Academic Journal
View in EDS

Race does not predict skeletal-related events and all-cause mortality in men with castration-resistant prostate cancer.

Bibliographic Details
Title: Race does not predict skeletal-related events and all-cause mortality in men with castration-resistant prostate cancer.
Authors: Patel, Devin N.1 (AUTHOR), Howard, Lauren E.2,3 (AUTHOR), De Hoedt, Amanda M.3 (AUTHOR), Amling, Christopher L.4 (AUTHOR), Aronson, William J.5,6 (AUTHOR), Cooperberg, Matthew R.7 (AUTHOR), Kane, Christopher J.8 (AUTHOR), Klaassen, Zachary W.9,10 (AUTHOR), Terris, Martha K.9,10 (AUTHOR), Freedland, Stephen J.1,3 (AUTHOR) stephen.freedland@cshs.org
Source: Cancer (0008543X). Jul2020, Vol. 126 Issue 14, p3274-3280. 7p.
Subject Terms: *SKELETAL maturity, *SPINAL cord compression, *BONES, *PROSTATE cancer patients, *PROSTATE-specific antigen, *BONE metastasis
Abstract: Background: The impact of race on prostate cancer skeletal-related events (SREs) remains understudied. In the current study, the authors tested the impact of race on time to SREs and overall survival in men with newly diagnosed, bone metastatic castration-resistant prostate cancer (mCRPC).Methods: The authors performed a retrospective study of patients from 8 Veterans Affairs hospitals who were newly diagnosed with bone mCRPC in the year 2000 or later. SREs comprised pathologic fracture, spinal cord compression, radiotherapy to the bone, or surgery to the bone. Time from diagnosis of bone mCRPC to SREs and overall mortality was estimated using the Kaplan-Meier method. Cox models tested the association between race and SREs and overall mortality.Results: Of 837 patients with bone mCRPC, 232 patients (28%) were black and 605 (72%) were nonblack. At the time of diagnosis of bone mCRPC, black men were found to be more likely to have more bone metastases compared with nonblack men (29% vs 19% with ≥10 bone metastases; P = .021) and to have higher prostate-specific antigen (41.7 ng/mL vs 29.2 ng/mL; P = .005) and a longer time from the diagnosis of CRPC to metastasis (17.9 months vs 14.3 months; P < .01). On multivariable analysis, there were no differences noted with regard to SRE risk (hazard ratio [HR], 0.80; 95% CI, 0.59-1.07) or overall mortality (HR, 0.87; 95% CI, 0.73-1.04) between black and nonblack people, although the HRs were <1, which suggested the possibility of better outcomes.Conclusions: No significant association between black race and risk of SREs and overall mortality was observed in the current study. These data have suggested that efforts to understand the basis for the excess risk of aggressive prostate cancer in black men should focus on cancer development and progression in individuals with early-stage disease. [ABSTRACT FROM AUTHOR]
Copyright of Cancer (0008543X) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
FullText Links:
  – Type: other
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=0008543X&ISBN=&volume=126&issue=14&date=20200715&spage=3274&pages=3274-3280&title=Cancer (0008543X)&atitle=Race%20does%20not%20predict%20skeletal-related%20events%20and%20all-cause%20mortality%20in%20men%20with%20castration-resistant%20prostate%20cancer.&aulast=Patel%2C%20Devin%20N.&id=DOI:10.1002/cncr.32933
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 144237255
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Race does not predict skeletal-related events and all-cause mortality in men with castration-resistant prostate cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Patel%2C+Devin+N%2E%22&quot;&gt;Patel, Devin N.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Howard%2C+Lauren+E%2E%22&quot;&gt;Howard, Lauren E.&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22De+Hoedt%2C+Amanda+M%2E%22&quot;&gt;De Hoedt, Amanda M.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Amling%2C+Christopher+L%2E%22&quot;&gt;Amling, Christopher L.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aronson%2C+William+J%2E%22&quot;&gt;Aronson, William J.&lt;/searchLink&gt;&lt;relatesTo&gt;5,6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cooperberg%2C+Matthew+R%2E%22&quot;&gt;Cooperberg, Matthew R.&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kane%2C+Christopher+J%2E%22&quot;&gt;Kane, Christopher J.&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Klaassen%2C+Zachary+W%2E%22&quot;&gt;Klaassen, Zachary W.&lt;/searchLink&gt;&lt;relatesTo&gt;9,10&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Terris%2C+Martha+K%2E%22&quot;&gt;Terris, Martha K.&lt;/searchLink&gt;&lt;relatesTo&gt;9,10&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Freedland%2C+Stephen+J%2E%22&quot;&gt;Freedland, Stephen J.