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MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia.

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Title: MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia.
Authors: Trino, Stefania1 stefania.trino@gmail.com, Lamorte, Daniela1, Caivano, Antonella1, Laurenzana, Ilaria1, Tagliaferri, Daniela2 daniela.tagliaferri11@gmail.com, Falco, Geppino2,3, Del Vecchio, Luigi4,5 luigi.delvecchio@unina.it, Musto, Pellegrino6 pellegrino.musto@crob.it, De Luca, Luciana1 dr.luciana.deluca@gmail.com
Source: International Journal of Molecular Sciences. Feb2018, Vol. 19 Issue 2, p460. 25p.
Subject Terms: *MICRORNA, *BIOLOGICAL tags, *ACUTE myeloid leukemia treatment, *ACUTE myeloid leukemia diagnosis, *PROGENITOR cells, *THERAPEUTICS
Abstract: Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical features. Among the genetic aberrations that control disease development there are microRNAs (miRNAs). miRNAs are small non-coding RNAs that regulate, at post-transcriptional level, translation and stability of mRNAs. It is now established that deregulated miRNA expression is a prominent feature in AML. Functional studies have shown that miRNAs play an important role in AML pathogenesis and miRNA expression signatures are associated with chemotherapy response and clinical outcome. In this review we summarized miRNA signature in AML with different cytogenetic, molecular and clinical characteristics. Moreover, we reviewed the miRNA regulatory network in AML pathogenesis and we discussed the potential use of cellular and circulating miRNAs as biomarkers for diagnosis and prognosis and as therapeutic targets. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia.
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  Data: <searchLink fieldCode="AR" term="%22Trino%2C+Stefania%22">Trino, Stefania</searchLink><relatesTo>1</relatesTo><i> stefania.trino@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Lamorte%2C+Daniela%22">Lamorte, Daniela</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Caivano%2C+Antonella%22">Caivano, Antonella</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Laurenzana%2C+Ilaria%22">Laurenzana, Ilaria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tagliaferri%2C+Daniela%22">Tagliaferri, Daniela</searchLink><relatesTo>2</relatesTo><i> daniela.tagliaferri11@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Falco%2C+Geppino%22">Falco, Geppino</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Del+Vecchio%2C+Luigi%22">Del Vecchio, Luigi</searchLink><relatesTo>4,5</relatesTo><i> luigi.delvecchio@unina.it</i><br /><searchLink fieldCode="AR" term="%22Musto%2C+Pellegrino%22">Musto, Pellegrino</searchLink><relatesTo>6</relatesTo><i> pellegrino.musto@crob.it</i><br /><searchLink fieldCode="AR" term="%22De+Luca%2C+Luciana%22">De Luca, Luciana</searchLink><relatesTo>1</relatesTo><i> dr.luciana.deluca@gmail.com</i>
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  Data: Acute myeloid leukemias (AML) are clonal disorders of hematopoietic progenitor cells which are characterized by relevant heterogeneity in terms of phenotypic, genotypic, and clinical features. Among the genetic aberrations that control disease development there are microRNAs (miRNAs). miRNAs are small non-coding RNAs that regulate, at post-transcriptional level, translation and stability of mRNAs. It is now established that deregulated miRNA expression is a prominent feature in AML. Functional studies have shown that miRNAs play an important role in AML pathogenesis and miRNA expression signatures are associated with chemotherapy response and clinical outcome. In this review we summarized miRNA signature in AML with different cytogenetic, molecular and clinical characteristics. Moreover, we reviewed the miRNA regulatory network in AML pathogenesis and we discussed the potential use of cellular and circulating miRNAs as biomarkers for diagnosis and prognosis and as therapeutic targets. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Feb2018
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