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Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty.

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Title: Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty.
Authors: Er, Eren1 drerener1984@gmail.com, Ata, Aysun2, Orgun, Ali3
Source: Journal of Pediatric Research. Sep2023, Vol. 10 Issue 3, p222-227. 6p.
Subject Terms: *PRECOCIOUS puberty, *LEUPROLIDE, *CARDIOVASCULAR diseases, *LONG QT syndrome, *GONADOTROPIN releasing hormone, *COMPARATIVE studies, *ELECTROCARDIOGRAPHY, *ACETIC acid, *HEART beat, *LONGITUDINAL method, *CHEMICAL inhibitors
Abstract: Aim: Gonadotropin-releasing hormone analogs (GnRHa) are standard medical treatments for precocious puberty. Studies on their side effects in adults have shown that these drugs can cause changes in electrocardiography (ECG), along with some cardiovascular effects; however, the number of studies on children is limited. This study investigated the effects of these drugs on ECG parameters in children diagnosed with central precocious puberty (CPP). Materials and Methods: This prospective study included 44 girls who were initiated GnRHa treatment and diagnosed with CPP. ECG was performed before treatment and repeated after 6 months of treatment. Results: The mean age of the children was 9.13±1.55 years. Leuprolide acetate (3.75 mg IM) was administered to all of the patients following the standard protocol. A comparison of the pre-treatment and 6-month ECG parameters revealed a prolonged QT interval after treatment, with a statistically significant difference (p<0.001). There were no significant differences in the pre- and post-treatment values of PR, QRS, QT interval, QTc interval, QT dispersion, or QTc dispersion (p>0.05). Conclusion: Despite a significant increase in QT interval on ECG with GnRHa compared to pre-treatment ECGs, this increase was attributed to a variability in heart rate. Even if regular ECG monitoring is considered after initiation of GnRHa treatment, they are believed to be safe drugs in children. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Pediatric Research is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Er%2C+Eren%22&quot;&gt;Er, Eren&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; drerener1984@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ata%2C+Aysun%22&quot;&gt;Ata, Aysun&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Orgun%2C+Ali%22&quot;&gt;Orgun, Ali&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Pediatric+Research%22&quot;&gt;Journal of Pediatric Research&lt;/searchLink&gt;. Sep2023, Vol. 10 Issue 3, p222-227. 6p.
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  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PRECOCIOUS+puberty%22&quot;&gt;PRECOCIOUS puberty&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22LEUPROLIDE%22&quot;&gt;LEUPROLIDE&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CARDIOVASCULAR+diseases%22&quot;&gt;CARDIOVASCULAR diseases&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22LONG+QT+syndrome%22&quot;&gt;LONG QT syndrome&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22GONADOTROPIN+releasing+hormone%22&quot;&gt;GONADOTROPIN releasing hormone&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22COMPARATIVE+studies%22&quot;&gt;COMPARATIVE studies&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ELECTROCARDIOGRAPHY%22&quot;&gt;ELECTROCARDIOGRAPHY&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ACETIC+acid%22&quot;&gt;ACETIC acid&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HEART+beat%22&quot;&gt;HEART beat&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22LONGITUDINAL+method%22&quot;&gt;LONGITUDINAL method&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CHEMICAL+inhibitors%22&quot;&gt;CHEMICAL inhibitors&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: Gonadotropin-releasing hormone analogs (GnRHa) are standard medical treatments for precocious puberty. Studies on their side effects in adults have shown that these drugs can cause changes in electrocardiography (ECG), along with some cardiovascular effects; however, the number of studies on children is limited. This study investigated the effects of these drugs on ECG parameters in children diagnosed with central precocious puberty (CPP). Materials and Methods: This prospective study included 44 girls who were initiated GnRHa treatment and diagnosed with CPP. ECG was performed before treatment and repeated after 6 months of treatment. Results: The mean age of the children was 9.13&#177;1.55 years. Leuprolide acetate (3.75 mg IM) was administered to all of the patients following the standard protocol. A comparison of the pre-treatment and 6-month ECG parameters revealed a prolonged QT interval after treatment, with a statistically significant difference (p&lt;0.001). There were no significant differences in the pre- and post-treatment values of PR, QRS, QT interval, QTc interval, QT dispersion, or QTc dispersion (p&gt;0.05). Conclusion: Despite a significant increase in QT interval on ECG with GnRHa compared to pre-treatment ECGs, this increase was attributed to a variability in heart rate. Even if regular ECG monitoring is considered after initiation of GnRHa treatment, they are believed to be safe drugs in children. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Pediatric Research is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.4274/jpr.galenos.2023.48753
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 222
    Subjects:
      – SubjectFull: PRECOCIOUS puberty
        Type: general
      – SubjectFull: LEUPROLIDE
        Type: general
      – SubjectFull: CARDIOVASCULAR diseases
        Type: general
      – SubjectFull: LONG QT syndrome
        Type: general
      – SubjectFull: GONADOTROPIN releasing hormone
        Type: general
      – SubjectFull: COMPARATIVE studies
        Type: general
      – SubjectFull: ELECTROCARDIOGRAPHY
        Type: general
      – SubjectFull: ACETIC acid
        Type: general
      – SubjectFull: HEART beat
        Type: general
      – SubjectFull: LONGITUDINAL method
        Type: general
      – SubjectFull: CHEMICAL inhibitors
        Type: general
    Titles:
      – TitleFull: Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Precocious Puberty.
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          Name:
            NameFull: Er, Eren
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          Name:
            NameFull: Ata, Aysun
      – PersonEntity:
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            NameFull: Orgun, Ali
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            – D: 01
              M: 09
              Text: Sep2023
              Type: published
              Y: 2023
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              Value: 10
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              Value: 3
          Titles:
            – TitleFull: Journal of Pediatric Research
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