&lt;/searchLink&gt;&lt;relatesTo&gt;1,3&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; stephen.freedland@cshs.org&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Cancer+%280008543X%29%22&quot;&gt;Cancer (0008543X)&lt;/searchLink&gt;. Jul2020, Vol. 126 Issue 14, p3274-3280. 7p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SKELETAL+maturity%22&quot;&gt;SKELETAL maturity&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SPINAL+cord+compression%22&quot;&gt;SPINAL cord compression&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BONES%22&quot;&gt;BONES&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PROSTATE+cancer+patients%22&quot;&gt;PROSTATE cancer patients&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PROSTATE-specific+antigen%22&quot;&gt;PROSTATE-specific antigen&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BONE+metastasis%22&quot;&gt;BONE metastasis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Background: &lt;/bold&gt;The impact of race on prostate cancer skeletal-related events (SREs) remains understudied. In the current study, the authors tested the impact of race on time to SREs and overall survival in men with newly diagnosed, bone metastatic castration-resistant prostate cancer (mCRPC).&lt;bold&gt;Methods: &lt;/bold&gt;The authors performed a retrospective study of patients from 8 Veterans Affairs hospitals who were newly diagnosed with bone mCRPC in the year 2000 or later. SREs comprised pathologic fracture, spinal cord compression, radiotherapy to the bone, or surgery to the bone. Time from diagnosis of bone mCRPC to SREs and overall mortality was estimated using the Kaplan-Meier method. Cox models tested the association between race and SREs and overall mortality.&lt;bold&gt;Results: &lt;/bold&gt;Of 837 patients with bone mCRPC, 232 patients (28%) were black and 605 (72%) were nonblack. At the time of diagnosis of bone mCRPC, black men were found to be more likely to have more bone metastases compared with nonblack men (29% vs 19% with ≥10 bone metastases; P&#160;=&#160;.021) and to have higher prostate-specific antigen (41.7&#160;ng/mL vs 29.2&#160;ng/mL; P&#160;=&#160;.005) and a longer time from the diagnosis of CRPC to metastasis (17.9&#160;months vs 14.3&#160;months; P&#160;&lt;&#160;.01). On multivariable analysis, there were no differences noted with regard to SRE risk (hazard ratio [HR], 0.80; 95% CI, 0.59-1.07) or overall mortality (HR, 0.87; 95% CI, 0.73-1.04) between black and nonblack people, although the HRs were &lt;1, which suggested the possibility of better outcomes.&lt;bold&gt;Conclusions: &lt;/bold&gt;No significant association between black race and risk of SREs and overall mortality was observed in the current study. These data have suggested that efforts to understand the basis for the excess risk of aggressive prostate cancer in black men should focus on cancer development and progression in individuals with early-stage disease. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Cancer (0008543X) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=144237255
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/cncr.32933
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 3274
    Subjects:
      – SubjectFull: SKELETAL maturity
        Type: general
      – SubjectFull: SPINAL cord compression
        Type: general
      – SubjectFull: BONES
        Type: general
      – SubjectFull: PROSTATE cancer patients
        Type: general
      – SubjectFull: PROSTATE-specific antigen
        Type: general
      – SubjectFull: BONE metastasis
        Type: general
    Titles:
      – TitleFull: Race does not predict skeletal-related events and all-cause mortality in men with castration-resistant prostate cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Patel, Devin N.
      – PersonEntity:
          Name:
            NameFull: Howard, Lauren E.
      – PersonEntity:
          Name:
            NameFull: De Hoedt, Amanda M.
      – PersonEntity:
          Name:
            NameFull: Amling, Christopher L.
      – PersonEntity:
          Name:
            NameFull: Aronson, William J.
      – PersonEntity:
          Name:
            NameFull: Cooperberg, Matthew R.
      – PersonEntity:
          Name:
            NameFull: Kane, Christopher J.
      – PersonEntity:
          Name:
            NameFull: Klaassen, Zachary W.
      – PersonEntity:
          Name:
            NameFull: Terris, Martha K.
      – PersonEntity:
          Name:
            NameFull: Freedland, Stephen J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 07
              Text: Jul2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 0008543X
          Numbering:
            – Type: volume
              Value: 126
            – Type: issue
              Value: 14
          Titles:
            – TitleFull: Cancer (0008543X)
              Type: main
ResultId 1