Academic Journal
View in EDS
HTML Full Text

Diagnostic and Therapeutic Pathway of Advanced Ovarian Cancer with Peritoneal Metastases.

Bibliographic Details
Title: Diagnostic and Therapeutic Pathway of Advanced Ovarian Cancer with Peritoneal Metastases.
Authors: Ghirardi, Valentina1 (AUTHOR) valentina.ghirardi@policlinicogemelli.it, Fagotti, Anna1 (AUTHOR), Ansaloni, Luca2 (AUTHOR), Valle, Mario3 (AUTHOR), Roviello, Franco4 (AUTHOR), Sorrentino, Lorena5 (AUTHOR), Accarpio, Fabio6 (AUTHOR), Baiocchi, Gianluca7 (AUTHOR), Piccini, Lorenzo8 (AUTHOR), De Simone, Michele9 (AUTHOR), Coccolini, Federico10 (AUTHOR), Visaloco, Mario11 (AUTHOR), Bacchetti, Stefano12 (AUTHOR), Scambia, Giovanni1 (AUTHOR), Marrelli, Daniele4 (AUTHOR)
Source: Cancers. Jan2023, Vol. 15 Issue 2, p407. 12p.
Subject Terms: *OVARIAN tumors, *PERITONEUM diseases, *CANCER chemotherapy, *LAPAROSCOPY, *COMBINED modality therapy, *CYTOREDUCTIVE surgery, *TUMOR markers
Abstract: Simple Summary: As ovarian cancer represents the most lethal gynecological malignancy, the diagnostic process represents a crucial step in order to select the appropriate treatment strategy. Indeed, the association of tumor marker levels with radiological imaging and an evaluation of tumor load with diagnostic laparoscopy are essential to assess whether the patients are best treated by upfront surgery or neo-adjuvant chemotherapy followed by interval debulking surgery. With this review, we aim to provide most relevant available evidence on the diagnostic and treatment pathway of advanced ovarian cancer. Over two thirds of ovarian cancer patients present with advanced stage disease at the time of diagnosis. In this scenario, standard treatment includes a combination of cytoreductive surgery and carboplatinum–paclitaxel-based chemotherapy. Despite the survival advantage of patients treated with upfront cytoreductive surgery compared to women undergoing neo-adjuvant chemotherapy (NACT) and interval debulking surgery (IDS) due to high tumor load or poor performance status has been demonstrated by multiple studies, this topic is still a matter of debate. As a consequence, selecting the adequate treatment through an appropriate diagnostic pathway represents a crucial step. Aiming to assess the likelihood of leaving no residual disease at the end of surgery, the role of the CT scan as a predictor of cytoreductive outcomes has shown controversial results. Similarly, CA 125 level as an expression of tumor load demonstrated limited applicability. On the contrary, laparoscopic assessment of disease distribution through a validated scoring system was able to identify, with the highest specificity, patients undergoing suboptimal cytoreduction and therefore best suitable for NACT-IDS. Against this background, with this article, we aim to provide a comprehensive review of available evidence on the diagnostic and treatment pathways of advanced ovarian cancer. [ABSTRACT FROM AUTHOR]
Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=20726694&ISBN=&volume=15&issue=2&date=20230115&spage=407&pages=407-418&title=Cancers&atitle=Diagnostic%20and%20Therapeutic%20Pathway%20of%20Advanced%20Ovarian%20Cancer%20with%20Peritoneal%20Metastases.&aulast=Ghirardi%2C%20Valentina&id=DOI:10.3390/cancers15020407
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 161438779
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Diagnostic and Therapeutic Pathway of Advanced Ovarian Cancer with Peritoneal Metastases.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ghirardi%2C+Valentina%22">Ghirardi, Valentina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> valentina.ghirardi@policlinicogemelli.it</i><br /><searchLink fieldCode="AR" term="%22Fagotti%2C+Anna%22">Fagotti, Anna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ansaloni%2C+Luca%22">Ansaloni, Luca</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valle%2C+Mario%22">Valle, Mario</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roviello%2C+Franco%22">Roviello, Franco</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sorrentino%2C+Lorena%22">Sorrentino, Lorena</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Accarpio%2C+Fabio%22">Accarpio, Fabio</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baiocchi%2C+Gianluca%22">Baiocchi, Gianluca</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piccini%2C+Lorenzo%22">Piccini, Lorenzo</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Simone%2C+Michele%22">De Simone, Michele</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coccolini%2C+Federico%22">Coccolini, Federico</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Visaloco%2C+Mario%22">Visaloco, Mario</searchLink><relatesTo>11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bacchetti%2C+Stefano%22">Bacchetti, Stefano</searchLink><relatesTo>12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scambia%2C+Giovanni%22">Scambia, Giovanni</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marrelli%2C+Daniele%22">Marrelli, Daniele</searchLink><relatesTo>4</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Cancers%22">Cancers</searchLink>. Jan2023, Vol. 15 Issue 2, p407. 