Utilization of Prognostic Biomarker Soluble Urokinase Plasminogen Activator Receptor in the Emergency Department: A Tool for Safe and More Efficient Decision-making.
| Title: | Utilization of Prognostic Biomarker Soluble Urokinase Plasminogen Activator Receptor in the Emergency Department: A Tool for Safe and More Efficient Decision-making. |
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| Authors: | Holstein, Ria M1 (AUTHOR) ria.holstein@helsinki.fi, Mäkinen, Marja T1 (AUTHOR), Castrén, Maaret K1 (AUTHOR), Kaartinen, Johanna M1 (AUTHOR) |
| Source: | Biomarker Insights. 3/9/2022, Vol. 17, p1-7. 7p. |
| Subject Terms: | *PLASMINOGEN activators, *UROKINASE, *HOSPITAL emergency services, *BIOMARKERS, *OLDER people, *PLASMINOGEN |
| Abstract: | Introduction: Risk stratification in the emergency departments (EDs) is in critical need for new applications due to ED overcrowding and hospitalization of older people. We aimed to evaluate the expediency, efficiency and safety of a prognostic biomarker, soluble urokinase plasminogen activator receptor (suPAR), as a tool for the risk assessment of patients arriving at the ED. Methods: We performed a comparative cross-sectional study in 2 emergency departments (EDs), suPAR measurements being incorporated into routine blood sampling in the intervention ED. The primary outcome was the number of discharges from the ED. The importance of the outcomes was examined by appropriate multi- or bivariate analysis. Results: The absolute and relative number of discharges were similar between the intervention and control groups [121 (55.3%) vs 62 (55.9%)]. No significant differences between the groups were seen in the length of stays in the ED. Patients with low suPAR values were more likely discharged and patients with high suPAR values more likely admitted to hospital. Two admitted patients with low suPAR values could have been discharged safely. Conclusion: The utilization of suPAR did not increase the risk for neither positive nor negative outcomes. Low suPAR values could be potential in discharging more patients safely. Instead of unselected patient populations, the benefits of suPAR measurements in the ED could emerge in the assessment of a more precisely determined and selected group of patients. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Utilization of Prognostic Biomarker Soluble Urokinase Plasminogen Activator Receptor in the Emergency Department: A Tool for Safe and More Efficient Decision-making. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Holstein%2C+Ria+M%22">Holstein, Ria M</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> ria.holstein@helsinki.fi</i><br /><searchLink fieldCode="AR" term="%22Mäkinen%2C+Marja+T%22">Mäkinen, Marja T</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Castrén%2C+Maaret+K%22">Castrén, Maaret K</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaartinen%2C+Johanna+M%22">Kaartinen, Johanna M</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomarker+Insights%22">Biomarker Insights</searchLink>. 3/9/2022, Vol. 17, p1-7. 7p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22PLASMINOGEN+activators%22">PLASMINOGEN activators</searchLink><br />*<searchLink fieldCode="DE" term="%22UROKINASE%22">UROKINASE</searchLink><br />*<searchLink fieldCode="DE" term="%22HOSPITAL+emergency+services%22">HOSPITAL emergency services</searchLink><br />*<searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br />*<searchLink fieldCode="DE" term="%22OLDER+people%22">OLDER people</searchLink><br />*<searchLink fieldCode="DE" term="%22PLASMINOGEN%22">PLASMINOGEN</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: Risk stratification in the emergency departments (EDs) is in critical need for new applications due to ED overcrowding and hospitalization of older people. We aimed to evaluate the expediency, efficiency and safety of a prognostic biomarker, soluble urokinase plasminogen activator receptor (suPAR), as a tool for the risk assessment of patients arriving at the ED. Methods: We performed a comparative cross-sectional study in 2 emergency departments (EDs), suPAR measurements being incorporated into routine blood sampling in the intervention ED. The primary outcome was the number of discharges from the ED. The importance of the outcomes was examined by appropriate multi- or bivariate analysis. Results: The absolute and relative number of discharges were similar between the intervention and control groups [121 (55.3%) vs 62 (55.9%)]. No significant differences between the groups were seen in the length of stays in the ED. Patients with low suPAR values were more likely discharged and patients with high suPAR values more likely admitted to hospital. Two admitted patients with low suPAR values could have been discharged safely. Conclusion: The utilization of suPAR did not increase the risk for neither positive nor negative outcomes. Low suPAR values could be potential in discharging more patients safely. Instead of unselected patient populations, the benefits of suPAR measurements in the ED could emerge in the assessment of a more precisely determined and selected group of patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomarker Insights is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/11772719221081789 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1 Subjects: – SubjectFull: PLASMINOGEN activators Type: general – SubjectFull: UROKINASE Type: general – SubjectFull: HOSPITAL emergency services Type: general – SubjectFull: BIOMARKERS Type: general – SubjectFull: OLDER people Type: general – SubjectFull: PLASMINOGEN Type: general Titles: – TitleFull: Utilization of Prognostic Biomarker Soluble Urokinase Plasminogen Activator Receptor in the Emergency Department: A Tool for Safe and More Efficient Decision-making. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Holstein, Ria M – PersonEntity: Name: NameFull: Mäkinen, Marja T – PersonEntity: Name: NameFull: Castrén, Maaret K – PersonEntity: Name: NameFull: Kaartinen, Johanna M IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 03 Text: 3/9/2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 11772719 Numbering: – Type: volume Value: 17 Titles: – TitleFull: Biomarker Insights Type: main |
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