SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia.
| Title: | SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. |
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| Authors: | Yue, Can1, Xie, Siting2, Zhong, Jiaying3, Zhao, Haijun2, Lin, Zhijuan2, Zhang, Li2, Xu, Bing2 xubingzhangjian@126.com, Luo, Yiming2 luoyimingxm@126.com |
| Source: | Scientific Reports. 8/23/2021, Vol. 11 Issue 1, p1-16. 16p. |
| Subject Terms: | *ACUTE myeloid leukemia, *MEMBRANE proteins, *PROTEIN expression, *GENETIC mutation, *MESSENGER RNA |
| Abstract: | The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. The role of SCAMPs in acute myeloid leukemia (AML), however, remains to be identified. In the present study, we explored expression patterns and prognostic value of SCAMPs and network analysis of SCAMPs-related signaling pathways in AML using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases. Genetic alteration analysis revealed that the mutation rate of SCAMP genes was below 1% (9/1272) in AML, and there was no significant correlation between SCAMPs gene mutation and AML prognosis. However, the SCAMP2/5 mRNA levels were significantly higher in AML patients than in healthy controls. Moreover, high mRNA expressions of SCAMP2/4/5 were associated with poor overall survival, which might be due to that SCAMP2/4/5 and their co-expressed genes were associated with multiple pathways related to tumorigenesis and progression, including human T-cell leukemia virus 1 infection, acute myeloid leukemia, mTOR and NF-kappa B signaling pathways. These results suggest that SCAMP2/4/5 are potential prognostic markers for AML, and that SCAMP2 and SCAMP5 individually or in combination may be used as diagnostic markers for AML. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yue%2C+Can%22">Yue, Can</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xie%2C+Siting%22">Xie, Siting</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhong%2C+Jiaying%22">Zhong, Jiaying</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Haijun%22">Zhao, Haijun</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin%2C+Zhijuan%22">Lin, Zhijuan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Li%22">Zhang, Li</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Bing%22">Xu, Bing</searchLink><relatesTo>2</relatesTo><i> xubingzhangjian@126.com</i><br /><searchLink fieldCode="AR" term="%22Luo%2C+Yiming%22">Luo, Yiming</searchLink><relatesTo>2</relatesTo><i> luoyimingxm@126.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Scientific+Reports%22">Scientific Reports</searchLink>. 8/23/2021, Vol. 11 Issue 1, p1-16. 16p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22ACUTE+myeloid+leukemia%22">ACUTE myeloid leukemia</searchLink><br />*<searchLink fieldCode="DE" term="%22MEMBRANE+proteins%22">MEMBRANE proteins</searchLink><br />*<searchLink fieldCode="DE" term="%22PROTEIN+expression%22">PROTEIN expression</searchLink><br />*<searchLink fieldCode="DE" term="%22GENETIC+mutation%22">GENETIC mutation</searchLink><br />*<searchLink fieldCode="DE" term="%22MESSENGER+RNA%22">MESSENGER RNA</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. The role of SCAMPs in acute myeloid leukemia (AML), however, remains to be identified. In the present study, we explored expression patterns and prognostic value of SCAMPs and network analysis of SCAMPs-related signaling pathways in AML using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases. Genetic alteration analysis revealed that the mutation rate of SCAMP genes was below 1% (9/1272) in AML, and there was no significant correlation between SCAMPs gene mutation and AML prognosis. However, the SCAMP2/5 mRNA levels were significantly higher in AML patients than in healthy controls. Moreover, high mRNA expressions of SCAMP2/4/5 were associated with poor overall survival, which might be due to that SCAMP2/4/5 and their co-expressed genes were associated with multiple pathways related to tumorigenesis and progression, including human T-cell leukemia virus 1 infection, acute myeloid leukemia, mTOR and NF-kappa B signaling pathways. These results suggest that SCAMP2/4/5 are potential prognostic markers for AML, and that SCAMP2 and SCAMP5 individually or in combination may be used as diagnostic markers for AML. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-021-96440-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 1 Subjects: – SubjectFull: ACUTE myeloid leukemia Type: general – SubjectFull: MEMBRANE proteins Type: general – SubjectFull: PROTEIN expression Type: general – SubjectFull: GENETIC mutation Type: general – SubjectFull: MESSENGER RNA Type: general Titles: – TitleFull: SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yue, Can – PersonEntity: Name: NameFull: Xie, Siting – PersonEntity: Name: NameFull: Zhong, Jiaying – PersonEntity: Name: NameFull: Zhao, Haijun – PersonEntity: Name: NameFull: Lin, Zhijuan – PersonEntity: Name: NameFull: Zhang, Li – PersonEntity: Name: NameFull: Xu, Bing – PersonEntity: Name: NameFull: Luo, Yiming IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 08 Text: 8/23/2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 20452322 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Scientific Reports Type: main |
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