Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study.
| Title: | Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study. |
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| Authors: | de Cock, Marijke1 m.de.cock@vu.nl, de Boer, Michiel R.1 m.r.de.boer@vu.nl, Lamoree, Marja2 marja.lamoree@vu.nl, Legler, Juliette2 juliette.legler@vu.nl, van de Bor, Margot1 m.vande.bor@vu.nl |
| Source: | Environmental Health: A Global Access Science Source. 2014, Vol. 13 Issue 1, p88-108. 21p. 5 Charts. |
| Subject Terms: | *ENDOCRINE disruptors, *THYROID hormones, *NEURAL development, *THYROXINE, *HEXACHLOROBENZENE, *PHYSIOLOGY |
| Abstract: | Background Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limited, however as the presence of chemicals in the environment is ubiquitous, further research is warranted. The objective of the current study was to assess the association between exposure markers of various EDCs and thyroxine (T4) levels in newborns in a mother-child cohort in the Netherlands. Methods Exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, hexachlorobenzene (HCB), polychlorinated biphenyl (PCB)-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma or breast milk, and information on T4 levels in heel prick blood spots was obtained through the neonatal screening programme in the Netherlands. Linear regression models were composed to determine associations between each of the compounds and T4, which were stratified for gender and adjusted for a priori defined covariates. Results Mean T4 level was 86.9 nmol/L (n = 83). Girls in the highest quartile of DDE and PFOA exposure showed an increased T4 level compared to the lowest quartile with both crude and fully adjusted models (DDE > 107.50 ng/L, +24.8 nmol/L, 95% CI 0.79, 48.75; PFOA > 1200 ng/L, +38.6 nmol/L, 95% CI 13.34, 63.83). In boys a lower T4 level was seen in the second quartile of exposure for both PFOS and PFOA, however after fully adjusting the models these associations were attenuated. No effects were observed for the other compounds. Conclusion DDE and perfluorinated alkyl acids may be associated with T4 in a sex-specific manner. These results should however be interpreted with caution, due to the relatively small study population. More research is warranted, as studies on the role of environmental contaminants in this area are still limited. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22de+Cock%2C+Marijke%22">de Cock, Marijke</searchLink><relatesTo>1</relatesTo><i> m.de.cock@vu.nl</i><br /><searchLink fieldCode="AR" term="%22de+Boer%2C+Michiel+R%2E%22">de Boer, Michiel R.</searchLink><relatesTo>1</relatesTo><i> m.r.de.boer@vu.nl</i><br /><searchLink fieldCode="AR" term="%22Lamoree%2C+Marja%22">Lamoree, Marja</searchLink><relatesTo>2</relatesTo><i> marja.lamoree@vu.nl</i><br /><searchLink fieldCode="AR" term="%22Legler%2C+Juliette%22">Legler, Juliette</searchLink><relatesTo>2</relatesTo><i> juliette.legler@vu.nl</i><br /><searchLink fieldCode="AR" term="%22van+de+Bor%2C+Margot%22">van de Bor, Margot</searchLink><relatesTo>1</relatesTo><i> m.vande.bor@vu.nl</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health%3A+A+Global+Access+Science+Source%22">Environmental Health: A Global Access Science Source</searchLink>. 2014, Vol. 13 Issue 1, p88-108. 21p. 5 Charts. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22ENDOCRINE+disruptors%22">ENDOCRINE disruptors</searchLink><br />*<searchLink fieldCode="DE" term="%22THYROID+hormones%22">THYROID hormones</searchLink><br />*<searchLink fieldCode="DE" term="%22NEURAL+development%22">NEURAL development</searchLink><br />*<searchLink fieldCode="DE" term="%22THYROXINE%22">THYROXINE</searchLink><br />*<searchLink fieldCode="DE" term="%22HEXACHLOROBENZENE%22">HEXACHLOROBENZENE</searchLink><br />*<searchLink fieldCode="DE" term="%22PHYSIOLOGY%22">PHYSIOLOGY</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limited, however as the presence of chemicals in the environment is ubiquitous, further research is warranted. The objective of the current study was to assess the association between exposure markers of various EDCs and thyroxine (T4) levels in newborns in a mother-child cohort in the Netherlands. Methods Exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, hexachlorobenzene (HCB), polychlorinated biphenyl (PCB)-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma or breast milk, and information on T4 levels in heel prick blood spots was obtained through the neonatal screening programme in the Netherlands. Linear regression models were composed to determine associations between each of the compounds and T4, which were stratified for gender and adjusted for a priori defined covariates. Results Mean T4 level was 86.9 nmol/L (n = 83). Girls in the highest quartile of DDE and PFOA exposure showed an increased T4 level compared to the lowest quartile with both crude and fully adjusted models (DDE > 107.50 ng/L, +24.8 nmol/L, 95% CI 0.79, 48.75; PFOA > 1200 ng/L, +38.6 nmol/L, 95% CI 13.34, 63.83). In boys a lower T4 level was seen in the second quartile of exposure for both PFOS and PFOA, however after fully adjusting the models these associations were attenuated. No effects were observed for the other compounds. Conclusion DDE and perfluorinated alkyl acids may be associated with T4 in a sex-specific manner. These results should however be interpreted with caution, due to the relatively small study population. More research is warranted, as studies on the role of environmental contaminants in this area are still limited. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/1476-069X-13-106 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 21 StartPage: 88 Subjects: – SubjectFull: ENDOCRINE disruptors Type: general – SubjectFull: THYROID hormones Type: general – SubjectFull: NEURAL development Type: general – SubjectFull: THYROXINE Type: general – SubjectFull: HEXACHLOROBENZENE Type: general – SubjectFull: PHYSIOLOGY Type: general Titles: – TitleFull: Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants - a Dutch prospective cohort study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: de Cock, Marijke – PersonEntity: Name: NameFull: de Boer, Michiel R. – PersonEntity: Name: NameFull: Lamoree, Marja – PersonEntity: Name: NameFull: Legler, Juliette – PersonEntity: Name: NameFull: van de Bor, Margot IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 12 Text: 2014 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 1476069X Numbering: – Type: volume Value: 13 – Type: issue Value: 1 Titles: – TitleFull: Environmental Health: A Global Access Science Source Type: main |
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