EGR1 as a potential marker of prognosis in extranodal NK/T-cell lymphoma.
| Title: | EGR1 as a potential marker of prognosis in extranodal NK/T-cell lymphoma. |
|---|---|
| Authors: | Lee, Ji Yun1, Kim, Joo Hyun2, Bang, Heejin3, Cho, Junhun4, Ko, Young Hyeh4, Kim, Seok Jin5, Kim, Won Seog5 wskimsmc@skku.edu |
| Source: | Scientific Reports. 5/14/2021, Vol. 11 Issue 1, p1-11. 11p. |
| Subject Terms: | *EXTRANODAL NK-T-cell lymphoma, *GENE expression, *GENETIC transcription, *CHEMORECEPTORS, *CANCER prognosis |
| Abstract: | Extranodal natural killer T-cell lymphoma (ENKTL) is an aggressive malignancy with a dismal prognosis. In the present study, gene expression profiling was performed to provide more information on ENKTL molecular signature and offer a rationale for further investigation of prognostic markers in ENKTL. NanoString nCounter Analysis encompassing 133 target genes was used to compare gene expression levels of 43 ENKTL tumor samples. The majority of the patients were under 60 years of age (79.1%); 32 (74.4%) patients had nasal type ENKTL and 23 patients (53.5%) had intermediate/high risk ENKTL based on the prognostic index for natural killer cell lymphoma (PINK). The median follow-up was 15.9 months and the median overall survival (OS) was 16.1 months (95% CI 13.0–69.8). EGR1 upregulation was consistently identified in the localized stage with a low risk of prognostic index based on the PINK. Among the six significantly relevant genes for EGR1 expression, high expression levels of genes, including CD59, GAS1, CXCR7, and RAMP3, were associated with a good survival prognosis. The in vitro test showed EGR1 modulated the transcriptional activity of the target genes including CD59, GAS1, CXCR7, and RAMP3. Downregulation of EGR1 and its target genes significantly inhibited apoptosis and decreased chemosensitivity and attenuated radiation-induced apoptosis. The findings showed EGR1 may be a candidate for prognostic markers in ENKTL. Considerable additional characterization may be necessary to fully understand EGR1. [ABSTRACT FROM AUTHOR] |
| Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Academic Search Complete |
| FullText | Links: – Type: pdflink Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=20452322&ISBN=&volume=11&issue=1&date=20210514&spage=1&pages=1-11&title=Scientific Reports&atitle=EGR1%20as%20a%20potential%20marker%20of%20prognosis%20in%20extranodal%20NK%2FT-cell%20lymphoma.&aulast=Lee%2C%20Ji%20Yun&id=DOI:10.1038/s41598-021-89754-8 Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: a9h DbLabel: Academic Search Complete An: 150304123 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: EGR1 as a potential marker of prognosis in extranodal NK/T-cell lymphoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lee%2C+Ji+Yun%22">Lee, Ji Yun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Joo+Hyun%22">Kim, Joo Hyun</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bang%2C+Heejin%22">Bang, Heejin</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cho%2C+Junhun%22">Cho, Junhun</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ko%2C+Young+Hyeh%22">Ko, Young Hyeh</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Seok+Jin%22">Kim, Seok Jin</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Won+Seog%22">Kim, Won Seog</searchLink><relatesTo>5</relatesTo><i> wskimsmc@skku.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Scientific+Reports%22">Scientific Reports</searchLink>. 5/14/2021, Vol. 11 Issue 1, p1-11. 11p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22EXTRANODAL+NK-T-cell+lymphoma%22">EXTRANODAL NK-T-cell lymphoma</searchLink><br />*<searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br />*<searchLink fieldCode="DE" term="%22GENETIC+transcription%22">GENETIC transcription</searchLink><br />*<searchLink fieldCode="DE" term="%22CHEMORECEPTORS%22">CHEMORECEPTORS</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+prognosis%22">CANCER prognosis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Extranodal natural killer T-cell lymphoma (ENKTL) is an aggressive malignancy with a dismal prognosis. In the present study, gene expression profiling was performed to provide more information on ENKTL molecular signature and offer a rationale for further investigation of prognostic markers in ENKTL. NanoString nCounter Analysis encompassing 133 target genes was used to compare gene expression levels of 43 ENKTL tumor samples. The majority of the patients were under 60 years of age (79.1%); 32 (74.4%) patients had nasal type ENKTL and 23 patients (53.5%) had intermediate/high risk ENKTL based on the prognostic index for natural killer cell lymphoma (PINK). The median follow-up was 15.9 months and the median overall survival (OS) was 16.1 months (95% CI 13.0–69.8). EGR1 upregulation was consistently identified in the localized stage with a low risk of prognostic index based on the PINK. Among the six significantly relevant genes for EGR1 expression, high expression levels of genes, including CD59, GAS1, CXCR7, and RAMP3, were associated with a good survival prognosis. The in vitro test showed EGR1 modulated the transcriptional activity of the target genes including CD59, GAS1, CXCR7, and RAMP3. Downregulation of EGR1 and its target genes significantly inhibited apoptosis and decreased chemosensitivity and attenuated radiation-induced apoptosis. The findings showed EGR1 may be a candidate for prognostic markers in ENKTL. Considerable additional characterization may be necessary to fully understand EGR1. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=150304123 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-021-89754-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: EXTRANODAL NK-T-cell lymphoma Type: general – SubjectFull: GENE expression Type: general – SubjectFull: GENETIC transcription Type: general – SubjectFull: CHEMORECEPTORS Type: general – SubjectFull: CANCER prognosis Type: general Titles: – TitleFull: EGR1 as a potential marker of prognosis in extranodal NK/T-cell lymphoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lee, Ji Yun – PersonEntity: Name: NameFull: Kim, Joo Hyun – PersonEntity: Name: NameFull: Bang, Heejin – PersonEntity: Name: NameFull: Cho, Junhun – PersonEntity: Name: NameFull: Ko, Young Hyeh – PersonEntity: Name: NameFull: Kim, Seok Jin – PersonEntity: Name: NameFull: Kim, Won Seog IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 05 Text: 5/14/2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 20452322 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Scientific Reports Type: main |
| ResultId | 1 |