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Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.

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Title: Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.
Authors: Mugarza, Edurne1, van Maldegem, Febe1, Boumelha, Jesse1, Moore, Christopher1, Rana, Sareena1, Sopena, Miriam Llorian2, East, Philip2, Ambler, Rachel1, Anastasiou, Panayiotis1, Romero-Clavijo, Pablo1, Valand, Karishma1, Cole, Megan1, Molina-Arcas, Miriam1 miriam.molina@crick.ac.uk, Downward, Julian1,3 julian.downward@crick.ac.uk
Source: Science Advances. 7/22/2022, Vol. 8 Issue 29, p1-19. 19p.
Subject Terms: *MACROPHAGE colony-stimulating factor, *T cells, *ANTIGEN presenting cells, *LUNG cancer, *GENETIC regulation, *RAS proteins
Abstract: The article presents a study on a therapeutic KRASG12C (glycine 12 to cysteine) inhibitor that drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. It discusses that the in vivo KRASG12C inhibitor increases the T cell infiltration and activation. It also describes the mechanism of the KRASG12C inhibition reverses immunosuppression in several preclinical lung cancer models with varying levels of immunogenicity.
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  Data: Therapeutic KRAS<superscript>G12C</superscript> inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.
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  Data: <searchLink fieldCode="AR" term="%22Mugarza%2C+Edurne%22">Mugarza, Edurne</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22van+Maldegem%2C+Febe%22">van Maldegem, Febe</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Boumelha%2C+Jesse%22">Boumelha, Jesse</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Moore%2C+Christopher%22">Moore, Christopher</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rana%2C+Sareena%22">Rana, Sareena</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sopena%2C+Miriam+Llorian%22">Sopena, Miriam Llorian</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22East%2C+Philip%22">East, Philip</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ambler%2C+Rachel%22">Ambler, Rachel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Anastasiou%2C+Panayiotis%22">Anastasiou, Panayiotis</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Romero-Clavijo%2C+Pablo%22">Romero-Clavijo, Pablo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Valand%2C+Karishma%22">Valand, Karishma</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cole%2C+Megan%22">Cole, Megan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Molina-Arcas%2C+Miriam%22">Molina-Arcas, Miriam</searchLink><relatesTo>1</relatesTo><i> miriam.molina@crick.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Downward%2C+Julian%22">Downward, Julian</searchLink><relatesTo>1,3</relatesTo><i> julian.downward@crick.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Science+Advances%22">Science Advances</searchLink>. 7/22/2022, Vol. 8 Issue 29, p1-19. 19p.
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  Data: The article presents a study on a therapeutic KRASG12C (glycine 12 to cysteine) inhibitor that drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. It discusses that the in vivo KRASG12C inhibitor increases the T cell infiltration and activation. It also describes the mechanism of the KRASG12C inhibition reverses immunosuppression in several preclinical lung cancer models with varying levels of immunogenicity.
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        Value: 10.1126/sciadv.abm8780
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        Text: English
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      – SubjectFull: MACROPHAGE colony-stimulating factor
        Type: general
      – SubjectFull: T cells
        Type: general
      – SubjectFull: ANTIGEN presenting cells
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      – SubjectFull: LUNG cancer
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      – SubjectFull: GENETIC regulation
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      – SubjectFull: RAS proteins
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            – D: 22
              M: 07
              Text: 7/22/2022
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              Y: 2022
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