Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues.
| Title: | Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues. |
|---|---|
| Authors: | Vasconcelos, Carlos Franciney Moreira1,2 (AUTHOR) cfmvasconcelos@biof.ufrj.br, Ribas, Vinicius Toledo3 (AUTHOR) ribasvt@ufmg.br, Petrs-Silva, Hilda2 (AUTHOR) cfmvasconcelos@biof.ufrj.br |
| Source: | Cells (2073-4409). Sep2023, Vol. 12 Issue 17, p2155. 19p. |
| Subject Terms: | *RNA regulation, *NEURODEGENERATION, *ALZHEIMER'S disease, *HUNTINGTON disease, *PARKINSON'S disease, *AMYOTROPHIC lateral sclerosis, *MOTOR neuron diseases |
| Abstract: | Advances in RNA-sequencing technologies have led to the identification of molecular biomarkers for several diseases, including neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's diseases and Amyotrophic Lateral Sclerosis. Despite the nature of glaucoma as a neurodegenerative disorder with several similarities with the other above-mentioned diseases, transcriptional data about this disease are still scarce. microRNAs are small molecules (~17–25 nucleotides) that have been found to be specifically expressed in the CNS as major components of the system regulating the development signatures of neurodegenerative diseases and the homeostasis of the brain. In this review, we sought to identify similarities between the functional mechanisms and the activated pathways of the most common neurodegenerative diseases, as well as to discuss how those mechanisms are regulated by miRNAs, using RNA-Seq as an approach to compare them. We also discuss therapeutically suitable applications for these disease hallmarks in clinical future studies. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vasconcelos%2C+Carlos+Franciney+Moreira%22">Vasconcelos, Carlos Franciney Moreira</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> cfmvasconcelos@biof.ufrj.br</i><br /><searchLink fieldCode="AR" term="%22Ribas%2C+Vinicius+Toledo%22">Ribas, Vinicius Toledo</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> ribasvt@ufmg.br</i><br /><searchLink fieldCode="AR" term="%22Petrs-Silva%2C+Hilda%22">Petrs-Silva, Hilda</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> cfmvasconcelos@biof.ufrj.br</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Cells+%282073-4409%29%22">Cells (2073-4409)</searchLink>. Sep2023, Vol. 12 Issue 17, p2155. 19p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22RNA+regulation%22">RNA regulation</searchLink><br />*<searchLink fieldCode="DE" term="%22NEURODEGENERATION%22">NEURODEGENERATION</searchLink><br />*<searchLink fieldCode="DE" term="%22ALZHEIMER'S+disease%22">ALZHEIMER'S disease</searchLink><br />*<searchLink fieldCode="DE" term="%22HUNTINGTON+disease%22">HUNTINGTON disease</searchLink><br />*<searchLink fieldCode="DE" term="%22PARKINSON'S+disease%22">PARKINSON'S disease</searchLink><br />*<searchLink fieldCode="DE" term="%22AMYOTROPHIC+lateral+sclerosis%22">AMYOTROPHIC lateral sclerosis</searchLink><br />*<searchLink fieldCode="DE" term="%22MOTOR+neuron+diseases%22">MOTOR neuron diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Advances in RNA-sequencing technologies have led to the identification of molecular biomarkers for several diseases, including neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's diseases and Amyotrophic Lateral Sclerosis. Despite the nature of glaucoma as a neurodegenerative disorder with several similarities with the other above-mentioned diseases, transcriptional data about this disease are still scarce. microRNAs are small molecules (~17–25 nucleotides) that have been found to be specifically expressed in the CNS as major components of the system regulating the development signatures of neurodegenerative diseases and the homeostasis of the brain. In this review, we sought to identify similarities between the functional mechanisms and the activated pathways of the most common neurodegenerative diseases, as well as to discuss how those mechanisms are regulated by miRNAs, using RNA-Seq as an approach to compare them. We also discuss therapeutically suitable applications for these disease hallmarks in clinical future studies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/cells12172155 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 2155 Subjects: – SubjectFull: RNA regulation Type: general – SubjectFull: NEURODEGENERATION Type: general – SubjectFull: ALZHEIMER'S disease Type: general – SubjectFull: HUNTINGTON disease Type: general – SubjectFull: PARKINSON'S disease Type: general – SubjectFull: AMYOTROPHIC lateral sclerosis Type: general – SubjectFull: MOTOR neuron diseases Type: general Titles: – TitleFull: Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vasconcelos, Carlos Franciney Moreira – PersonEntity: Name: NameFull: Ribas, Vinicius Toledo – PersonEntity: Name: NameFull: Petrs-Silva, Hilda IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20734409 Numbering: – Type: volume Value: 12 – Type: issue Value: 17 Titles: – TitleFull: Cells (2073-4409) Type: main |
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