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Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease.

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Title: Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease.
Authors: Chiriac, Stefan1,2 (AUTHOR), Sfarti, Catalin Victor1,2 (AUTHOR) cvsfarti@gmail.com, Minea, Horia1,2 (AUTHOR) cvsfarti@gmail.com, Stanciu, Carol1,2 (AUTHOR), Cojocariu, Camelia1,2 (AUTHOR), Singeap, Ana-Maria1,2 (AUTHOR), Girleanu, Irina1,2 (AUTHOR), Cuciureanu, Tudor1,2 (AUTHOR), Petrea, Oana1,2 (AUTHOR), Huiban, Laura1,2 (AUTHOR), Muzica, Cristina Maria1,2 (AUTHOR), Zenovia, Sebastian1,2 (AUTHOR), Nastasa, Robert1,2 (AUTHOR), Stafie, Remus1,2 (AUTHOR), Rotaru, Adrian1,2 (AUTHOR), Stratina, Ermina1,2 (AUTHOR), Trifan, Anca1,2 (AUTHOR)
Source: Diagnostics (2075-4418). Apr2023, Vol. 13 Issue 7, p1230. 14p.
Subject Terms: *INFLAMMATORY bowel diseases, *PERMEABILITY, *INTESTINES, *DISEASE remission, *DISEASE relapse
Abstract: Inflammatory bowel diseases (IBD) represent a global phenomenon, with a continuously rising prevalence. The strategies concerning IBD management are progressing from clinical monitorization to a targeted approach, and current therapies strive to reduce microscopic mucosal inflammation and stimulate repair of the epithelial barrier function. Intestinal permeability has recently been receiving increased attention, as evidence suggests that it could be related to disease activity in IBD. However, most investigations do not successfully provide adequate information regarding the morphological integrity of the intestinal barrier. In this review, we discuss the advantages of confocal laser endomicroscopy (CLE), which allows in vivo visualization of histological abnormalities and targeted optical biopsies in the setting of IBD. Additionally, CLE has been used to assess vascular permeability and epithelial barrier function that could correlate with prolonged clinical remission, increased resection-free survival, and lower hospitalization rates. Moreover, the dynamic evaluation of the functional characteristics of the intestinal barrier presents an advantage over the endoscopic examination as it has the potential to select patients at risk of relapses. Along with mucosal healing, histological or transmural remission, the recovery of the intestinal barrier function emerges as a possible target that could be included in the future therapeutic strategies for IBD. [ABSTRACT FROM AUTHOR]
Copyright of Diagnostics (2075-4418) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Impaired Intestinal Permeability Assessed by Confocal Laser Endomicroscopy—A New Potential Therapeutic Target in Inflammatory Bowel Disease.
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  Data: Inflammatory bowel diseases (IBD) represent a global phenomenon, with a continuously rising prevalence. The strategies concerning IBD management are progressing from clinical monitorization to a targeted approach, and current therapies strive to reduce microscopic mucosal inflammation and stimulate repair of the epithelial barrier function. Intestinal permeability has recently been receiving increased attention, as evidence suggests that it could be related to disease activity in IBD. However, most investigations do not successfully provide adequate information regarding the morphological integrity of the intestinal barrier. In this review, we discuss the advantages of confocal laser endomicroscopy (CLE), which allows in vivo visualization of histological abnormalities and targeted optical biopsies in the setting of IBD. Additionally, CLE has been used to assess vascular permeability and epithelial barrier function that could correlate with prolonged clinical remission, increased resection-free survival, and lower hospitalization rates. Moreover, the dynamic evaluation of the functional characteristics of the intestinal barrier presents an advantage over the endoscopic examination as it has the potential to select patients at risk of relapses. Along with mucosal healing, histological or transmural remission, the recovery of the intestinal barrier function emerges as a possible target that could be included in the future therapeutic strategies for IBD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Diagnostics (2075-4418) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/diagnostics13071230
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        Text: English
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      – SubjectFull: INFLAMMATORY bowel diseases
        Type: general
      – SubjectFull: PERMEABILITY
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      – SubjectFull: INTESTINES
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