Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapy.

Authors: Geurts, Birgit S, Zeverijn, Laurien J, van Berge Henegouwen, Jade M, van der Wijngaart, Hanneke, Hoes, Louisa R, de Wit, Gijs F, Spiekman, Ilse AC, Battaglia, Thomas W, van Beek, Daphne M, Roepman, Paul, Jansen, Anne ML, de Leng, Wendy WJ, Broeks, Annegien, Labots, Mariette, van Herpen, Carla ML, Gelderblom, Hans, Verheul, Henk MW, Snaebjornsson, Petur, Voest, Emile E

Source: Journal of Pathology; Jul2024, Vol. 263 Issue 3, p288-299, 12p

Subject Terms: HEREDITARY nonpolyposis colorectal cancer, WHOLE genome sequencing, MICROSATELLITE repeats, IMMUNOTHERAPY, IMMUNE checkpoint proteins

Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics.

Authors: van der Wijngaart, Hanneke¹ (AUTHOR), Beekhof, Robin¹ (AUTHOR), Knol, Jaco C.¹ (AUTHOR), Henneman, Alex A.¹ (AUTHOR), de Goeij-de Haas, Richard¹ (AUTHOR), Piersma, Sander R.¹ (AUTHOR), Pham, Thang V.¹ (AUTHOR), Jimenez, Connie R.¹ (AUTHOR), Verheul, Henk M. W.² (AUTHOR), Labots, Mariette¹ (AUTHOR) m.labots@amsterdamumc.nl

Source: Clinical Proteomics. 11/8/2023, Vol. 20 Issue 1, p1-16. 16p.

Subject Terms: *RENAL cell carcinoma, *SUNITINIB, *THROMBIN receptors, *MASS spectrometry, *PROTEOMICS, *PROTEIN-tyrosine kinase inhibitors, *POST-translational modification

Limited clinical activity of palbociclib and ribociclib monotherapy in advanced cancers with cyclin D‐CDK4/6 pathway alterations in the Dutch DRUP and Australian MoST trials.

Authors: Zeverijn, Laurien J., Looze, Eleonora J., Thavaneswaran, Subotheni, van Berge Henegouwen, J. Maxime, Simes, Robert J., Hoes, Louisa R., Sjoquist, Katrin M., van der Wijngaart, Hanneke, Sebastian, Lucille, Geurts, Birgit S., Lee, Chee K., de Wit, Gijsbrecht F., Espinoza, David, Roepman, Paul, Lin, Frank P., Jansen, Anne M. L., de Leng, Wendy W. J., van der Noort, Vincent, Leek, Lindsay V. M., de Vos, Filip Y. F. L.

Source: International Journal of Cancer; Oct2023, Vol. 153 Issue 7, p1413-1422, 10p

Subject Terms: CYCLINS, CYCLIN-dependent kinase inhibitors, CANCER patients, PROGRESSION-free survival, CYCLIN-dependent kinases

Optimal treatment of opioid induced constipation in daily clinical practice – an observational study

Authors: Neefjes, Elisabeth C. W., van der Wijngaart, Hanneke, van der Vorst, Maurice J. D. L., ten Oever, Diederik, van der Vliet, Hans J., Beeker, Aart, Rhodius, Christiaan A., van den Berg, Hendrik P., Berkhof, Johannes, Verheul, Henk M. W.

Source: BMC palliative care. 18(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127237532.0x000001&indx=1&recIds=ETOCvdc_100127237532.0x000001

Advancing wide implementation of precision oncology: A liquid nitrogen‐free snap freezer preserves molecular profiles of biological samples.

Authors: van der Wijngaart, Hanneke¹ (AUTHOR), Jagga, Sahil² (AUTHOR), Dekker, Henk^1,3 (AUTHOR), de Goeij, Richard^1,3 (AUTHOR), Piersma, Sander R.^1,3 (AUTHOR), Pham, Thang V.^1,3 (AUTHOR), Knol, Jaco C.^1,3 (AUTHOR), Zonderhuis, Babs M.⁴ (AUTHOR), Holland, Harry J.² (AUTHOR), Jiménez, Connie R.^1,3 (AUTHOR), Verheul, Henk M. W.⁵ (AUTHOR), Vanapalli, Srinivas² (AUTHOR), Labots, Mariette^1,3 (AUTHOR) m.labots@amsterdamumc.nl

Source: Cancer Medicine. May2023, Vol. 12 Issue 9, p10979-10989. 11p.

Subject Terms: *MOLECULAR biology, *RNA sequencing, *LIVER biopsy, *ONCOLOGY, *COLD (Temperature)

Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours.

Authors: Geurts, Birgit S., Battaglia, Thomas W., van Berge Henegouwen, J. Maxime, Zeverijn, Laurien J., de Wit, Gijs F., Hoes, Louisa R., van der Wijngaart, Hanneke, van der Noort, Vincent, Roepman, Paul, de Leng, Wendy W. J., Jansen, Anne M. L., Opdam, Frans L., de Jonge, Maja J. A., Cirkel, Geert A., Labots, Mariette, Hoeben, Ann, Kerver, Emile D., Bins, Adriaan D., Erdkamp, Frans G.L., van Rooijen, Johan M.

Source: BMC Cancer; 3/4/2023, Vol. 23 Issue 1, p1-14, 14p

Subject Terms: MICROSATELLITE repeats, FRAMESHIFT mutation, PROGRESSION-free survival, BIOMARKERS, HEREDITARY nonpolyposis colorectal cancer, SURVIVAL rate

Prediction of response to sunitinib in patients with advanced renal cell carcinoma (RCC) using mass spectrometry-based (phospho) proteomics.

Authors: van der Wijngaart, Hanneke, Beekhof, Robin, Knol, Jaco C., Henneman, Alex A., de Goeij - de Haas, Richard, Piersma, Sander R., Pham, Thang V., Jimenez, Connie R., Verheul, Henk M.W., Labots, Mariette

Source: Journal of clinical oncology. 39(15 suppl):e16556-e16556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173203895.0x000001&indx=1&recIds=ETOCvdc_100173203895.0x000001

Efficacy and predictors of response of nivolumab in treatment-refractory MSI solid tumors: Results of a tumor-agnostic DRUP cohort.

Authors: Geurts, Birgit, Zeverijn, Laurien Joanna, Battaglia, Thomas W., van de Haar, Joris, van Berge Henegouwen, Jade M., Hoes, Louisa Rose, van der Wijngaart, Hanneke, Roepman, Paul, de Leng, Wendy W.J., Jansen, Anne M.L., van der Noort, Vincent, Chalabi, Myriam, Devriese, Lot A., Van Herpen, Carla M.L.-, Gelderblom, Hans, Verheul, Henk M.W., Voest, Emile E.

Source: Journal of Clinical Oncology; 2023 Supplement 16, Vol. 41, p2590-2590, 1p