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RELAțIA DINTRE BIOFILMELE BACTERIENE șI MODIFICĂRILE INFLAMATORII TISULARE LA PACIENțII CU RINOSINUZITĂ CRONICĂ.

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Title: RELAțIA DINTRE BIOFILMELE BACTERIENE șI MODIFICĂRILE INFLAMATORII TISULARE LA PACIENțII CU RINOSINUZITĂ CRONICĂ.
Alternate Title: The relationship between bacterial biofilms and inflammatory tissue changes in patients with chronic rhinosinusitis.
Authors: Duţu, Alina Gabriela1 alinagabriela.dutu@yahoo.com, Drugan, Cristina1, Drugan, Tudor C.2, Albu, Silviu3
Source: Romanian Medical Journal. 2019, Vol. 66 Issue 4, p393-399. 7p.
Subject Terms: *ASTHMA, *TOLUIDINE blue, *ENDOSCOPIC surgery, *COMORBIDITY, *BIOFILMS, *ORAL mucosa
Abstract (English): Objectives. The involvement of bacterial biofilms in the pathophysiology of chronic rhinosinusitis (CRS) is intensively debated, despite the acknowledgement of their negative impact on postoperative evolution of the disease. This study aimed to evaluate the relationship between bacterial biofilms and inflammatory infiltrate of sinus mucosa, and the influence of comorbidities on biofilm development. Materials and methods. The study comprised 50 CRS patients, treated by endoscopic surgery. For biofilm identification and inflammatory infiltrate evaluation, sinus mucosa samples were taken during surgical intervention and studied by haematoxylin-eosin and toluidine blue staining. Results. Biofilms were present in 34 patients (68%). Among them, 22 patients displayed an abundant inflammatory infiltrate of the sinus mucosa, this association being statistically significant (p < 0.001). Biofilm development was also significantly associated with the following comorbidities: bronchial asthma (p = 0.006) and atopic background (p < 0.001). Conclusions. Bacterial biofilms were significantly associated with an abundant inflammatory infiltrate of the sinus mucosa, demonstrating an intensive local inflammatory response. Among the comorbidities frequently associated with CRS, bronchial asthma and atopic background proved a significant increase in the odds of biofilm development. [ABSTRACT FROM AUTHOR]
Abstract (Romanian): Obiective. În fiziopatologia rinosinuzitei cronice (RSC), rolul biofilmelor microbiene este intens dezbătut, acestea reprezentând un potențial factor de prognostic defavorabil în evoluția postoperatorie a RSC. În acest studiu, ne-am propus să analizăm relația dintre prezența biofilmelor și infiltratul inflamator al mucoasei rinosinusale, precum și impactul comorbidităților asupra dezvoltării biofilmelor la pacienții cu RSC. Material şi metode. Studiul a inclus un total de 50 de pacienți cu RSC, tratați chirurgical prin intervenție endoscopică. Probele de mucoasă sinusală prelevate în timpul operației au fost studiate prin colorație cu hematoxilină- eozină și albastru de toluidină pentru identificarea biofilmelor şi evaluarea infiltratului inflamator. Rezultate. Biofilmele au fost prezente la 34 dintre cei 50 de pacienți (68%). Analiza inflamației tisulare a arătat că 22 de pacienți dintre cei 34 cu biofilme bacteriene au prezentat un infiltrat inflamator abundent la nivelul mucoasei sinusale, această asociere fiind semnificativă din punct de vedere statistic (p < 0,001). Prezența biofilmelor a fost, de asemenea, semnificativ asociată cu următoarele comorbidități: astmul bronșic (p = 0,006) și terenul alergic (p < 0,001). Concluzii. Prezența biofilmelor s-a corelat semnificativ cu un infiltrat inflamator abundent, demonstrând amplificarea răspunsului inflamator local. Dintre comorbiditățile asociate frecvent cu RSC, astmul bronșic și terenul alergic au arătat o creștere semnificativă a șanselor de apariție a biofilmelor. [ABSTRACT FROM AUTHOR]
Copyright of Romanian Medical Journal is the property of Amaltea Medical Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: RELAțIA DINTRE BIOFILMELE BACTERIENE șI MODIFICĂRILE INFLAMATORII TISULARE LA PACIENțII CU RINOSINUZITĂ CRONICĂ.
