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Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.

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Title: Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
Authors: Goedhart, Marieke1 (AUTHOR) m.goedhart@hezelburcht.com, Slot, Edith1 (AUTHOR) edith.sloat@sanquin.nl, Pascutti, Maria F.1 (AUTHOR) m.f.pascutti@lumc.nl, Geerman, Sulima1 (AUTHOR) sulima_geerman@hotmail.com, Rademakers, Timo2 (AUTHOR) t.rademakers@maastrichtuniversity.nl, Nota, Benjamin3 (AUTHOR) benjamin.nota@gmail.com, Huveneers, Stephan2,4 (AUTHOR) s.huveneers@amsterdamumc.nl, Buul, Jaap D. van2,4 (AUTHOR) j.vanbuul@sanquin.nl, MacNamara, Katherine C.5 (AUTHOR) macnamk@amc.edu, Voermans, Carlijn1,4 (AUTHOR) c.voermans@sanquin.nl, Nolte, Martijn A.1,3,4 (AUTHOR) martijnnolte@gmail.com
Source: Cells (2073-4409). Jan2022, Vol. 11 Issue 1, p55. 1p.
Subject Terms: *BONE marrow, *CELL populations, *DENDRITIC cells, *HEMATOPOIETIC stem cells, *NEUTROPHILS, *PHAGOCYTOSIS, *HEMATOPOIESIS, *T cells
Abstract: Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are localized around sinusoids, can (cross)-present antigens, become activated upon intravenous LPS-injection, and for the most part belong to the cDC2 subtype which is associated with Th2/Th17 immunity. Gene-expression profiling revealed that BM-resident DCs are enriched for several c-type lectins, including Dectin-1, which can bind beta-glucans expressed on fungi and yeast. Indeed, DCs in BM were much more efficient in phagocytosis of both yeast-derived zymosan-particles and Aspergillus conidiae than their splenic counterparts, which was highly dependent on Dectin-1. DCs in human BM could also phagocytose zymosan, which was dependent on β1-integrins. Moreover, zymosan-stimulated BM-resident DCs enhanced the differentiation of hematopoietic stem and progenitor cells towards neutrophils, while also boosting the maintenance of these progenitors. Our findings signify an important role for BM DCs as translators between infection and hematopoiesis, particularly in anti-fungal immunity. The ability of BM-resident DCs to boost neutrophil formation is relevant from a clinical perspective and contributes to our understanding of the increased susceptibility for fungal infections following BM damage. [ABSTRACT FROM AUTHOR]
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  Data: Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
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  Data: <searchLink fieldCode="AR" term="%22Goedhart%2C+Marieke%22">Goedhart, Marieke</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> m.goedhart@hezelburcht.com</i><br /><searchLink fieldCode="AR" term="%22Slot%2C+Edith%22">Slot, Edith</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> edith.sloat@sanquin.nl</i><br /><searchLink fieldCode="AR" term="%22Pascutti%2C+Maria+F%2E%22">Pascutti, Maria F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> m.f.pascutti@lumc.nl</i><br /><searchLink fieldCode="AR" term="%22Geerman%2C+Sulima%22">Geerman, Sulima</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sulima_geerman@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Rademakers%2C+Timo%22">Rademakers, Timo</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> t.rademakers@maastrichtuniversity.nl</i><br /><searchLink fieldCode="AR" term="%22Nota%2C+Benjamin%22">Nota, Benjamin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> benjamin.nota@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Huveneers%2C+Stephan%22">Huveneers, Stephan</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<i> s.huveneers@amsterdamumc.nl</i><br /><searchLink fieldCode="AR" term="%22Buul%2C+Jaap+D%2E+van%22">Buul, Jaap D. van</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<i> j.vanbuul@sanquin.nl</i><br /><searchLink fieldCode="AR" term="%22MacNamara%2C+Katherine+C%2E%22">MacNamara, Katherine C.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> macnamk@amc.edu</i><br /><searchLink fieldCode="AR" term="%22Voermans%2C+Carlijn%22">Voermans, Carlijn</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> c.voermans@sanquin.nl</i><br /><searchLink fieldCode="AR" term="%22Nolte%2C+Martijn+A%2E%22">Nolte, Martijn A.</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<i> martijnnolte@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Cells+%282073-4409%29%22">Cells (2073-4409)</searchLink>. Jan2022, Vol. 11 Issue 1, p55. 1p.
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  Data: *<searchLink fieldCode="DE" term="%22BONE+marrow%22">BONE marrow</searchLink><br />*<searchLink fieldCode="DE" term="%22CELL+populations%22">CELL populations</searchLink><br />*<searchLink fieldCode="DE" term="%22DENDRITIC+cells%22">DENDRITIC cells</searchLink><br />*<searchLink fieldCode="DE" term="%22HEMATOPOIETIC+stem+cells%22">HEMATOPOIETIC stem cells</searchLink><br />*<searchLink fieldCode="DE" term="%22NEUTROPHILS%22">NEUTROPHILS</searchLink><br />*<searchLink fieldCode="DE" term="%22PHAGOCYTOSIS%22">PHAGOCYTOSIS</searchLink><br />*<searchLink fieldCode="DE" term="%22HEMATOPOIESIS%22">HEMATOPOIESIS</searchLink><br />*<searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are localized around sinusoids, can (cross)-present antigens, become activated upon intravenous LPS-injection, and for the most part belong to the cDC2 subtype which is associated with Th2/Th17 immunity. Gene-expression profiling revealed that BM-resident DCs are enriched for several c-type lectins, including Dectin-1, which can bind beta-glucans expressed on fungi and yeast. Indeed, DCs in BM were much more efficient in phagocytosis of both yeast-derived zymosan-particles and Aspergillus conidiae than their splenic counterparts, which was highly dependent on Dectin-1. DCs in human BM could also phagocytose zymosan, which was dependent on β1-integrins. Moreover, zymosan-stimulated BM-resident DCs enhanced the differentiation of hematopoietic stem and progenitor cells towards neutrophils, while also boosting the maintenance of these progenitors. Our findings signify an important role for BM DCs as translators between infection and hematopoiesis, particularly in anti-fungal immunity. The ability of BM-resident DCs to boost neutrophil formation is relevant from a clinical perspective and contributes to our understanding of the increased susceptibility for fungal infections following BM damage. [ABSTRACT FROM AUTHOR]
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  Group: Ab
  Data: <i>Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/cells11010055
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: 55
    Subjects:
      – SubjectFull: BONE marrow
        Type: general
      – SubjectFull: CELL populations
        Type: general
      – SubjectFull: DENDRITIC cells
        Type: general
      – SubjectFull: HEMATOPOIETIC stem cells
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      – SubjectFull: NEUTROPHILS
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      – SubjectFull: PHAGOCYTOSIS
        Type: general
      – SubjectFull: HEMATOPOIESIS
        Type: general
      – SubjectFull: T cells
        Type: general
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      – TitleFull: Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
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              M: 01
              Text: Jan2022
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