Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities.
| Title: | Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities. |
|---|---|
| Authors: | Hafez Ghoran, Salar1,2 (AUTHOR) a.mozafari@uok.ac.ir, Taktaz, Fatemeh3 (AUTHOR) f.taktaz@gmail.com, Mozafari, Ali Akbar2 (AUTHOR), Tunçtürk, Murat4 (AUTHOR) murattuncturk@yyu.edu.tr, Sekeroglu, Nazim5 (AUTHOR) nsekeroglu@gmail.com, Kijjoa, Anake6 (AUTHOR) s_hafezghoran@yahoo.com |
| Source: | Molecules. Feb2022, Vol. 27 Issue 3, p1128. 1p. |
| Subject Terms: | *TERPENES, *SALVIA, *METABOLITES, *ACID derivatives, *PHENYLPROPANOIDS, *PHYTOCHEMICALS, *ISOQUINOLINE alkaloids, *SAPONINS |
| Abstract: | The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus Salvia L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus Salvia, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from Salvia species, viz. C23-terpenoids, sesterterpenoids (C25), dammarane triterpenoids (C30), and uncommon triterpenoids (C20+C10). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hafez+Ghoran%2C+Salar%22">Hafez Ghoran, Salar</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> a.mozafari@uok.ac.ir</i><br /><searchLink fieldCode="AR" term="%22Taktaz%2C+Fatemeh%22">Taktaz, Fatemeh</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> f.taktaz@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Mozafari%2C+Ali+Akbar%22">Mozafari, Ali Akbar</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tunçtürk%2C+Murat%22">Tunçtürk, Murat</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> murattuncturk@yyu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Sekeroglu%2C+Nazim%22">Sekeroglu, Nazim</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> nsekeroglu@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Kijjoa%2C+Anake%22">Kijjoa, Anake</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> s_hafezghoran@yahoo.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecules%22">Molecules</searchLink>. Feb2022, Vol. 27 Issue 3, p1128. 1p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22TERPENES%22">TERPENES</searchLink><br />*<searchLink fieldCode="DE" term="%22SALVIA%22">SALVIA</searchLink><br />*<searchLink fieldCode="DE" term="%22METABOLITES%22">METABOLITES</searchLink><br />*<searchLink fieldCode="DE" term="%22ACID+derivatives%22">ACID derivatives</searchLink><br />*<searchLink fieldCode="DE" term="%22PHENYLPROPANOIDS%22">PHENYLPROPANOIDS</searchLink><br />*<searchLink fieldCode="DE" term="%22PHYTOCHEMICALS%22">PHYTOCHEMICALS</searchLink><br />*<searchLink fieldCode="DE" term="%22ISOQUINOLINE+alkaloids%22">ISOQUINOLINE alkaloids</searchLink><br />*<searchLink fieldCode="DE" term="%22SAPONINS%22">SAPONINS</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus Salvia L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus Salvia, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from Salvia species, viz. C23-terpenoids, sesterterpenoids (C25), dammarane triterpenoids (C30), and uncommon triterpenoids (C20+C10). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecules is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/molecules27031128 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 1128 Subjects: – SubjectFull: TERPENES Type: general – SubjectFull: SALVIA Type: general – SubjectFull: METABOLITES Type: general – SubjectFull: ACID derivatives Type: general – SubjectFull: PHENYLPROPANOIDS Type: general – SubjectFull: PHYTOCHEMICALS Type: general – SubjectFull: ISOQUINOLINE alkaloids Type: general – SubjectFull: SAPONINS Type: general Titles: – TitleFull: Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hafez Ghoran, Salar – PersonEntity: Name: NameFull: Taktaz, Fatemeh – PersonEntity: Name: NameFull: Mozafari, Ali Akbar – PersonEntity: Name: NameFull: Tunçtürk, Murat – PersonEntity: Name: NameFull: Sekeroglu, Nazim – PersonEntity: Name: NameFull: Kijjoa, Anake IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 14203049 Numbering: – Type: volume Value: 27 – Type: issue Value: 3 Titles: – TitleFull: Molecules Type: main |
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