Treatment and survival analyses of completely resected thymic carcinoma patients.
| Title: | Treatment and survival analyses of completely resected thymic carcinoma patients. |
|---|---|
| Authors: | Yanjiao Mao1, Shixiu Wu1 wushixiuhangzhou@163.com |
| Source: | OncoTargets & Therapy. Sep2015, Vol. 8, p2503-2506. 4p. |
| Subject Terms: | *THYMUS cancer, *THYMUS surgery, *CANCER treatment, *SURGICAL excision, *CANCER radiotherapy, *CANCER chemotherapy |
| Abstract: | Purpose: To investigate the impact of chemotherapy and/or radiotherapy on disease-free survival (DFS) and overall survival (OS) rates of patients with thymic carcinoma after complete resection. Methods: Between 2001 and 2013, 54 patients with complete resection of thymic carcinoma in Hangzhou Cancer Hospital were retrospectively reviewed. The Kaplan-Meier method was used to evaluate the survival rates. The Cox proportional hazard model was used for multivariate analysis. Results: Among the 54 patients, Masaoka stage I was observed in seven patients, II in 22 patients, and III in 25 patients. Sixteen patients received adjuvant chemotherapy (six with chemotherapy alone and ten with radiotherapy and chemotherapy), 25 patients received adjuvant radiotherapy, and 13 patients did not receive radiotherapy and/or chemotherapy. The 5-year DFS and OS rates for all patients were 63.0% and 73.4%, respectively. Univariate analysis revealed that radiotherapy was significantly associated with DFS and OS (P=0.014 and P=0.029, respectively), while adjuvant chemotherapy was not (P=0.122 and P=0.373, respectively). Multivariate analysis showed that adjuvant radiotherapy increased DFS (P=0.041), but not OS (P=0.051). Conclusion: Complete resection followed by adjuvant radiotherapy increased disease-free rates of thymic carcinoma patients. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Treatment and survival analyses of completely resected thymic carcinoma patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yanjiao+Mao%22">Yanjiao Mao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shixiu+Wu%22">Shixiu Wu</searchLink><relatesTo>1</relatesTo><i> wushixiuhangzhou@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22OncoTargets+%26+Therapy%22">OncoTargets & Therapy</searchLink>. Sep2015, Vol. 8, p2503-2506. 4p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22THYMUS+cancer%22">THYMUS cancer</searchLink><br />*<searchLink fieldCode="DE" term="%22THYMUS+surgery%22">THYMUS surgery</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+treatment%22">CANCER treatment</searchLink><br />*<searchLink fieldCode="DE" term="%22SURGICAL+excision%22">SURGICAL excision</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+radiotherapy%22">CANCER radiotherapy</searchLink><br />*<searchLink fieldCode="DE" term="%22CANCER+chemotherapy%22">CANCER chemotherapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To investigate the impact of chemotherapy and/or radiotherapy on disease-free survival (DFS) and overall survival (OS) rates of patients with thymic carcinoma after complete resection. Methods: Between 2001 and 2013, 54 patients with complete resection of thymic carcinoma in Hangzhou Cancer Hospital were retrospectively reviewed. The Kaplan-Meier method was used to evaluate the survival rates. The Cox proportional hazard model was used for multivariate analysis. Results: Among the 54 patients, Masaoka stage I was observed in seven patients, II in 22 patients, and III in 25 patients. Sixteen patients received adjuvant chemotherapy (six with chemotherapy alone and ten with radiotherapy and chemotherapy), 25 patients received adjuvant radiotherapy, and 13 patients did not receive radiotherapy and/or chemotherapy. The 5-year DFS and OS rates for all patients were 63.0% and 73.4%, respectively. Univariate analysis revealed that radiotherapy was significantly associated with DFS and OS (P=0.014 and P=0.029, respectively), while adjuvant chemotherapy was not (P=0.122 and P=0.373, respectively). Multivariate analysis showed that adjuvant radiotherapy increased DFS (P=0.041), but not OS (P=0.051). Conclusion: Complete resection followed by adjuvant radiotherapy increased disease-free rates of thymic carcinoma patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of OncoTargets & Therapy is the property of Dove Medical Press Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.2147/OTT.S87222 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 2503 Subjects: – SubjectFull: THYMUS cancer Type: general – SubjectFull: THYMUS surgery Type: general – SubjectFull: CANCER treatment Type: general – SubjectFull: SURGICAL excision Type: general – SubjectFull: CANCER radiotherapy Type: general – SubjectFull: CANCER chemotherapy Type: general Titles: – TitleFull: Treatment and survival analyses of completely resected thymic carcinoma patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yanjiao Mao – PersonEntity: Name: NameFull: Shixiu Wu IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 11786930 Numbering: – Type: volume Value: 8 Titles: – TitleFull: OncoTargets & Therapy Type: main |
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