Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people.
| Title: | Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people. |
|---|---|
| Authors: | Mekli, Krisztina1 (AUTHOR) krisztina.mekli@manchester.ac.uk, Lophatananon, Artitaya2 (AUTHOR), Maharani, Asri3 (AUTHOR), Nazroo, James Y.1 (AUTHOR), Muir, Kenneth R.2 (AUTHOR) |
| Source: | PLoS ONE. 7/19/2023, Vol. 18 Issue 7, p1-17. 17p. |
| Subject Terms: | *ALZHEIMER'S disease, *BIOMARKERS, *VASCULAR dementia, *FLUID intelligence, *PROSPECTIVE memory |
| Geographic Terms: | UNITED Kingdom |
| Abstract: | This study was designed to investigate the relationship between a systematic inflammatory biomarker measure, concurrent and later cognitive performance, and future dementia risk. The literature has reported the potential involvement of inflammation in cognitive performance as well as Alzheimer's Disease, but not consistently. We used a population-based cohort of 500,000 people in the UK and assessed the association between a composite inflammatory biomarker and cognitive performance measures across five domains measured concurrently and 4–13 years later, taking advantage of the large sample size. We also assessed the same biomarker's association with dementia diagnosis 3–11 years later in the initially dementia-free sample. We report small but significant associations between elevated biomarker levels and worsened cognitive performance at baseline for four cognitive tasks (OR = 1.204, p<0.001 for Prospective memory, β = -0.366, p<0.001 for Fluid intelligence, β = 8.819, p<0.001 for Reaction time, and β = -0.224, p<0.001 for Numeric memory), comparing the highest quartile of the biomarker to the lowest. We also found that for one measure (Pairs matching) higher biomarker levels were associated with fewer errors, i.e. better performance (β = -0.096, p<0.001). We also report that the 4th quartiles of the baseline biomarker levels were significantly associated with cognitive task scores assessed years later on the p< = 0.002 level, except for the Pair matching test, for which none of the quartiles remained a significant predictor. Finally, the highest biomarker quartile was significantly associated with increased dementia risk compared to the lowest quartile (HR = 1.349, p<0.001). A case-only analysis to assess disease subtype heterogeneity suggested probable differences in the association with the highest biomarker quartile between vascular dementia and Alzheimer disease subtypes (OR = 1.483, p = 0.055). Our results indicate that systemic inflammation may play a small but significant part in dementia pathophysiology, especially in vascular dementia. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mekli%2C+Krisztina%22">Mekli, Krisztina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> krisztina.mekli@manchester.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Lophatananon%2C+Artitaya%22">Lophatananon, Artitaya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maharani%2C+Asri%22">Maharani, Asri</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nazroo%2C+James+Y%2E%22">Nazroo, James Y.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muir%2C+Kenneth+R%2E%22">Muir, Kenneth R.</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22PLoS+ONE%22">PLoS ONE</searchLink>. 7/19/2023, Vol. 18 Issue 7, p1-17. 17p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22ALZHEIMER'S+disease%22">ALZHEIMER'S disease</searchLink><br />*<searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br />*<searchLink fieldCode="DE" term="%22VASCULAR+dementia%22">VASCULAR dementia</searchLink><br />*<searchLink fieldCode="DE" term="%22FLUID+intelligence%22">FLUID intelligence</searchLink><br />*<searchLink fieldCode="DE" term="%22PROSPECTIVE+memory%22">PROSPECTIVE memory</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22UNITED+Kingdom%22">UNITED Kingdom</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study was designed to investigate the relationship between a systematic inflammatory biomarker measure, concurrent and later cognitive performance, and future dementia risk. The literature has reported the potential involvement of inflammation in cognitive performance as well as Alzheimer's Disease, but not consistently. We used a population-based cohort of 500,000 people in the UK and assessed the association between a composite inflammatory biomarker and cognitive performance measures across five domains measured concurrently and 4–13 years later, taking advantage of the large sample size. We also assessed the same biomarker's association with dementia diagnosis 3–11 years later in the initially dementia-free sample. We report small but significant associations between elevated biomarker levels and worsened cognitive performance at baseline for four cognitive tasks (OR = 1.204, p<0.001 for Prospective memory, β = -0.366, p<0.001 for Fluid intelligence, β = 8.819, p<0.001 for Reaction time, and β = -0.224, p<0.001 for Numeric memory), comparing the highest quartile of the biomarker to the lowest. We also found that for one measure (Pairs matching) higher biomarker levels were associated with fewer errors, i.e. better performance (β = -0.096, p<0.001). We also report that the 4th quartiles of the baseline biomarker levels were significantly associated with cognitive task scores assessed years later on the p< = 0.002 level, except for the Pair matching test, for which none of the quartiles remained a significant predictor. Finally, the highest biomarker quartile was significantly associated with increased dementia risk compared to the lowest quartile (HR = 1.349, p<0.001). A case-only analysis to assess disease subtype heterogeneity suggested probable differences in the association with the highest biomarker quartile between vascular dementia and Alzheimer disease subtypes (OR = 1.483, p = 0.055). Our results indicate that systemic inflammation may play a small but significant part in dementia pathophysiology, especially in vascular dementia. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0288045 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1 Subjects: – SubjectFull: UNITED Kingdom Type: general – SubjectFull: ALZHEIMER'S disease Type: general – SubjectFull: BIOMARKERS Type: general – SubjectFull: VASCULAR dementia Type: general – SubjectFull: FLUID intelligence Type: general – SubjectFull: PROSPECTIVE memory Type: general Titles: – TitleFull: Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mekli, Krisztina – PersonEntity: Name: NameFull: Lophatananon, Artitaya – PersonEntity: Name: NameFull: Maharani, Asri – PersonEntity: Name: NameFull: Nazroo, James Y. – PersonEntity: Name: NameFull: Muir, Kenneth R. IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 07 Text: 7/19/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 19326203 Numbering: – Type: volume Value: 18 – Type: issue Value: 7 Titles: – TitleFull: PLoS ONE Type: main |
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