type: issue Value: 10 Titles: – TitleFull: Asian Journal of Medical Sciences Type: main |
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