An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns

Authors: Deal, Milena, Kar, Asha, Lee, Seung Hyuk T., Alvarez, Marcus, Rajkumar, Sandhya, Arasu, Uma Thanigai, Kaminska, Dorota, Männistö, Ville, Heinonen, Sini, van der Kolk, Birgitta W., Säiläkivi, Ulla, Saarinen, Tuure, Juuti, Anne, Pihlajamäki, Jussi, Kaikkonen, Minna U., Laakso, Markku, Pietiläinen, Kirsi H., Pajukanta, Päivi

Source: In The American Journal of Human Genetics 7 November 2024 111(11):2542-2560

Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism.

Authors: Muniandy, Maheswary, Joenväärä, Sakari, van der Kolk, Birgitta W., Tohmola, Tiialotta, Haltia, Hanna, Saari, Sina, Hakkarainen, Antti, Lundbom, Jesper, Kuula, Juho, Groop, Per-Henrik, Kaprio, Jaakko, Heinonen, Sini, Renkonen, Risto, Pietiläinen, Kirsi H.

Source: Biology Direct; 3/19/2025, Vol. 20 Issue 1, p1-15, 15p

Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

Authors: van der Kolk, Birgitta W., Saari, Sina, Lovric, Alen, Arif, Muhammad, Alvarez, Marcus, Ko, Arthur, Miao, Zong, Sahebekhtiari, Navid, Muniandy, Maheswary, Heinonen, Sini, Oghabian, Ali, Jokinen, Riikka, Jukarainen, Sakari, Hakkarainen, Antti, Lundbom, Jesper, Kuula, Juho, Groop, Per-Henrik, Tukiainen, Taru, Lundbom, Nina, Rissanen, Aila, Kaprio, Jaakko, Williams, Evan G., Zamboni, Nicola, Mardinoglu, Adil, Pajukanta, Päivi, Pietiläinen, Kirsi H.

Source: In Cell Reports Medicine 20 April 2021 2(4)

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery

Authors: van der Kolk, Birgitta W, Muniandy, Maheswary, Kaminska, Dorota, Alvarez, Marcus, Ko, Arthur, Miao, Zong, Valsesia, Armand, Langin, Dominique, Vaittinen, Maija, Pääkkönen, Mirva, Jokinen, Riikka, Kaye, Sanna, Heinonen, Sini, Virtanen, Kirsi A, Andersson, Daniel P, Männistö, Ville, Saris, Wim H, Astrup, Arne, Rydén, Mikael, Blaak, Ellen E, Pajukanta, Päivi, Pihlajamäki, Jussi, Pietiläinen, Kirsi H

Source: Journal of clinical endocrinology & metabolism. 106(5):1312-1324

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133336042.0x000001&indx=1&recIds=ETOCvdc_100133336042.0x000001

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

Authors: van der Kolk, Birgitta W., Goossens, Gijs H., Jocken, Johan W., Kersten, Sander, Blaak, Ellen E.

Source: Journal of clinical endocrinology and metabolism. 101(6):2332-2339

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606507675&indx=1&recIds=ETOCRN606507675

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits.

Authors: Brotman, Sarah M., Oravilahti, Anniina, Rosen, Jonathan D., Alvarez, Marcus, Heinonen, Sini, van der Kolk, Birgitta W., Fernandes Silva, Lilian, Perrin, Hannah J., Vadlamudi, Swarooparani, Pylant, Cortney, Deochand, Sonia, Basta, Patricia V., Valone, Jordan M., Narain, Morgan N., Stringham, Heather M., Boehnke, Michael, Kuusisto, Johanna, Love, Michael I., Pietiläinen, Kirsi H., Pajukanta, Päivi

Source: Diabetes; Nov2023, Vol. 72 Issue 11, p1707-1718, 12p

Subject Terms: GENE expression, LOCUS (Genetics), GENOME-wide association studies, RNA sequencing, ADIPOSE tissues, ADIPOSE tissue diseases

Baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss in individuals with obesity.

Authors: Oghabian, Ali, van der Kolk, Birgitta W., Marttinen, Pekka, Valsesia, Armand, Langin, Dominique, Saris, W. H., Astrup, Arne, Blaak, Ellen E., Pietiläinen, Kirsi H.

Source: PeerJ; Mar2023, p1-19, 19p

Subject Terms: WEIGHT loss, ADIPOSE tissues, GENE expression, SUPERVISED learning, SUPPORT vector machines, HIGH-fat diet, OBESITY

Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study

Authors: Vogelzangs, Nicole, van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., van der Kolk, Birgitta W., Jocken, Johan W. E., Goossens, Gijs H., Schaper, Nicolaas C., Henry, Ronald M. A., Eussen, Simone J. P. M., Valsesia, Armand, Hankemeier, Thomas, Astrup, Arne, Saris, Wim H. M., Stehouwer, Coen D. A., Blaak, Ellen E., Arts, Ilja C. W.

Source: International Journal of Obesity (formerly International Journal of Obesity and Related Metabolic Disorders); June 2020, Vol. 44 Issue: 6 p1376-1386, 11p

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans.

Authors: van der Kolk, Birgitta W.¹, Kalafati, Marianthi^2,3, Adriaens, Michiel³, Greevenbroek, Marleen M. J. van⁴, Vogelzangs, Nicole^3,5, Saris, Wim H. M.¹, Astrup, Arne⁶, Valsesia, Armand⁷, Langin, Dominique^8,9,10, van der Kallen, Carla J. H.⁴, Eussen, Simone J. P. M.⁵, Schalkwijk, Casper G.⁴, Stehouwer, Coen D. A.⁴, Goossens, Gijs H.¹, Arts, Ilja C. W.^3,5, Jocken, Johan W. E.¹, Evelo, Chris T.^2,3, Blaak, Ellen E.¹ e.blaak@maastrichtuniversity.nl, van Greevenbroek, Marleen M J⁴ (AUTHOR)

Source: Diabetes. Dec2019, Vol. 68 Issue 12, p2247-2258. 12p. 2 Color Photographs, 3 Charts.

Subject Terms: *INSULIN resistance, *ADIPOSE tissues, *ABDOMINAL adipose tissue, *ETIOLOGY of diseases, *GLUCOSE tolerance tests

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