Plasma metabolomic profiles reveal sex- and maturation-dependent metabolic strategies in sea lamprey (Petromyzon marinus).
| Title: | Plasma metabolomic profiles reveal sex- and maturation-dependent metabolic strategies in sea lamprey (Petromyzon marinus). |
|---|---|
| Authors: | Tamrakar, Sonam1 (AUTHOR), Huerta, Belinda2 (AUTHOR), Chung-Davidson, Yu-Wen1 (AUTHOR), Li, Weiming1 (AUTHOR) liweim@msu.edu |
| Source: | Metabolomics. Nov2022, Vol. 18 Issue 11, p1-10. 10p. |
| Subject Terms: | *SEA lamprey, *NEST building, *AMINO acid metabolism, *METABOLOMICS, *FEMALES, *BILE acids, *CARBOHYDRATE metabolism |
| Abstract: | Introduction: Adult sea lamprey (Petromyzon marinus) cease feeding and migrate to spawning streams where males build nests, undergo final sexual maturation, and subsequently produce and release large quantities of bile acid pheromones that attract mature females. These animals are predicted to rearrange their metabolic pathways drastically to support their reproductive strategies, presenting advantageous opportunities to examine how sex and the maturation processes affect metabolism. Objectives: The objective is to investigate the metabolic differences between sexes and maturation states in sea lamprey that support changes in physiological functions. Methods: We compared plasma metabolomes of spawning and prespawning sea lamprey in both sexes using both non-targeted and targeted metabolomics approaches using UPLC/MS–MS with electrospray ionization in both positive and negative modes. The data were processed using Progenesis QI, Compound Discoverer and XCMS softwares for alignment, peak picking, and deconvolution of the peaks. Principle component analyses (PCA) and partial least squares discriminant analyses (PLS-DA) were performed using SIMCA and Metaboanalyst softwares to identify discriminating features, followed by fragmentation matching with extensive database search and pathway mapping. Results: The pheromonal bile acid biosynthesis was upregulated significantly in males compared to females. Spermiating males further upregulated bile acid biosynthesis by altering amino acid metabolisms, upregulating cofactors and nucleotide metabolisms, but downregulating carbohydrate and energy metabolisms. Conclusion: Plasma metabolomes are sex- and maturation-dependent and reflect the special metabolic demands at each life stage and reproductive strategy. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Plasma metabolomic profiles reveal sex- and maturation-dependent metabolic strategies in sea lamprey (Petromyzon marinus). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tamrakar%2C+Sonam%22">Tamrakar, Sonam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huerta%2C+Belinda%22">Huerta, Belinda</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung-Davidson%2C+Yu-Wen%22">Chung-Davidson, Yu-Wen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Weiming%22">Li, Weiming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> liweim@msu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Metabolomics%22">Metabolomics</searchLink>. Nov2022, Vol. 18 Issue 11, p1-10. 10p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22SEA+lamprey%22">SEA lamprey</searchLink><br />*<searchLink fieldCode="DE" term="%22NEST+building%22">NEST building</searchLink><br />*<searchLink fieldCode="DE" term="%22AMINO+acid+metabolism%22">AMINO acid metabolism</searchLink><br />*<searchLink fieldCode="DE" term="%22METABOLOMICS%22">METABOLOMICS</searchLink><br />*<searchLink fieldCode="DE" term="%22FEMALES%22">FEMALES</searchLink><br />*<searchLink fieldCode="DE" term="%22BILE+acids%22">BILE acids</searchLink><br />*<searchLink fieldCode="DE" term="%22CARBOHYDRATE+metabolism%22">CARBOHYDRATE metabolism</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: Adult sea lamprey (Petromyzon marinus) cease feeding and migrate to spawning streams where males build nests, undergo final sexual maturation, and subsequently produce and release large quantities of bile acid pheromones that attract mature females. These animals are predicted to rearrange their metabolic pathways drastically to support their reproductive strategies, presenting advantageous opportunities to examine how sex and the maturation processes affect metabolism. Objectives: The objective is to investigate the metabolic differences between sexes and maturation states in sea lamprey that support changes in physiological functions. Methods: We compared plasma metabolomes of spawning and prespawning sea lamprey in both sexes using both non-targeted and targeted metabolomics approaches using UPLC/MS–MS with electrospray ionization in both positive and negative modes. The data were processed using Progenesis QI, Compound Discoverer and XCMS softwares for alignment, peak picking, and deconvolution of the peaks. Principle component analyses (PCA) and partial least squares discriminant analyses (PLS-DA) were performed using SIMCA and Metaboanalyst softwares to identify discriminating features, followed by fragmentation matching with extensive database search and pathway mapping. Results: The pheromonal bile acid biosynthesis was upregulated significantly in males compared to females. Spermiating males further upregulated bile acid biosynthesis by altering amino acid metabolisms, upregulating cofactors and nucleotide metabolisms, but downregulating carbohydrate and energy metabolisms. Conclusion: Plasma metabolomes are sex- and maturation-dependent and reflect the special metabolic demands at each life stage and reproductive strategy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Metabolomics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11306-022-01951-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: SEA lamprey Type: general – SubjectFull: NEST building Type: general – SubjectFull: AMINO acid metabolism Type: general – SubjectFull: METABOLOMICS Type: general – SubjectFull: FEMALES Type: general – SubjectFull: BILE acids Type: general – SubjectFull: CARBOHYDRATE metabolism Type: general Titles: – TitleFull: Plasma metabolomic profiles reveal sex- and maturation-dependent metabolic strategies in sea lamprey (Petromyzon marinus). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tamrakar, Sonam – PersonEntity: Name: NameFull: Huerta, Belinda – PersonEntity: Name: NameFull: Chung-Davidson, Yu-Wen – PersonEntity: Name: NameFull: Li, Weiming IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 15733882 Numbering: – Type: volume Value: 18 – Type: issue Value: 11 Titles: – TitleFull: Metabolomics Type: main |
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