What's New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD).
| Title: | What's New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). |
|---|---|
| Authors: | Kosmalski, Marcin1 (AUTHOR) marcin.kosmalski@umed.lodz.pl, Frankowski, Rafał2 (AUTHOR), Ziółkowska, Sylwia3 (AUTHOR), Różycka-Kosmalska, Monika4 (AUTHOR), Pietras, Tadeusz1 (AUTHOR) |
| Source: | Journal of Clinical Medicine. Mar2023, Vol. 12 Issue 5, p1852. 27p. |
| Subject Terms: | *NON-alcoholic fatty liver disease, *HIGH-protein diet, *MEDITERRANEAN diet, *AEROBIC exercises |
| Abstract: | Non-alcoholic fatty liver disease (NAFLD) is a serious health problem due to its high incidence and consequences. In view of the existing controversies, new therapeutic options for NAFLD are still being sought. Therefore, the aim of our review was to evaluate the recently published studies on the treatment of NAFLD patients. We searched for articles in the PubMed database using appropriate terms, including "non-alcoholic fatty liver disease", "nonalcoholic fatty liver disease", "NAFLD", "diet", "treatment", "physical activity", "supplementation", "surgery", "overture" and "guidelines". One hundred forty-eight randomized clinical trials published from January 2020 to November 2022 were used for the final analysis. The results show significant benefits of NAFLD therapy associated with the use of not only the Mediterranean but also other types of diet (including low-calorie ketogenic, high-protein, anti-inflammatory and whole-grain diets), as well as enrichment with selected food products or supplements. Significant benefits in this group of patients are also associated with moderate aerobic physical training. The available therapeutic options indicate, above all, the usefulness of drugs related to weight reduction, as well as the reduction in insulin resistance or lipids level and drugs with anti-inflammatory or antioxidant properties. The usefulness of therapy with dulaglutide and the combination of tofogliflozin with pioglitazone should be emphasized. Based on the results of the latest research, the authors of this article suggest a revision of the therapeutic recommendations for NAFLD patients. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: What's New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kosmalski%2C+Marcin%22">Kosmalski, Marcin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> marcin.kosmalski@umed.lodz.pl</i><br /><searchLink fieldCode="AR" term="%22Frankowski%2C+Rafał%22">Frankowski, Rafał</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ziółkowska%2C+Sylwia%22">Ziółkowska, Sylwia</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Różycka-Kosmalska%2C+Monika%22">Różycka-Kosmalska, Monika</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pietras%2C+Tadeusz%22">Pietras, Tadeusz</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+Medicine%22">Journal of Clinical Medicine</searchLink>. Mar2023, Vol. 12 Issue 5, p1852. 27p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22NON-alcoholic+fatty+liver+disease%22">NON-alcoholic fatty liver disease</searchLink><br />*<searchLink fieldCode="DE" term="%22HIGH-protein+diet%22">HIGH-protein diet</searchLink><br />*<searchLink fieldCode="DE" term="%22MEDITERRANEAN+diet%22">MEDITERRANEAN diet</searchLink><br />*<searchLink fieldCode="DE" term="%22AEROBIC+exercises%22">AEROBIC exercises</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Non-alcoholic fatty liver disease (NAFLD) is a serious health problem due to its high incidence and consequences. In view of the existing controversies, new therapeutic options for NAFLD are still being sought. Therefore, the aim of our review was to evaluate the recently published studies on the treatment of NAFLD patients. We searched for articles in the PubMed database using appropriate terms, including "non-alcoholic fatty liver disease", "nonalcoholic fatty liver disease", "NAFLD", "diet", "treatment", "physical activity", "supplementation", "surgery", "overture" and "guidelines". One hundred forty-eight randomized clinical trials published from January 2020 to November 2022 were used for the final analysis. The results show significant benefits of NAFLD therapy associated with the use of not only the Mediterranean but also other types of diet (including low-calorie ketogenic, high-protein, anti-inflammatory and whole-grain diets), as well as enrichment with selected food products or supplements. Significant benefits in this group of patients are also associated with moderate aerobic physical training. The available therapeutic options indicate, above all, the usefulness of drugs related to weight reduction, as well as the reduction in insulin resistance or lipids level and drugs with anti-inflammatory or antioxidant properties. The usefulness of therapy with dulaglutide and the combination of tofogliflozin with pioglitazone should be emphasized. Based on the results of the latest research, the authors of this article suggest a revision of the therapeutic recommendations for NAFLD patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/jcm12051852 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 27 StartPage: 1852 Subjects: – SubjectFull: NON-alcoholic fatty liver disease Type: general – SubjectFull: HIGH-protein diet Type: general – SubjectFull: MEDITERRANEAN diet Type: general – SubjectFull: AEROBIC exercises Type: general Titles: – TitleFull: What's New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kosmalski, Marcin – PersonEntity: Name: NameFull: Frankowski, Rafał – PersonEntity: Name: NameFull: Ziółkowska, Sylwia – PersonEntity: Name: NameFull: Różycka-Kosmalska, Monika – PersonEntity: Name: NameFull: Pietras, Tadeusz IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20770383 Numbering: – Type: volume Value: 12 – Type: issue Value: 5 Titles: – TitleFull: Journal of Clinical Medicine Type: main |
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