The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study).
| Title: | The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study). |
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| Authors: | Elsammak, Ghada A1 (AUTHOR) ghadaelsammak@hotmail.com, Talaat, Aliaa2 (AUTHOR), Reda, Samar1 (AUTHOR) |
| Source: | Ultrastructural Pathology. 2023, Vol. 47 Issue 4, p324-338. 15p. |
| Subject Terms: | *LYCOPENE, *TRIBUTYLTIN, *BIOMARKERS, *THYROID gland, *ALBINISM, *DNA damage, *LYSOSOMES, *THYROID gland function tests, *THYROTROPIN receptors |
| Abstract: | Tributyltin is used in industrial applications. This current research aimed to study the effect of Tributyltin on the thyroid gland structure and function of adult male albino rats and the protective effect of Lycopene. Twenty-one male adult albino rats were classified into three groups: Control, treated that received Tributyltin, and protective that received Lycopene with Tributyltin. At the end of the experiment, blood samples were collected and T4, T3, and (TSH) were measured. Tissue superoxide dismutase (SOD) and malondialdehyde (MDA) were estimated. Thyroid gland specimens were processed for histological and immunohistochemical examination. Then morphometric and statistical analyses were done. The treated group showed affection in thyroid function and histological structure as vacuolated colloid and cytoplasm and dark nuclei. Ultrastructurally, follicular cells showed irregular shrunken nuclei, atrophied apical microvilli, vacuoles, multiple lysosomal granules, mitochondria with destructed cristae, and extensively dilated rough endoplasmic reticulum. There was increase in Caspase-3 immunoexpression and decrease in Beclin-1 immunoexpression. The thyroid structure and biochemical markers improved after Lycopene administration. The thyroid gland damage caused by Tributyltin is ameliorated by Lycopene. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Elsammak%2C+Ghada+A%22">Elsammak, Ghada A</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ghadaelsammak@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Talaat%2C+Aliaa%22">Talaat, Aliaa</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reda%2C+Samar%22">Reda, Samar</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Ultrastructural+Pathology%22">Ultrastructural Pathology</searchLink>. 2023, Vol. 47 Issue 4, p324-338. 15p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22LYCOPENE%22">LYCOPENE</searchLink><br />*<searchLink fieldCode="DE" term="%22TRIBUTYLTIN%22">TRIBUTYLTIN</searchLink><br />*<searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br />*<searchLink fieldCode="DE" term="%22THYROID+gland%22">THYROID gland</searchLink><br />*<searchLink fieldCode="DE" term="%22ALBINISM%22">ALBINISM</searchLink><br />*<searchLink fieldCode="DE" term="%22DNA+damage%22">DNA damage</searchLink><br />*<searchLink fieldCode="DE" term="%22LYSOSOMES%22">LYSOSOMES</searchLink><br />*<searchLink fieldCode="DE" term="%22THYROID+gland+function+tests%22">THYROID gland function tests</searchLink><br />*<searchLink fieldCode="DE" term="%22THYROTROPIN+receptors%22">THYROTROPIN receptors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Tributyltin is used in industrial applications. This current research aimed to study the effect of Tributyltin on the thyroid gland structure and function of adult male albino rats and the protective effect of Lycopene. Twenty-one male adult albino rats were classified into three groups: Control, treated that received Tributyltin, and protective that received Lycopene with Tributyltin. At the end of the experiment, blood samples were collected and T4, T3, and (TSH) were measured. Tissue superoxide dismutase (SOD) and malondialdehyde (MDA) were estimated. Thyroid gland specimens were processed for histological and immunohistochemical examination. Then morphometric and statistical analyses were done. The treated group showed affection in thyroid function and histological structure as vacuolated colloid and cytoplasm and dark nuclei. Ultrastructurally, follicular cells showed irregular shrunken nuclei, atrophied apical microvilli, vacuoles, multiple lysosomal granules, mitochondria with destructed cristae, and extensively dilated rough endoplasmic reticulum. There was increase in Caspase-3 immunoexpression and decrease in Beclin-1 immunoexpression. The thyroid structure and biochemical markers improved after Lycopene administration. The thyroid gland damage caused by Tributyltin is ameliorated by Lycopene. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Ultrastructural Pathology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/01913123.2023.2205922 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 324 Subjects: – SubjectFull: LYCOPENE Type: general – SubjectFull: TRIBUTYLTIN Type: general – SubjectFull: BIOMARKERS Type: general – SubjectFull: THYROID gland Type: general – SubjectFull: ALBINISM Type: general – SubjectFull: DNA damage Type: general – SubjectFull: LYSOSOMES Type: general – SubjectFull: THYROID gland function tests Type: general – SubjectFull: THYROTROPIN receptors Type: general Titles: – TitleFull: The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Elsammak, Ghada A – PersonEntity: Name: NameFull: Talaat, Aliaa – PersonEntity: Name: NameFull: Reda, Samar IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 01913123 Numbering: – Type: volume Value: 47 – Type: issue Value: 4 Titles: – TitleFull: Ultrastructural Pathology Type: main |
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