Academic Journal
View in EDS
HTML Full Text

Incidence and early outcomes associated with pre-transplant antivimentin antibodies in the cardiac transplantation population.

Bibliographic Details
Title: Incidence and early outcomes associated with pre-transplant antivimentin antibodies in the cardiac transplantation population.
Authors: Young, Raymond K.1, Dale, Bethany2, Russell, Stuart D.1, Zachary, Andrea A.2, Tedford, Ryan J.1
Source: Clinical Transplantation. Aug2015, Vol. 29 Issue 8, p685-688. 4p.
Subject Terms: *HEALTH outcome assessment, *VIMENTIN, *HEART transplantation, *IMMUNOGLOBULINS, *ENDOTHELIAL cells
Abstract: Background In cardiac transplant recipients, the development of antibodies to the endothelial intermediate filament protein vimentin (antivimentin antibodies, AVA) has been associated with rejection and poor outcomes. However, the incidence of these antibodies prior to transplantation and their association with early rejection has not been investigated. Methods Pre-transplant serum was analyzed from 50 patients who underwent de novo cardiac transplant at Johns Hopkins Hospital from 2004 to 2012. Demographic, one-yr rejection, and survival data were obtained from the transplant database. Results The incidence of pre-transplant AVA was 34%. AVA-positive patients were younger (p = 0.03), and there was an a trend toward incidence in females (p = 0.08). Demographic data were similar among both groups. AVA positivity did not predict rejection in the first year post-transplant. There was no difference in rejection-free graft survival (53 vs. 52%, p = 0.85) at one yr. Similarly, there was no difference in graft survival at one yr (82 vs. 88%, p = 0.56) or graft survival at a median follow-up of 23 and 26 months, respectively (76 vs. 85%, p = 0.41). Conclusions AVA is common in the cardiac pre-transplant population with a higher incidence in the young. The presence of detectable AVA did not correlate with early post-transplant rejection or graft survival. [ABSTRACT FROM AUTHOR]
Copyright of Clinical Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=09020063&ISBN=&volume=29&issue=8&date=20150801&spage=685&pages=685-688&title=Clinical Transplantation&atitle=Incidence%20and%20early%20outcomes%20associated%20with%20pre-transplant%20antivimentin%20antibodies%20in%20the%20cardiac%20transplantation%20population.&aulast=Young%2C%20Raymond%20K.&id=DOI:10.1111/ctr.12567
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 108442549
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Incidence and early outcomes associated with pre-transplant antivimentin antibodies in the cardiac transplantation population.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Young%2C+Raymond+K%2E%22">Young, Raymond K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dale%2C+Bethany%22">Dale, Bethany</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Russell%2C+Stuart+D%2E%22">Russell, Stuart D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zachary%2C+Andrea+A%2E%22">Zachary, Andrea A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tedford%2C+Ryan+J%2E%22">Tedford, Ryan J.</searchLink><relatesTo>1</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Clinical+Transplantation%22">Clinical Transplantation</searchLink>. Aug2015, Vol. 29 Issue 8, p685-688. 4p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22HEALTH+outcome+assessment%22">HEALTH outcome assessment</searchLink><br />*<searchLink fieldCode="DE" term="%22VIMENTIN%22">VIMENTIN</searchLink><br />*<searchLink fieldCode="DE" term="%22HEART+transplantation%22">HEART transplantation</searchLink><br />*<searchLink fieldCode="DE" term="%22IMMUNOGLOBULINS%22">IMMUNOGLOBULINS</searchLink><br />*<searchLink fieldCode="DE" term="%22ENDOTHELIAL+cells%22">ENDOTHELIAL cells</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background In cardiac transplant recipients, the development of antibodies to the endothelial intermediate filament protein vimentin (antivimentin antibodies, AVA) has been associated with rejection and poor outcomes. However, the incidence of these antibodies prior to transplantation and their association with early rejection has not been investigated. Methods Pre-transplant serum was analyzed from 50 patients who underwent de novo cardiac transplant at Johns Hopkins Hospital from 2004 to 2012. Demographic, one-yr rejection, and survival data were obtained from the transplant database. Results The incidence of pre-transplant AVA was 34%. AVA-positive patients were younger (p = 0.03), and there was an a trend toward incidence in females (p = 0.08). Demographic data were similar among both groups. AVA positivity did not predict rejection in the first year post-transplant. There was no difference in rejection-free graft survival (53 vs. 52%, p = 0.85) at one yr. Similarly, there was no difference in graft survival at one yr (82 vs. 88%, p = 0.56) or graft survival at a median follow-up of 23 and 26 months, respectively (76 vs. 85%, p = 0.41). Conclusions AVA is common in the cardiac pre-transplant population with a higher incidence in the young. The presence of detectable AVA did not correlate with early post-transplant rejection or graft survival. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Clinical Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=108442549
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ctr.12567
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 685
    Subjects:
      – SubjectFull: HEALTH outcome assessment
        Type: general
      – SubjectFull: VIMENTIN
        Type: general
      – SubjectFull: HEART transplantation
        Type: general
      – SubjectFull: IMMUNOGLOBULINS
        Type: general
      – SubjectFull: ENDOTHELIAL cells
        Type: general
    Titles:
      – TitleFull: Incidence and early outcomes associated with pre-transplant antivimentin antibodies in the cardiac transplantation population.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Young, Raymond K.
      – PersonEntity:
          Name:
            NameFull: Dale, Bethany
      – PersonEntity:
          Name:
            NameFull: Russell, Stuart D.
      – PersonEntity:
          Name:
            NameFull: Zachary, Andrea A.
      – PersonEntity:
          Name:
            NameFull: Tedford, Ryan J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 09020063
          Numbering:
            – Type: volume
              Value: 29
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Clinical Transplantation
              Type: main
ResultId 1