In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of Clematis viticella L.
| Title: | In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of Clematis viticella L. |
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| Authors: | ACAR-ŞAH, Esra1, CELEP, Engin2 ecelep@yeditepe.edu.tr, YEŞİLADA, Erdem2 |
| Source: | Journal of Research in Pharmacy. 2019, Vol. 23 Issue 2, p326-335. 10p. |
| Subject Terms: | *CLEMATIS, *ANTIOXIDANTS, *PHYTOCHEMICALS, *BIOAVAILABILITY, *BIOTRANSFORMATION (Metabolism) |
| Abstract: | Since biotransformation processes generally affect the biological activities of phytochemical compounds, bioavailability is one of the primary steps in determining the potency of the activity. Previous studies have shown that in vitro antioxidant capacity of phytochemicals cannot completely reflect real health benefits. Clematis species (Ranunculaceae) are used to eliminate the symptoms of many diseases including particularly in the treatment of rheumatic diseases in Turkey, however the number of studies conducted is limited. In the light of this information, the total phytochemical profile of the extract of aerial parts of C. viticella prepared with 80% methanol and the gastrointestinal digestion products and the antioxidant activity profile were evaluated by subjecting them to the in vitro simulation model of the human digestive tract in the study. It was observed that both total phytochemical content and antioxidant activity decreased after simulated human digestion. Moreover, this study was shown potential bioaccessibility and bioavailability of total phenol, phenolic acid, flavonoid, and saponin content found in the aerial parts of Clematis viticella were reduced. Consequently, these indicate that it can result from the complicated interaction of compounds in the plant matrix in an in vitro simulated human digestion. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of Clematis viticella L. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22ACAR-ŞAH%2C+Esra%22">ACAR-ŞAH, Esra</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22CELEP%2C+Engin%22">CELEP, Engin</searchLink><relatesTo>2</relatesTo><i> ecelep@yeditepe.edu.tr</i><br /><searchLink fieldCode="AR" term="%22YEŞİLADA%2C+Erdem%22">YEŞİLADA, Erdem</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Research+in+Pharmacy%22">Journal of Research in Pharmacy</searchLink>. 2019, Vol. 23 Issue 2, p326-335. 10p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22CLEMATIS%22">CLEMATIS</searchLink><br />*<searchLink fieldCode="DE" term="%22ANTIOXIDANTS%22">ANTIOXIDANTS</searchLink><br />*<searchLink fieldCode="DE" term="%22PHYTOCHEMICALS%22">PHYTOCHEMICALS</searchLink><br />*<searchLink fieldCode="DE" term="%22BIOAVAILABILITY%22">BIOAVAILABILITY</searchLink><br />*<searchLink fieldCode="DE" term="%22BIOTRANSFORMATION+%28Metabolism%29%22">BIOTRANSFORMATION (Metabolism)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Since biotransformation processes generally affect the biological activities of phytochemical compounds, bioavailability is one of the primary steps in determining the potency of the activity. Previous studies have shown that in vitro antioxidant capacity of phytochemicals cannot completely reflect real health benefits. Clematis species (Ranunculaceae) are used to eliminate the symptoms of many diseases including particularly in the treatment of rheumatic diseases in Turkey, however the number of studies conducted is limited. In the light of this information, the total phytochemical profile of the extract of aerial parts of C. viticella prepared with 80% methanol and the gastrointestinal digestion products and the antioxidant activity profile were evaluated by subjecting them to the in vitro simulation model of the human digestive tract in the study. It was observed that both total phytochemical content and antioxidant activity decreased after simulated human digestion. Moreover, this study was shown potential bioaccessibility and bioavailability of total phenol, phenolic acid, flavonoid, and saponin content found in the aerial parts of Clematis viticella were reduced. Consequently, these indicate that it can result from the complicated interaction of compounds in the plant matrix in an in vitro simulated human digestion. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Research in Pharmacy is the property of Marmara University, Faculty of Pharmacy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.12991/jrp.2019.140 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 326 Subjects: – SubjectFull: CLEMATIS Type: general – SubjectFull: ANTIOXIDANTS Type: general – SubjectFull: PHYTOCHEMICALS Type: general – SubjectFull: BIOAVAILABILITY Type: general – SubjectFull: BIOTRANSFORMATION (Metabolism) Type: general Titles: – TitleFull: In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of Clematis viticella L. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: ACAR-ŞAH, Esra – PersonEntity: Name: NameFull: CELEP, Engin – PersonEntity: Name: NameFull: YEŞİLADA, Erdem IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 26306344 Numbering: – Type: volume Value: 23 – Type: issue Value: 2 Titles: – TitleFull: Journal of Research in Pharmacy Type: main |
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