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  Data: The relationship between bacterial biofilms and inflammatory tissue changes in patients with chronic rhinosinusitis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Duţu%2C+Alina+Gabriela%22&quot;&gt;Duţu, Alina Gabriela&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; alinagabriela.dutu@yahoo.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Drugan%2C+Cristina%22&quot;&gt;Drugan, Cristina&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Drugan%2C+Tudor+C%2E%22&quot;&gt;Drugan, Tudor C.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Albu%2C+Silviu%22&quot;&gt;Albu, Silviu&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Romanian+Medical+Journal%22&quot;&gt;Romanian Medical Journal&lt;/searchLink&gt;. 2019, Vol. 66 Issue 4, p393-399. 7p.
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  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ASTHMA%22&quot;&gt;ASTHMA&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TOLUIDINE+blue%22&quot;&gt;TOLUIDINE blue&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ENDOSCOPIC+surgery%22&quot;&gt;ENDOSCOPIC surgery&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22COMORBIDITY%22&quot;&gt;COMORBIDITY&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BIOFILMS%22&quot;&gt;BIOFILMS&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ORAL+mucosa%22&quot;&gt;ORAL mucosa&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objectives. The involvement of bacterial biofilms in the pathophysiology of chronic rhinosinusitis (CRS) is intensively debated, despite the acknowledgement of their negative impact on postoperative evolution of the disease. This study aimed to evaluate the relationship between bacterial biofilms and inflammatory infiltrate of sinus mucosa, and the influence of comorbidities on biofilm development. Materials and methods. The study comprised 50 CRS patients, treated by endoscopic surgery. For biofilm identification and inflammatory infiltrate evaluation, sinus mucosa samples were taken during surgical intervention and studied by haematoxylin-eosin and toluidine blue staining. Results. Biofilms were present in 34 patients (68%). Among them, 22 patients displayed an abundant inflammatory infiltrate of the sinus mucosa, this association being statistically significant (p &lt; 0.001). Biofilm development was also significantly associated with the following comorbidities: bronchial asthma (p = 0.006) and atopic background (p &lt; 0.001). Conclusions. Bacterial biofilms were significantly associated with an abundant inflammatory infiltrate of the sinus mucosa, demonstrating an intensive local inflammatory response. Among the comorbidities frequently associated with CRS, bronchial asthma and atopic background proved a significant increase in the odds of biofilm development. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Romanian)
  Group: Ab
  Data: Obiective. &#206;n fiziopatologia rinosinuzitei cronice (RSC), rolul biofilmelor microbiene este intens dezbătut, acestea reprezent&#226;nd un potențial factor de prognostic defavorabil &#238;n evoluția postoperatorie a RSC. &#206;n acest studiu, ne-am propus să analizăm relația dintre prezența biofilmelor și infiltratul inflamator al mucoasei rinosinusale, precum și impactul comorbidităților asupra dezvoltării biofilmelor la pacienții cu RSC. Material şi metode. Studiul a inclus un total de 50 de pacienți cu RSC, tratați chirurgical prin intervenție endoscopică. Probele de mucoasă sinusală prelevate &#238;n timpul operației au fost studiate prin colorație cu hematoxilină- eozină și albastru de toluidină pentru identificarea biofilmelor şi evaluarea infiltratului inflamator. Rezultate. Biofilmele au fost prezente la 34 dintre cei 50 de pacienți (68%). Analiza inflamației tisulare a arătat că 22 de pacienți dintre cei 34 cu biofilme bacteriene au prezentat un infiltrat inflamator abundent la nivelul mucoasei sinusale, această asociere fiind semnificativă din punct de vedere statistic (p &lt; 0,001). Prezența biofilmelor a fost, de asemenea, semnificativ asociată cu următoarele comorbidități: astmul bronșic (p = 0,006) și terenul alergic (p &lt; 0,001). Concluzii. Prezența biofilmelor s-a corelat semnificativ cu un infiltrat inflamator abundent, demonstr&#226;nd amplificarea răspunsului inflamator local. Dintre comorbiditățile asociate frecvent cu RSC, astmul bronșic și terenul alergic au arătat o creștere semnificativă a șanselor de apariție a biofilmelor. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Romanian Medical Journal is the property of Amaltea Medical Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.37897/rmj.2019.4.18
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        Text: Romanian
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      – SubjectFull: ENDOSCOPIC surgery
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      – TitleFull: RELAțIA DINTRE BIOFILMELE BACTERIENE șI MODIFICĂRILE INFLAMATORII TISULARE LA PACIENțII CU RINOSINUZITĂ CRONICĂ.
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