12p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22OVARIAN+tumors%22">OVARIAN tumors</searchLink><br />*<searchLink fieldCode="DE" term="%22PERITONEUM+diseases%22">PERITONEUM diseases</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+chemotherapy%22">CANCER chemotherapy</searchLink><br />*<searchLink fieldCode="DE" term="%22LAPAROSCOPY%22">LAPAROSCOPY</searchLink><br />*<searchLink fieldCode="DE" term="%22COMBINED+modality+therapy%22">COMBINED modality therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22CYTOREDUCTIVE+surgery%22">CYTOREDUCTIVE surgery</searchLink><br />*<searchLink fieldCode="DE" term="%22TUMOR+markers%22">TUMOR markers</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Simple Summary: As ovarian cancer represents the most lethal gynecological malignancy, the diagnostic process represents a crucial step in order to select the appropriate treatment strategy. Indeed, the association of tumor marker levels with radiological imaging and an evaluation of tumor load with diagnostic laparoscopy are essential to assess whether the patients are best treated by upfront surgery or neo-adjuvant chemotherapy followed by interval debulking surgery. With this review, we aim to provide most relevant available evidence on the diagnostic and treatment pathway of advanced ovarian cancer. Over two thirds of ovarian cancer patients present with advanced stage disease at the time of diagnosis. In this scenario, standard treatment includes a combination of cytoreductive surgery and carboplatinum–paclitaxel-based chemotherapy. Despite the survival advantage of patients treated with upfront cytoreductive surgery compared to women undergoing neo-adjuvant chemotherapy (NACT) and interval debulking surgery (IDS) due to high tumor load or poor performance status has been demonstrated by multiple studies, this topic is still a matter of debate. As a consequence, selecting the adequate treatment through an appropriate diagnostic pathway represents a crucial step. Aiming to assess the likelihood of leaving no residual disease at the end of surgery, the role of the CT scan as a predictor of cytoreductive outcomes has shown controversial results. Similarly, CA 125 level as an expression of tumor load demonstrated limited applicability. On the contrary, laparoscopic assessment of disease distribution through a validated scoring system was able to identify, with the highest specificity, patients undergoing suboptimal cytoreduction and therefore best suitable for NACT-IDS. Against this background, with this article, we aim to provide a comprehensive review of available evidence on the diagnostic and treatment pathways of advanced ovarian cancer. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=161438779
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/cancers15020407
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 407
    Subjects:
      – SubjectFull: OVARIAN tumors
        Type: general
      – SubjectFull: PERITONEUM diseases
        Type: general
      – SubjectFull: CANCER chemotherapy
        Type: general
      – SubjectFull: LAPAROSCOPY
        Type: general
      – SubjectFull: COMBINED modality therapy
        Type: general
      – SubjectFull: CYTOREDUCTIVE surgery
        Type: general
      – SubjectFull: TUMOR markers
        Type: general
    Titles:
      – TitleFull: Diagnostic and Therapeutic Pathway of Advanced Ovarian Cancer with Peritoneal Metastases.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ghirardi, Valentina
      – PersonEntity:
          Name:
            NameFull: Fagotti, Anna
      – PersonEntity:
          Name:
            NameFull: Ansaloni, Luca
      – PersonEntity:
          Name:
            NameFull: Valle, Mario
      – PersonEntity:
          Name:
            NameFull: Roviello, Franco
      – PersonEntity:
          Name:
            NameFull: Sorrentino, Lorena
      – PersonEntity:
          Name:
            NameFull: Accarpio, Fabio
      – PersonEntity:
          Name:
            NameFull: Baiocchi, Gianluca
      – PersonEntity:
          Name:
            NameFull: Piccini, Lorenzo
      – PersonEntity:
          Name:
            NameFull: De Simone, Michele
      – PersonEntity:
          Name:
            NameFull: Coccolini, Federico
      – PersonEntity:
          Name:
            NameFull: Visaloco, Mario
      – PersonEntity:
          Name:
            NameFull: Bacchetti, Stefano
      – PersonEntity:
          Name:
            NameFull: Scambia, Giovanni
      – PersonEntity:
          Name:
            NameFull: Marrelli, Daniele
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 01
              Text: Jan2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 20726694
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Cancers
              Type: main
ResultId 1