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In Vivo Retinal Vein Bypass Surgery in a Porcine Model.

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Title: In Vivo Retinal Vein Bypass Surgery in a Porcine Model.
Authors: Shen, Li-Jun1,2 (AUTHOR), Chen, Yi-Qi2 (AUTHOR), Cheng, Dan2 (AUTHOR), Zhang, Chaote2 (AUTHOR), Jiang, Lu2 (AUTHOR), Hong, Mingsheng2 (AUTHOR), Kang, Qian-Yan1 (AUTHOR) kangqy@mail.xjtu.edu.cn
Source: Current Eye Research. Jan2016, Vol. 41 Issue 1, p79-87. 9p.
Subject Terms: *TREATMENT of embolisms, *RETINAL vein, *LABORATORY swine, *RETINAL angiography, *ASPIRIN, *WARFARIN, *DRUG therapy
Abstract: Purpose: To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. Methods: Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous detachment. Aspirin and warfarin were oral administered daily starting 5 d prior to vascular surgery for anti-coagulation. The minipigs were anethetized with an intraperitoneal injection of 300 mg/kg chloral hydrate for intravitreal injection procedure and vascular surgery. Temporary keratoprosthesis vitrectomy was performed, and intraoperative video fluorescein angiography (VFA) was possible. The central and posterior vitreous was removed together with the posterior hyaloid membrane to facilitate vascular maneuvers. BRVO was induced by bipolar diathermy on the vein at the main vein’s first branching. Polyimide tubes (50.8-μm internal diameter and 7.6-μm wall thickness) were used as artificial vessels. Vascular manipulation was performed in a bimanual manner. Both end of a prepared tubing was inserted into venous lumen by puncturing and catheterization, and the vein bypass bridging the occlusion was created. Then, the patency of the bypass graft was assessed by intraoperative VFA. Results: The retinal vein bypass surgery was surgically accomplished in 33% (5/15) of the eyes, and the immediate graft patency was confirmed by intraoperative VFA only in one eye. We observed and recorded fluorescein flow from the branch vein to the main vein through the bypass graft which bridging the occlusive vein segment. Conclusions: We demonstrated the feasibility of retinal vein bypass for induced BRVO in the living porcine eye, and the immediate graft patency was successfully evaluated by intraoperative VFA. Despite the potential, there are still some significant hurdlesin vivoretinal vein bypass surgery, and modification of both surgical instruments and maneuvers is needed for further study. [ABSTRACT FROM PUBLISHER]
Copyright of Current Eye Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: In Vivo Retinal Vein Bypass Surgery in a Porcine Model.
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  Data: <searchLink fieldCode="AR" term="%22Shen%2C+Li-Jun%22">Shen, Li-Jun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yi-Qi%22">Chen, Yi-Qi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Dan%22">Cheng, Dan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Chaote%22">Zhang, Chaote</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Lu%22">Jiang, Lu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hong%2C+Mingsheng%22">Hong, Mingsheng</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang%2C+Qian-Yan%22">Kang, Qian-Yan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> kangqy@mail.xjtu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Current+Eye+Research%22">Current Eye Research</searchLink>. Jan2016, Vol. 41 Issue 1, p79-87. 9p.
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  Data: *<searchLink fieldCode="DE" term="%22TREATMENT+of+embolisms%22">TREATMENT of embolisms</searchLink><br />*<searchLink fieldCode="DE" term="%22RETINAL+vein%22">RETINAL vein</searchLink><br />*<searchLink fieldCode="DE" term="%22LABORATORY+swine%22">LABORATORY swine</searchLink><br />*<searchLink fieldCode="DE" term="%22RETINAL+angiography%22">RETINAL angiography</searchLink><br />*<searchLink fieldCode="DE" term="%22ASPIRIN%22">ASPIRIN</searchLink><br />*<searchLink fieldCode="DE" term="%22WARFARIN%22">WARFARIN</searchLink><br />*<searchLink fieldCode="DE" term="%22DRUG+therapy%22">DRUG therapy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. Methods: Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous detachment. Aspirin and warfarin were oral administered daily starting 5 d prior to vascular surgery for anti-coagulation. The minipigs were anethetized with an intraperitoneal injection of 300 mg/kg chloral hydrate for intravitreal injection procedure and vascular surgery. Temporary keratoprosthesis vitrectomy was performed, and intraoperative video fluorescein angiography (VFA) was possible. The central and posterior vitreous was removed together with the posterior hyaloid membrane to facilitate vascular maneuvers. BRVO was induced by bipolar diathermy on the vein at the main vein’s first branching. Polyimide tubes (50.8-μm internal diameter and 7.6-μm wall thickness) were used as artificial vessels. Vascular manipulation was performed in a bimanual manner. Both end of a prepared tubing was inserted into venous lumen by puncturing and catheterization, and the vein bypass bridging the occlusion was created. Then, the patency of the bypass graft was assessed by intraoperative VFA. Results: The retinal vein bypass surgery was surgically accomplished in 33% (5/15) of the eyes, and the immediate graft patency was confirmed by intraoperative VFA only in one eye. We observed and recorded fluorescein flow from the branch vein to the main vein through the bypass graft which bridging the occlusive vein segment. Conclusions: We demonstrated the feasibility of retinal vein bypass for induced BRVO in the living porcine eye, and the immediate graft patency was successfully evaluated by intraoperative VFA. Despite the potential, there are still some significant hurdlesin vivoretinal vein bypass surgery, and modification of both surgical instruments and maneuvers is needed for further study. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Current Eye Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3109/02713683.2014.997887
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      – Code: eng
        Text: English
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        PageCount: 9
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      – SubjectFull: TREATMENT of embolisms
        Type: general
      – SubjectFull: RETINAL vein
        Type: general
      – SubjectFull: LABORATORY swine
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      – SubjectFull: RETINAL angiography
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      – TitleFull: In Vivo Retinal Vein Bypass Surgery in a Porcine Model.
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            NameFull: Shen, Li-Jun
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              Text: Jan2016
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